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Current state of knowledge on the health effects of engineered nanomaterials in workers
A systematic review of human studies and epidemiological investigations Objectives: The widespread application of nano-enabled products and the increasing likelihood for workplace exposures make understanding engineered nanomaterial (ENM) effects in exposed workers a public and occupational health priority. The aim of this study was to report on the current state of knowledge on possible adverse effects induced by ENM in humans to determine the toxicological profile of each type of ENM and potential biomarkers for early detection of such effects in workers. Methods: A systematic review of human...
History of knowledge and evolution of occupational health and regulatory aspects of asbestos exposure science: 1900–1975
The understanding by industrial hygienists of the hazards of asbestos and appropriate ways to characterize and control exposure has evolved over the years. Here, a detailed analysis of the evolution of industrial hygiene practices regarding asbestos and its health risks, from the early 1900s until the advent of the national occupational health and safety regulatory structure currently in place in the US (early-to-mid 1970s) is presented. While industrial hygienists recognized in the early 1900s that chronic and high-level exposures to airborne concentrations of asbestos could pose a serious health...
Effects of Chemical Co-exposures at Doses Relevant for Human Safety Assessments
Chemical regulation is mainly based on single substances, but exposure is to complex mixtures, which raises the question of whether the regulatory framework is adequate and protective. There has long been an interest in the toxicology of mixtures, but most studies have been conducted at effect levels for the components of a mixture. This review focused specifically on studies where a mixture has been tested at doses which are at or below the NO(A)EL for every component of the mixture. This is the only dose region in which mixture toxicity could threaten regulatory safety margins. A thorough literature...

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