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Current state of knowledge on the health effects of engineered nanomaterials in workers
A systematic review of human studies and epidemiological investigations Objectives: The widespread application of nano-enabled products and the increasing likelihood for workplace exposures make understanding engineered nanomaterial (ENM) effects in exposed workers a public and occupational health priority. The aim of this study was to report on the current state of knowledge on possible adverse effects induced by ENM in humans to determine the toxicological profile of each type of ENM and potential biomarkers for early detection of such effects in workers. Methods: A systematic review of human...
Dioxyde de titane sous forme nanoparticulaire : l’Anses définit une Valeur Toxicologique de Référence (VTR) pour l’exposition chronique par inhalation
Le dioxyde de titane sous forme nanoparticulaire est utilisé dans de nombreuses applications industrielles et commerciales. Dans le cadre de sa mission nationale d'élaboration de valeurs sanitaires de référence, l'Anses a été chargée de définir une Valeur Toxicologique de Référence (VTR) pour le dioxyde de titane sous forme nanoparticulaire (TiO 2 -NP). Suite à une analyse approfondie de l'ensemble des données de toxicité disponibles, l'Agence recommande une VTR chronique par inhalation pour...
Agents fibrogènes et cancérogènes dans les mines d’or et de fer du Québec - Étude exploratoire
De récentes études ont mis en évidence que les travailleurs des mines d’or du Dakota et des mines de fer du Minnesota sont exposés à des particules minérales allongées (PMA). En particulier, les mineurs du Minnesota présentent un risque plus élevé de décès par cancer du poumon, par mésothéliome et par maladies cardiaques que la population générale. Comme l’intérêt renouvelé pour l’exploration de nouveaux gisements d’or et de fer dans le Nord...
Comparison of Inhalation and Intratracheal Instillation as Testing Methods for Characterisation of Granular Biopersistent Particles (GBP)
Comparison of bronchoalveolar lavage fluid (BALF) data The comparison of the inflammatory potency of the 6 GBP candidates came out with a good accordance of the polymorphonuclear neutrophil (PMN) levels in the differential cell count for µ-TiO2. On day 3 post-treatment, PMN were not increased statistically significantly in the low and high dose groups, neither after instillation nor after inhalation. Thus, a very low inflammogenicity confirmed µ-TiO2 as GBP. µ-BaSO4 (low dose groups) showed a behaviour similar to µ-TiO2. However, for nano-TiO2 P25 an evident difference was...
Literature study on the uses and risks of nanomaterials as pigments in the European Union
This report provides a review on the safe use of nano-sized pigments when used by professionals, workers or consumers. Extensive literature searches were carried out in combination with analyses of data from national nano-inventories to capture the current state of play. The report provides a list of nano-sized pigments currently identified on the EU market and discusses potential risks arising from their use in paints, coatings, printer toner cartridges, personal care products, tattooes as well as other potential uses of nanopigments. Data for hazard and risk assessment are not available for the...
Welding, Molybdenum Trioxide, and Indium Tin Oxide
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 118 This volume of the IARC Monographs provides evaluations of the carcinogenicity of welding and welding fumes, molybdenum trioxide, and indium tin oxide. Worldwide, an estimated 11 million workers have a job title of welder, and around 110 million additional workers probably incur welding-related exposures. Welding can involve exposures to fumes, gases, ultraviolet radiation and electromagnetic fields, and co-exposures to asbestos and solvents. The extent and type of exposure can depend on the process used, the material...
Soignants et médicaments cytotoxiques
Place de la biométrologie dans la maîtrise des risques dans le temps Les médicaments cytotoxiques utilisés dans les traitements des cancers présentent une toxicité intrinsèque, du fait de leurs propriétés génotoxiques, tératogènes et cancérigènes. Les professionnels de santé pouvant y être exposés, il est essentiel de garantir leur sécurité et de mettre en place des programmes d'évaluation des expositions pour documenter les expositions, juger de l'efficacité...
L’Anses met à disposition une base de données sur plus de 500 valeurs toxicologiques de référence
L'Agence poursuit depuis 2004 la réalisation d'un programme national sur les valeurs toxicologiques de référence (VTR). Les VTR sont des indicateurs biologiques qui permettent de qualifier ou quantifier sur une base scientifique un risque pour la santé humaine lié à l'exposition à une substance chimique. Elles sont utiles pour les différents acteurs de la gouvernance des risques : entreprises, expertise publique et autorités chargées de la gestion du risque. L'Anses publie une base de données regroupant...
Activation des éosinophiles humains par des nanoparticules
L'économie du Canada, comme celle de bien d'autres pays industrialisés, bénéficie du développement des nanotechnologies dont le fort potentiel peut être exploité dans plusieurs secteurs industriels. Un nombre croissant d'entreprises québécoises de production de nanoparticules (NP) est d'ailleurs déjà implanté et tout porte à croire que d'autres emboîteront le pas dans les années à venir. Ce faisant, non seulement le nombre de travailleurs œuvrant dans la fabrication...
IARC Monographs Volume 112: Some Organophosphate Insecticides and Herbicides
This volume of the IARC Monographs provides evaluations of the carcinogenicity of some organophosphate insecticides and herbicides, including diazinon, glyphosate, malathion, parathion, and tetrachlorvinphos. Diazinon acts on a wide range of insects on crops, gardens, livestock, and pets, but most uses have been restricted in the USA, Canada, and the European Union since the 1980s. Glyphosate is the most heavily used agricultural and residential herbicide in the world, and has been detected in soil, air, surface water, and groundwater, as well as in food. Malathion is one of the oldest and most...
Challenges on the toxicological predictions of engineered nanoparticles
The perceived enormous potential of nanotechnology in contributing to sustainable innovation has led to the growth of investments into new industrial applications and consumer products. However, the lack of tools that are needed to generate early knowledge about the potential adverse effects, combined with the uncertainties regarding the health and safety risks of engineered nanoparticles (ENPs), are a potential threat to the acceptability by society of the nanotechnology innovations, due to the rising societal concerns that are based on generic worries. In order to tackle these issues, it has...
Summary of evidence – Solvent-based hydrophobic coatings and risks for acute respiratory toxicity
Water repellent coatings are increasingly used by different industries to reduce water and dirt sticking to surfaces. The coatings can be applied by processes that minimise the risk that operators inhale the product but there is evidence that some products are applied by spraying, creating an inhalable mist. This review examined evidence about these coatings and whether lung disease occurs when applied by spraying. Scientific studies on the hazardous properties of these products, and clinical studies reporting lung disease in people using them, were considered. A consistent finding was that some...
IARC Monographs Volume 111: Some Nanomaterials and Some Fibres
This volume of the IARC Monographs contains evaluations of the carcinogenic hazard to humans of fluoro-edenite fibrous amphibole, silicon carbide fibres and whiskers, and carbon nanotubes. None of these agents had been evaluated previously by the Working Group. Source: http://monographs.iarc.fr/ENG/Monographs/vol111/index.php
Chromosomal aberrations, sister chromatid exchanges, and micronuclei in lymphocytes of oncology department personnel handling anti-neoplastic drugs
Objective: Concern exists regarding the possible hazards to the personnel handling anti-neoplastic drugs. The purpose of the present study was to assess the genotoxicity induced by anti-neoplastic agents in oncology department personnel. Materials and methods: To do this, the frequency of chromosomal aberrations (CAs) induced in peripheral blood lymphocytes was assessed at G0 phase of the cell cycle using metaphase analysis, cytokinesis block-micronucleus (MN) assay and sister chromatid exchange (SCE) assay. These cytogenetic end points were measured among 71 nurses in oncology department and 10...
History of knowledge and evolution of occupational health and regulatory aspects of asbestos exposure science: 1900–1975
The understanding by industrial hygienists of the hazards of asbestos and appropriate ways to characterize and control exposure has evolved over the years. Here, a detailed analysis of the evolution of industrial hygiene practices regarding asbestos and its health risks, from the early 1900s until the advent of the national occupational health and safety regulatory structure currently in place in the US (early-to-mid 1970s) is presented. While industrial hygienists recognized in the early 1900s that chronic and high-level exposures to airborne concentrations of asbestos could pose a serious health...
Occupational Exposure to Diacetyl and 2,3-Pentanedione
Diacetyl and its substitute, 2,3-pentanedione, are widely used as flavoring compounds. The National Institute for Occupational Safety and Health (NIOSH) objective in establishing recommended exposure limits (RELs) for diacetyl and 2,3-pentanedione is to reduce the risk of respiratory impairment (decreased lung function) and the severe irreversible lung disease obliterative bronchiolitis associated with occupational exposure. In this Criteria Document, NIOSH reviews the scientific literature concerning potential health effects, toxicology, and risk assessment pertaining to diacetyl and 2,3-pentanedione...
Prévenir les risques chimiques lors d'une chimiothérapie intrapéritonéale pressurisée par aérosolisation (CIPPA ou PIPAC)
Une équipe de la faculté de médecine de l'Université de la Ruhr, à Bochum en Allemagne, a récemment mis au point une nouvelle technique de chimiothérapie intrapéritonéale : la chimiothérapie intrapéritonéale pressurisée par aérosolisation (CIPPA, PIPAC en anglais). Cette procédure, apparentée à la chimiothérapie hyperthermique intrapéritonéale (CHIP) utilisée depuis plusieurs années, offre de nouvelles perspectives pour la prise en charge...
Taking stock of the occupational safety and health challenges of nanotechnology: 2000–2015
Engineered nanomaterials significantly entered commerce at the beginning of the 21st century. Concerns about serious potential health effects of nanomaterials were widespread. Now, approximately 15 years later, it is worthwhile to take stock of research and efforts to protect nanomaterial workers from potential risks of adverse health effects. This article provides and examines timelines for major functional areas (toxicology, metrology, exposure assessment, engineering controls and personal protective equipment, risk assessment, risk management, medical surveillance, and epidemiology) to identify...
Manipulation des anticorps monoclonaux (Acm) en milieu de soins
Pratiques et mesures de prévention L'essor des anticorps monoclonaux (Acm) pose la question de la prévention à mettre en place pour le personnel qui les manipule. Un état des lieux des pratiques et des mesures de prévention est réalisé en milieu de soins pour dégager des pistes d'amélioration. Les données retrouvées dans la littérature sont limitées et la toxicité professionnelle des Acm mal connue. Une enquête est menée auprès du personnel manipulant des Acm et auprès...
Australian Work Exposure Study (AWES) - Carcinogen Exposures Construction Industry
A random, population-based sample of 5528 Australian workers participated in the Australian Work Exposure Study (AWES). Workers answered questions about the tasks they completed and the controls used at work. Based on their responses to those questions, the likelihood of exposure to 38 known or suspected carcinogens was estimated. The AWES focused on the most common tasks performed at work. Workers were not asked directly about their exposures to carcinogens and exposure levels were not measured in the workplace. This report describes the responses provided by 459 AWES participants categorised...
Australian Work Exposures Study (AWES) - Carcinogen Exposures Manufacturing Industry
A random, population-based sample of 5528 Australian workers participated in the Australian Work Exposure Study (AWES). Workers answered questions about the tasks they completed and the controls used at work. Based on their responses to those questions, the likelihood of exposure to 38 known or suspected carcinogens was estimated. The AWES focused on the most common tasks performed at work. Workers were not asked directly about their exposures to carcinogens and exposure levels were not measured in the workplace. This report describes the responses provided by 281 AWES participants categorised...
Ecotoxicologie des nanomatériaux
Nouvelles approches analytiques Quatre ans après la publication de la note ayant pour titre « Écotoxicologie des nanoparticules : avancées méthodologiques dans l'évaluation des risques» (1), cette note a pour objectif de refaire le bilan sur les progrès réalisés dans le domaine. En effet, la période de veille écoulée a été marquée par la publication de nombreuses revues de la littérature contenant notamment le mot-clef « analytical » : concept analytique, approche...
Reproductive and developmental toxicity of carbon-based nanomaterials
A literature review We summarized the findings of reproductive and developmental toxicity studies on carbon-based nanomaterials (CNMs). Placental transfer of fullerenes in rats and single-walled (SW) and multi-walled (MW) CNTs in mice was shown after intravenous injection. SWCNTs appeared to be embryolethal and teratogenic in mice when given by intravenous injection and induced death and growth retardation in chicken embryos. In mice-administered MWCNTs, fetal malformations after intravenous and intraperitoneal injections and intratracheal instillation, fetal loss after intravenous injection, behavioral...
Neurotoxicity associated with exposure to 1-bromopropane in golf-club cleansing workers
BACKGROUND: 1-Bromopropane (1-BP) is an alternative to ozone-depleting solvent that is used in degreasing, dry cleaning, spray adhesives, and aerosol solvents. Occupational exposure to 1-BP is associated with adverse peripheral sensory, motor, and central nervous system (CNS) effects. We report our Health Hazard and Medical Evaluation of 6 patients with neurotoxicity associated with occupational exposure to 1-BP. Case series and environmental evaluation. Six workers, 1 male and 5 female, were exposed to high ambient 1-BP concentrations while employed in a golf club cleaning factory. 1-BP was identified...
IARC evaluation of five organophosphate pesticides
A Working Group of 17 experts from 11 countries met at the International Agency for Research on Cancer (IARC), the specialized cancer agency of the World Health Organization on 3-10 March 2015 to review the available published scientific evidence and evaluate the carcinogenicity of five organophosphate insecticides and herbicides: diazinon, glyphosate, malathion, parathion, and tetrachlorvinphos. A summary of the final evaluations together with a short rationale have now been published online in The Lancet Oncology , and the detailed assessments will be published as Volume 112 of the IARC Monographs...
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