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Single and Combined Exposure to Zinc- and Copper-Containing Welding Fumes Lead to Asymptomatic Systemic Inflammation
Objective: Recently, it has been shown that exposure to welding fumes containing both zinc and copper leads to asymptomatic systemic inflammation in humans as shown by an increase of blood C-reactive protein. In the present study, it was investigated which metal is responsible for this effect. Methods: Fifteen healthy male subjects were exposed under controlled conditions to welding fumes containing either zinc, or copper, or copper and zinc. Results: For each exposure blood C-reactive protein increased. Conclusions: Copper- and zinc-containing welding fumes are able to induce systemic inflammation...
Engineered Nanomaterials
An update on the Toxicology and Work Health Hazards This publication provides updated information about the toxicology and work health hazards of engineered nanomaterials. Safe Work Australia commissioned ToxConsult Pty Ltd to undertake this project. This report updates and builds on the findings of the 2009 report Engineered nanomaterials – a review of the toxicology and health hazards and provides specific information about the health hazards of: •Carbon nanotubes •Titanium dioxide •Zinc oxide •Cerium oxide, and •Silver The report provides suggestions for workplace...
Biological Effects of Emissions From Resistance Spot Welding of Zinc-Coated Material After Controlled Exposure of Healthy Human Subjects
Objective: Do emissions from a resistance spot welding process of zinc-coated materials induce systemic inflammation in healthy subjects after exposure for 6 hours? Methods: Twelve healthy male subjects were exposed once for 6 hours either to filtered ambient air or to welding fume from resistance spot welding of zinc-coated material (mass concentration approximately 100 μg m−3). Biological effects were measured before, after, and 24 hours after exposure. Results: At the concentrations used in this study, however, the suspected properties of ultrafine particles did not lead to systemic...
Relationship Between Welding Fume Concentration and Systemic Inflammation After Controlled Exposure of Human Subjects With Welding Fumes From Metal Inert Gas Brazing of Zinc-Coated Materials
Objectives: It has been shown that exposure of subjects to emissions from a metal inert gas (MIG) brazing process of zinc-coated material led to an increase of high-sensitivity C-reactive protein (hsCRP) in the blood. In this study, the no-observed-effect level (NOEL) for such emissions was assessed. Methods: Twelve healthy subjects were exposed for 6 hours to different concentrations of MIG brazing fumes under controlled conditions. High-sensitivity C-reactive protein was measured in the blood. Results: For welding fumes containing 1.20 and 1.50 mg m−3 zinc, high-sensitivity C-reactive protein...

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