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Current state of knowledge on the health effects of engineered nanomaterials in workers
A systematic review of human studies and epidemiological investigations Objectives: The widespread application of nano-enabled products and the increasing likelihood for workplace exposures make understanding engineered nanomaterial (ENM) effects in exposed workers a public and occupational health priority. The aim of this study was to report on the current state of knowledge on possible adverse effects induced by ENM in humans to determine the toxicological profile of each type of ENM and potential biomarkers for early detection of such effects in workers. Methods: A systematic review of human...
Literature study on the uses and risks of nanomaterials as pigments in the European Union
This report provides a review on the safe use of nano-sized pigments when used by professionals, workers or consumers. Extensive literature searches were carried out in combination with analyses of data from national nano-inventories to capture the current state of play. The report provides a list of nano-sized pigments currently identified on the EU market and discusses potential risks arising from their use in paints, coatings, printer toner cartridges, personal care products, tattooes as well as other potential uses of nanopigments. Data for hazard and risk assessment are not available for the...
Activation des éosinophiles humains par des nanoparticules
L'économie du Canada, comme celle de bien d'autres pays industrialisés, bénéficie du développement des nanotechnologies dont le fort potentiel peut être exploité dans plusieurs secteurs industriels. Un nombre croissant d'entreprises québécoises de production de nanoparticules (NP) est d'ailleurs déjà implanté et tout porte à croire que d'autres emboîteront le pas dans les années à venir. Ce faisant, non seulement le nombre de travailleurs œuvrant dans la fabrication...
Challenges on the toxicological predictions of engineered nanoparticles
The perceived enormous potential of nanotechnology in contributing to sustainable innovation has led to the growth of investments into new industrial applications and consumer products. However, the lack of tools that are needed to generate early knowledge about the potential adverse effects, combined with the uncertainties regarding the health and safety risks of engineered nanoparticles (ENPs), are a potential threat to the acceptability by society of the nanotechnology innovations, due to the rising societal concerns that are based on generic worries. In order to tackle these issues, it has...
IARC Monographs Volume 111: Some Nanomaterials and Some Fibres
This volume of the IARC Monographs contains evaluations of the carcinogenic hazard to humans of fluoro-edenite fibrous amphibole, silicon carbide fibres and whiskers, and carbon nanotubes. None of these agents had been evaluated previously by the Working Group. Source: http://monographs.iarc.fr/ENG/Monographs/vol111/index.php
Taking stock of the occupational safety and health challenges of nanotechnology: 2000–2015
Engineered nanomaterials significantly entered commerce at the beginning of the 21st century. Concerns about serious potential health effects of nanomaterials were widespread. Now, approximately 15 years later, it is worthwhile to take stock of research and efforts to protect nanomaterial workers from potential risks of adverse health effects. This article provides and examines timelines for major functional areas (toxicology, metrology, exposure assessment, engineering controls and personal protective equipment, risk assessment, risk management, medical surveillance, and epidemiology) to identify...
Ecotoxicologie des nanomatériaux
Nouvelles approches analytiques Quatre ans après la publication de la note ayant pour titre « Écotoxicologie des nanoparticules : avancées méthodologiques dans l'évaluation des risques» (1), cette note a pour objectif de refaire le bilan sur les progrès réalisés dans le domaine. En effet, la période de veille écoulée a été marquée par la publication de nombreuses revues de la littérature contenant notamment le mot-clef « analytical » : concept analytique, approche...
Reproductive and developmental toxicity of carbon-based nanomaterials
A literature review We summarized the findings of reproductive and developmental toxicity studies on carbon-based nanomaterials (CNMs). Placental transfer of fullerenes in rats and single-walled (SW) and multi-walled (MW) CNTs in mice was shown after intravenous injection. SWCNTs appeared to be embryolethal and teratogenic in mice when given by intravenous injection and induced death and growth retardation in chicken embryos. In mice-administered MWCNTs, fetal malformations after intravenous and intraperitoneal injections and intratracheal instillation, fetal loss after intravenous injection, behavioral...
Occupational Exposure to Carbon Nanotubes and Nanofibers : Current Intelligence Bulletin 65
This NIOSH Current Intelligence Bulletin (1) reviews the animal and other toxicological data relevant to assessing the potential non-malignant adverse respiratory effects of CNT and CNF, (2) provides a quantitative risk assessment based on animal dose-response data, (3) proposes a recommended exposure limit (REL) of 1 μg/m3 elemental carbon as a respirable mass 8-hour time-weighted average (TWA) concentration, and (4) describes strategies for controlling workplace exposures and implementing a medical surveillance program. The NIOSH REL is expected to reduce the risk for pulmonary inflammation...
New HSE guidance on Nanotechnology and updated website
HSE has produced new guidance aimed at employers, health and safety managers and SMEs who use or manufacture nanomaterials. The guidance is based on the generic principles of COSHH and good control practice and includes information on a range of nanomaterials. The nanotechnology website has also been updated and now includes information on the toxicological properties of nanomaterials. Source : http://www.hse.gov.uk/nanotechnology/index.htm?eban=rss -
Filling the Knowledge Gaps for Safe Nanotechnology in the Workplace
A Progress Report from the NIOSH Nanotechnology Research Center, 2004–2011. This 2012 update presents the program accomplishments of the NTRC from its inception in 2004 through 2011. It includes an analysis of the progress made toward accomplishing the goals and objectives of the NIOSH Strategic Plan for Nanotechnology Research and toward addressing the goals and research needs identified in the U.S. National Nanotechnology Initiative (NNI) Environmental, Health, and Safety (EHS) research strategy. Source : http://osha.europa.eu/en/news/int-filling-the-knowledge-gaps-for-safe-nanotechnology...
Risks and Control of Nanomaterials
Editorial / Trevor Ogden. In this issue we bring together 12 articles on nanomaterials and approaches to risk control. The issue originated with the conference held in April (2011) by the Institut National de Recherche et de Sécurité (INRS) in Nancy, France, on risks associated with nanoparticles and nanomaterials. Topics included measurement and control process design, occupational toxicology, protection, epidemiology, assessment and management of risk of nanoparticles. Source : http://annhyg.oxfordjournals.org/content/56/5/489.full
New ISO Technical Report Guides Characterization of Nanomaterials in Toxicology
The International Organization for Standardization (ISO) recently published a Technical Report (TR) that provides guidance on the physicochemical characterization of manufactured nano-objects prior to toxicological assessment. ISO TR 13014:2012 , Nanotechnologies - Guidance on physicochemical characterization of engineered nanoscale materials for toxicologic assessment, is intended to assist health scientists and experts to understand, plan, identify, and address relevant physicochemical characteristics of nano-objects before conducting toxicological tests on them. Source : http://www.ansi.org...
Conférence INRS Nano 2011 : actes
L'INRS a organisé en avril 2011 une conférence scientifique consacrée aux risques liés aux nanomatériaux et nanoparticules. Les actes sont désormais disponibles. Cette conférence, organisée en partenariat avec le réseau européen PEROSH (Partnership for European Research in Occupational Safety and Health) se voulait un lieu de rencontre entre chercheurs, experts, préventeurs, médecins venant d'horizons différents, afin de partager les connaissances les plus récentes et de discuter des besoins...
Quelle est la toxicité des nanoparticules ?
Une nouvelle norme ISO en facilite la détermination Du fait de leur essor rapide, la sécurité et l'effet sur l'environnement des produits issus des nanotechnologies sont pour les chercheurs, les fabricants, les organismes de réglementation et les consommateurs des sujets de préoccupation grandissants. Dans ce contexte, l'ISO a publié une Norme internationale à l'appui des essais de toxicité par inhalation de nanoparticules. Les nanotechnologies ont un potentiel immense et couvrent un large éventail d'applications...
Nano Trust project
The review under the NanoTrust project summarises findings related to silver compounds and their use in nano state. Silver has a rich history of use in medicine and hygiene due to its broad-spectrum toxicity to bacteria, fungi and algae. Silver has been used increasingly in its nano-particulate form, which, according to the review, exhibits an elevated toxic potential compared to traditional silver compounds. Products containing nanosilver are one of the most important classes of nanoproducts. Nanosilver coatings on medical devices are used in hospital settings. In addition, items containing nanosilver...
Les nanoparticules de synthèse - Connaissances actuelles sur les risques et les mesures de prévention en SST
La nanotechnologie est un domaine en pleine effervescence et de nouveaux produits contenant des nanoparticules sont mis en marché chaque semaine. On en compte déjà plus de 800 qui sont commercialement disponibles. Or, le développement de ces nanoparticules, leur préparation industrielle et leur intégration dans différents produits impliquent déjà une exposition professionnelle potentielle de centaines de travailleurs québécois. De nouvelles entreprises québécoises introduisent ce domaine, accroissant du fait...

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