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Comparison of Inhalation and Intratracheal Instillation as Testing Methods for Characterisation of Granular Biopersistent Particles (GBP)
Comparison of bronchoalveolar lavage fluid (BALF) data The comparison of the inflammatory potency of the 6 GBP candidates came out with a good accordance of the polymorphonuclear neutrophil (PMN) levels in the differential cell count for µ-TiO2. On day 3 post-treatment, PMN were not increased statistically significantly in the low and high dose groups, neither after instillation nor after inhalation. Thus, a very low inflammogenicity confirmed µ-TiO2 as GBP. µ-BaSO4 (low dose groups) showed a behaviour similar to µ-TiO2. However, for nano-TiO2 P25 an evident difference was...

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