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IARC evaluation of five organophosphate pesticides
A Working Group of 17 experts from 11 countries met at the International Agency for Research on Cancer (IARC), the specialized cancer agency of the World Health Organization on 3-10 March 2015 to review the available published scientific evidence and evaluate the carcinogenicity of five organophosphate insecticides and herbicides: diazinon, glyphosate, malathion, parathion, and tetrachlorvinphos. A summary of the final evaluations together with a short rationale have now been published online in The Lancet Oncology , and the detailed assessments will be published as Volume 112 of the IARC Monographs...
Bruit et substances ototoxiques : cocktail à risque pour l’audition
De nombreuses études ont mis en évidence un risque accru de troubles auditifs du fait de phénomènes de synergies entre certains agents chimiques et le bruit. Quelles sont les substances concernées ? Comment fonctionnent ces co-expositions? Quels sont les effets sur l'homme ? Cet article apporte un éclairage sur ces questions. Source: http://www.hst.fr/inrs-pub/inrs01.nsf/IntranetObject-accesParReference/HST_DC%208/$File/DC8.pdf
Australian Work Exposures Study (AWES) - Polycyclic aromatic hydrocarbons (PAHs)
The Australian Work Health and Safety Strategy 2012-2022 (the Strategy) describes work-related cancer as a priority disorder and understanding current hazardous exposures and the effectiveness of controls as a research priority. The Australian Work Exposures Study (AWES) was a national survey that investigated work-related exposures among Australian workers to 38 agents classified by the International Agency for Research on Cancer (IARC) as known or suspected carcinogens. Some polycyclic aromatic hydrocarbons (PAHs) are classified as a known or suspected human carcinogens by the IARC and the work...
Australian Work Exposures Study (AWES) - Formaldehyde
The Australian Work Health and Safety Strategy 2012-2022 (the Strategy) describes work-related cancer as a priority disorder and understanding current hazardous exposures and the effectiveness of controls as a research priority. The Australian Work Exposures Study (AWES) was a national survey that investigated work-related exposures among Australian workers to 38 agents classified by the International Agency for Research on Cancer (IARC) as known or suspected carcinogens. Formaldehyde is classified as a known human carcinogen by the IARC and the work described in this report uses AWES data to:...
Australian Work Exposures Study (AWES) - Lead and lead compounds
The Australian Work Health and Safety Strategy 2012-2022 (the Strategy) describes work-related cancer as a priority disorder and understanding current hazardous exposures and the effectiveness of controls as a research priority. The Australian Work Exposures Study (AWES) was a national survey that investigated work-related exposures among Australian workers to 38 agents classified by the International Agency for Research on Cancer (IARC) as known or suspected carcinogens. Some forms of lead are considered to be probable carcinogens and the work described in this report uses AWES data to: •...
List of MAK and BAT Values 2014
Maximum Concentrations and Biological Tolerance Values at the Workplace MAK values (Maximum Concentrations at the Workplace) and BAT values (Biological Tolerance Values) promote the protection of health at the workplace. They are an efficient indicator for the toxic potential of chemical compounds. This book contains a list of scientifically recommended threshold limit values for more than 1000 chemical compounds. Carcinogens, germ cell mutagens, embryotoxicants, sensitizing substances and those potentially bearing a risk to pregnancy are treated separately. Of particular value are the lists of...
Exposition aux mélanges de substances chimiques
Quels défis pour la recherche et l'évaluation des risques ? L'agence sanitaire française -Anses- et les instituts allemand -BfR- et danois -DTU- ont organisé conjointement, les 10 et 11 décembre 2013, une conférence internationale sur les effets de l'exposition aux mélanges de substances chimiques et l'évaluation des risques, une préoccupation majeure pour de nombreux pays dans le monde et un véritable défi scientifique à relever. L'objectif de ces deux jours était de promouvoir les échanges...
Une étude de l’IRSST sur les risques liés au mélange de plusieurs substances chimiques
Lors de déversements accidentels de substances chimiques dans l'environnement, que ce soit dans le cas d'incidents routiers ou ferroviaires (transport de matières dangereuses), ou encore d'accidents industriels, des travailleurs, des secouristes, des pompiers et même la population générale peuvent être exposés simultanément, sur de courtes périodes, à d'importantes concentrations de plusieurs substances chimiques. Dans de telles situations, une exposition simultanée à plusieurs substances peut induire...
Occupational Exposure to Carbon Nanotubes and Nanofibers : Current Intelligence Bulletin 65
This NIOSH Current Intelligence Bulletin (1) reviews the animal and other toxicological data relevant to assessing the potential non-malignant adverse respiratory effects of CNT and CNF, (2) provides a quantitative risk assessment based on animal dose-response data, (3) proposes a recommended exposure limit (REL) of 1 μg/m3 elemental carbon as a respirable mass 8-hour time-weighted average (TWA) concentration, and (4) describes strategies for controlling workplace exposures and implementing a medical surveillance program. The NIOSH REL is expected to reduce the risk for pulmonary inflammation...
New HSE guidance on Nanotechnology and updated website
HSE has produced new guidance aimed at employers, health and safety managers and SMEs who use or manufacture nanomaterials. The guidance is based on the generic principles of COSHH and good control practice and includes information on a range of nanomaterials. The nanotechnology website has also been updated and now includes information on the toxicological properties of nanomaterials. Source : http://www.hse.gov.uk/nanotechnology/index.htm?eban=rss -
Chemical Exposure among Professional Ski Waxers — Characterization of Individual Work Operations
Background : Preparation of skis prior to skiing competitions involves several individual work operations and the use of a wide variety of chemically based ski waxing products to improve the performance of the skis, including products used after skiing for wax removal and ski sole cleaning. Modern ski waxes consist mainly of petroleum-derived straight-chain aliphatic hydrocarbons, perfluoro-n-alkanes or polyfluorinated n-alkanes. The wax cleaning products contain solvents such as neat aliphatic hydrocarbons (aliphates) or a mixture with limonene. Different ski waxing work operations can result...
Fatalities due to dichloromethane in paint strippers: A continuing problem
Background Exposure to dichloromethane (DCM or methylene chloride - CH2Cl2) in paint strippers continues to be an avoidable source of morbidity and mortality. DCM has been under regulatory scrutiny by occupational and consumer product agencies since the identification of its carcinogenicity in the mid-1980s. Methods We investigated two independent workplace incidents that resulted in three cases of DCM intoxication from paint stripper use. Results Each incident investigated resulted in a fatality. A third worker suffered obtundation requiring hospitalization and intubation. Conclusions The continued...
Two reproduction toxicity evaluations – Chloramphenicol and indium and its compounds
The Health Council of the Netherlands has reviewed chloramphenicol and indium compounds. Indium is used in bearings for cars and aircrafts, in solders and low-melting alloys, and in nuclear reactor control rods. Indium and its compounds, including indium antimonide (InSb), indium arsenide (InAs), and indium phosphide (InP), find application in semiconductor devices, transistors, and transistor materials. Indium oxide is used for colouring glass. Indium sulphate is used in electroplating, and radioisotopes of indium and indium compounds (including indium trichloride) are employed in the treatment...
Filling the Knowledge Gaps for Safe Nanotechnology in the Workplace
A Progress Report from the NIOSH Nanotechnology Research Center, 2004–2011. This 2012 update presents the program accomplishments of the NTRC from its inception in 2004 through 2011. It includes an analysis of the progress made toward accomplishing the goals and objectives of the NIOSH Strategic Plan for Nanotechnology Research and toward addressing the goals and research needs identified in the U.S. National Nanotechnology Initiative (NNI) Environmental, Health, and Safety (EHS) research strategy. Source : http://osha.europa.eu/en/news/int-filling-the-knowledge-gaps-for-safe-nanotechnology...
Valeur toxicologique de référence pour le chlorure de vinyle : Avis de l’Anses Rapport d’expertise collective
Dans le cadre du programme de travail de l'Anses sur les VTRs cancérogènes, une phase pilote a été organisée afin de s'assurer de la mise en pratique de la méthode de construction proposée. Des profils toxicologiques et des VTRs ont été construits sous formes de prestation pour le benzène, le cadmium, l'éthanol, le naphtalène et le chlorure de vinyle. Source : http://www.anses.fr/Documents/CHIM2009sa0348Ra.pdf
Neurotoxic exposures and effects: Gender and sex matter! Hänninen Lecture 2011
Donna Mergler, cofondatrice du CINBIOSE, a écrit un article portant sur l'importance du genre et du sexe dans les recherches en neurotoxicologie de l'environnement et du travail. Trop peu de recherches en tiennent compte et ne différencient pas clairement le genre et le sexe. C'est pourquoi l'auteure souligne que c'est un impératif d'en tenir compte! Source : Mergler, D. Neurotoxic exposures and effects: Gender and sex matter! Ha¨nninen Lecture 2011. Neurotoxicology. 2012. http://www.cinbiose.uqam.ca/upload/files/Mergler_2012_Neurotox_gender__sex...
Effects of Chemical Co-exposures at Doses Relevant for Human Safety Assessments
Chemical regulation is mainly based on single substances, but exposure is to complex mixtures, which raises the question of whether the regulatory framework is adequate and protective. There has long been an interest in the toxicology of mixtures, but most studies have been conducted at effect levels for the components of a mixture. This review focused specifically on studies where a mixture has been tested at doses which are at or below the NO(A)EL for every component of the mixture. This is the only dose region in which mixture toxicity could threaten regulatory safety margins. A thorough literature...
Risks and Control of Nanomaterials
Editorial / Trevor Ogden. In this issue we bring together 12 articles on nanomaterials and approaches to risk control. The issue originated with the conference held in April (2011) by the Institut National de Recherche et de Sécurité (INRS) in Nancy, France, on risks associated with nanoparticles and nanomaterials. Topics included measurement and control process design, occupational toxicology, protection, epidemiology, assessment and management of risk of nanoparticles. Source : http://annhyg.oxfordjournals.org/content/56/5/489.full
New ISO Technical Report Guides Characterization of Nanomaterials in Toxicology
The International Organization for Standardization (ISO) recently published a Technical Report (TR) that provides guidance on the physicochemical characterization of manufactured nano-objects prior to toxicological assessment. ISO TR 13014:2012 , Nanotechnologies - Guidance on physicochemical characterization of engineered nanoscale materials for toxicologic assessment, is intended to assist health scientists and experts to understand, plan, identify, and address relevant physicochemical characteristics of nano-objects before conducting toxicological tests on them. Source : http://www.ansi.org...
A Systematic Review of Aluminium Phosphide Poisoning
Every year, about 300,000 people die because of pesticide poisoning worldwide. The most common pesticide agents are organophosphates and phosphides, aluminium phosphide (AlP) in particular. AlP is known as a suicide poison that can easily be bought and has no effective antidote. Its toxicity results from the release of phosphine gas as the tablet gets into contact with moisture. Phosphine gas primarily affects the heart, lungs, gastrointestinal tract, and kidneys. Poisoning signs and symptoms include nausea, vomiting, restlessness, abdominal pain, palpitation, refractory shock, cardiac arrhythmias...
EPA releases formerly confidential chemical information
The U.S. Environmental Protection Agency (EPA) is making available hundreds of studies on chemicals that were previously treated as confidential business information (CBI). EPA Administrator Lisa P. Jackson said the move will increase transparency and enhance the agency's chemicals management program. Newly available information can be found using EPA's Chemical Data Access Tool. Since 2009, 577 formerly confidential chemical identities are no longer confidential and more than 1,000 health and safety studies are now accessible to the public that were previously unavailable or only available...
Health assessment for trichloroethylene
Ce document de l’Environmental Protection Agency (EPA) des États-Unis annonce l'achèvement de l'évaluation d’impact sur la santé du polluant chimique trichloréthylène (TCE) et l’incorporation de l'évaluation dans l'Integrated Risk Information System (IRIS). La base de données IRIS fournit de l'information scientifique pour les décideurs de tous les niveaux. Le trichloréthylène est un solvant chloré largement utilisé et maintenant officiellement classé comme un...
Introducing the SINLIST
ChemSec, The International Chemical Secretariat, is a non-profit organisation dedicated to working towards a toxic free environment. Based in Göteborg, Sweden, ChemSec was founded in 2002 by four Swedish environmental organisations: Swedish Society for Nature Conservation, WWF Sweden, Nature and Youth and Friends of the Earth Sweden. These NGOs are the ChemSec member organisations and are represented on the ChemSec board. ChemSec operates through support from a broad spectrum of society. A main contributor is the Swedish Government, but ChemSec also receives financial support from charitable...
eChemPortal: Global Portal to Information on Chemical Substances
Users of eChemPortal are now able to search specific endpoint properties for substances contained in The Ecological Categorization Results from Canada Database. This Database contains the ecological categorization results for substances on the Canadian Domestic substance list and the supporting data on: Inherent toxicity, Persistency and Bioaccumulation. Source : http://www.oecd.org/document/9/0,3343,en_2649_34379_35211849_1_1_1_1,00.html
Acute Illnesses Associated With Insecticides Used to Control Bed Bugs
The common bed bug, Cimex lectularius, is a wingless, reddish-brown insect that requires blood meals from humans, other mammals, or birds to survive (1). Bed bugs are not considered to be disease vectors (2,3), but they can reduce quality of life by causing anxiety, discomfort, and sleeplessness (4). Bed bug populations and infestations are increasing in the United States and internationally (3,5). Bed bug infestations often are treated with insecticides, but insecticide resistance is a problem, and excessive use of insecticides or use of insecticides contrary to label directions can raise the...
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