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Mutagenicity of Stereochemical Configurations of 1,3-Butadiene Epoxy Metabolites in Human Cells
This report describes a study by Dr. Ryan Meng and colleagues to determine the role of stereochemistry in the cytotoxicity and mutagenicity of three major butadiene metabolites. This study is a part of HEI's program of research in air toxics; one important aim of that program has been to fill key gaps in risk assessment for some of the most important chemicals. Butadiene is present in motor vehicle exhaust and other emissions and is listed by the U.S. Environmental Protection Agency among the mobile-source air toxics that, because of their emissions and reported toxicity, pose a possible health...
Reducing Cytotoxic Drug Exposure in Healthcare: Determinants Influencing Cleaning Effectiveness
Many cytotoxic drugs used to treat cancer and other diseases are known to be carcinogenic or mutagenic. Health care workers who handle these drugs may be at risk of developing adverse health effects such as organ toxicities, reproductive problems, tumours, and cancer. Although several guidelines for cytotoxic drug handling exist, studies have shown that contamination can occur even when proper engineering controls are in place. Using laboratory research methods, this project examined the effectiveness of the cleaning agents used to clean surfaces contaminated with the three cytotoxic drugs most...

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