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Study on reprotoxic chemicals
A range of legislative instruments are in place at EU level to manage and minimise the risks from occupational exposure to carcinogenic, mutagenic and reprotoxic substances. Carcinogenic chemicals can cause or promote cancers. Mutagenic chemicals can cause genetic mutations. Reprotoxic chemicals can damage the reproductive process. This study assesses a number of options for moderning the current EU legislation, in particular regarding reprotoxic chemicals Source: https://ec.europa.eu/social/main.jsp?catId=738&langId=en&pubId=8220&furtherPubs=yes
Dioxyde de titane sous forme nanoparticulaire : l’Anses définit une Valeur Toxicologique de Référence (VTR) pour l’exposition chronique par inhalation
Le dioxyde de titane sous forme nanoparticulaire est utilisé dans de nombreuses applications industrielles et commerciales. Dans le cadre de sa mission nationale d'élaboration de valeurs sanitaires de référence, l'Anses a été chargée de définir une Valeur Toxicologique de Référence (VTR) pour le dioxyde de titane sous forme nanoparticulaire (TiO 2 -NP). Suite à une analyse approfondie de l'ensemble des données de toxicité disponibles, l'Agence recommande une VTR chronique par inhalation pour...
Agents fibrogènes et cancérogènes dans les mines d’or et de fer du Québec - Étude exploratoire
De récentes études ont mis en évidence que les travailleurs des mines d’or du Dakota et des mines de fer du Minnesota sont exposés à des particules minérales allongées (PMA). En particulier, les mineurs du Minnesota présentent un risque plus élevé de décès par cancer du poumon, par mésothéliome et par maladies cardiaques que la population générale. Comme l’intérêt renouvelé pour l’exploration de nouveaux gisements d’or et de fer dans le Nord...
Literature study on the uses and risks of nanomaterials as pigments in the European Union
This report provides a review on the safe use of nano-sized pigments when used by professionals, workers or consumers. Extensive literature searches were carried out in combination with analyses of data from national nano-inventories to capture the current state of play. The report provides a list of nano-sized pigments currently identified on the EU market and discusses potential risks arising from their use in paints, coatings, printer toner cartridges, personal care products, tattooes as well as other potential uses of nanopigments. Data for hazard and risk assessment are not available for the...
Welding, Molybdenum Trioxide, and Indium Tin Oxide
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 118 This volume of the IARC Monographs provides evaluations of the carcinogenicity of welding and welding fumes, molybdenum trioxide, and indium tin oxide. Worldwide, an estimated 11 million workers have a job title of welder, and around 110 million additional workers probably incur welding-related exposures. Welding can involve exposures to fumes, gases, ultraviolet radiation and electromagnetic fields, and co-exposures to asbestos and solvents. The extent and type of exposure can depend on the process used, the material...
Soignants et médicaments cytotoxiques
Place de la biométrologie dans la maîtrise des risques dans le temps Les médicaments cytotoxiques utilisés dans les traitements des cancers présentent une toxicité intrinsèque, du fait de leurs propriétés génotoxiques, tératogènes et cancérigènes. Les professionnels de santé pouvant y être exposés, il est essentiel de garantir leur sécurité et de mettre en place des programmes d'évaluation des expositions pour documenter les expositions, juger de l'efficacité...
L’Anses met à disposition une base de données sur plus de 500 valeurs toxicologiques de référence
L'Agence poursuit depuis 2004 la réalisation d'un programme national sur les valeurs toxicologiques de référence (VTR). Les VTR sont des indicateurs biologiques qui permettent de qualifier ou quantifier sur une base scientifique un risque pour la santé humaine lié à l'exposition à une substance chimique. Elles sont utiles pour les différents acteurs de la gouvernance des risques : entreprises, expertise publique et autorités chargées de la gestion du risque. L'Anses publie une base de données regroupant...
IARC Monographs Volume 112: Some Organophosphate Insecticides and Herbicides
This volume of the IARC Monographs provides evaluations of the carcinogenicity of some organophosphate insecticides and herbicides, including diazinon, glyphosate, malathion, parathion, and tetrachlorvinphos. Diazinon acts on a wide range of insects on crops, gardens, livestock, and pets, but most uses have been restricted in the USA, Canada, and the European Union since the 1980s. Glyphosate is the most heavily used agricultural and residential herbicide in the world, and has been detected in soil, air, surface water, and groundwater, as well as in food. Malathion is one of the oldest and most...
Summary of evidence – Solvent-based hydrophobic coatings and risks for acute respiratory toxicity
Water repellent coatings are increasingly used by different industries to reduce water and dirt sticking to surfaces. The coatings can be applied by processes that minimise the risk that operators inhale the product but there is evidence that some products are applied by spraying, creating an inhalable mist. This review examined evidence about these coatings and whether lung disease occurs when applied by spraying. Scientific studies on the hazardous properties of these products, and clinical studies reporting lung disease in people using them, were considered. A consistent finding was that some...
IARC Monographs Volume 111: Some Nanomaterials and Some Fibres
This volume of the IARC Monographs contains evaluations of the carcinogenic hazard to humans of fluoro-edenite fibrous amphibole, silicon carbide fibres and whiskers, and carbon nanotubes. None of these agents had been evaluated previously by the Working Group. Source: http://monographs.iarc.fr/ENG/Monographs/vol111/index.php
Chromosomal aberrations, sister chromatid exchanges, and micronuclei in lymphocytes of oncology department personnel handling anti-neoplastic drugs
Objective: Concern exists regarding the possible hazards to the personnel handling anti-neoplastic drugs. The purpose of the present study was to assess the genotoxicity induced by anti-neoplastic agents in oncology department personnel. Materials and methods: To do this, the frequency of chromosomal aberrations (CAs) induced in peripheral blood lymphocytes was assessed at G0 phase of the cell cycle using metaphase analysis, cytokinesis block-micronucleus (MN) assay and sister chromatid exchange (SCE) assay. These cytogenetic end points were measured among 71 nurses in oncology department and 10...
History of knowledge and evolution of occupational health and regulatory aspects of asbestos exposure science: 1900–1975
The understanding by industrial hygienists of the hazards of asbestos and appropriate ways to characterize and control exposure has evolved over the years. Here, a detailed analysis of the evolution of industrial hygiene practices regarding asbestos and its health risks, from the early 1900s until the advent of the national occupational health and safety regulatory structure currently in place in the US (early-to-mid 1970s) is presented. While industrial hygienists recognized in the early 1900s that chronic and high-level exposures to airborne concentrations of asbestos could pose a serious health...
Occupational Exposure to Diacetyl and 2,3-Pentanedione
Diacetyl and its substitute, 2,3-pentanedione, are widely used as flavoring compounds. The National Institute for Occupational Safety and Health (NIOSH) objective in establishing recommended exposure limits (RELs) for diacetyl and 2,3-pentanedione is to reduce the risk of respiratory impairment (decreased lung function) and the severe irreversible lung disease obliterative bronchiolitis associated with occupational exposure. In this Criteria Document, NIOSH reviews the scientific literature concerning potential health effects, toxicology, and risk assessment pertaining to diacetyl and 2,3-pentanedione...
Prévenir les risques chimiques lors d'une chimiothérapie intrapéritonéale pressurisée par aérosolisation (CIPPA ou PIPAC)
Une équipe de la faculté de médecine de l'Université de la Ruhr, à Bochum en Allemagne, a récemment mis au point une nouvelle technique de chimiothérapie intrapéritonéale : la chimiothérapie intrapéritonéale pressurisée par aérosolisation (CIPPA, PIPAC en anglais). Cette procédure, apparentée à la chimiothérapie hyperthermique intrapéritonéale (CHIP) utilisée depuis plusieurs années, offre de nouvelles perspectives pour la prise en charge...
Manipulation des anticorps monoclonaux (Acm) en milieu de soins
Pratiques et mesures de prévention L'essor des anticorps monoclonaux (Acm) pose la question de la prévention à mettre en place pour le personnel qui les manipule. Un état des lieux des pratiques et des mesures de prévention est réalisé en milieu de soins pour dégager des pistes d'amélioration. Les données retrouvées dans la littérature sont limitées et la toxicité professionnelle des Acm mal connue. Une enquête est menée auprès du personnel manipulant des Acm et auprès...
Australian Work Exposure Study (AWES) - Carcinogen Exposures Construction Industry
A random, population-based sample of 5528 Australian workers participated in the Australian Work Exposure Study (AWES). Workers answered questions about the tasks they completed and the controls used at work. Based on their responses to those questions, the likelihood of exposure to 38 known or suspected carcinogens was estimated. The AWES focused on the most common tasks performed at work. Workers were not asked directly about their exposures to carcinogens and exposure levels were not measured in the workplace. This report describes the responses provided by 459 AWES participants categorised...
Australian Work Exposures Study (AWES) - Carcinogen Exposures Manufacturing Industry
A random, population-based sample of 5528 Australian workers participated in the Australian Work Exposure Study (AWES). Workers answered questions about the tasks they completed and the controls used at work. Based on their responses to those questions, the likelihood of exposure to 38 known or suspected carcinogens was estimated. The AWES focused on the most common tasks performed at work. Workers were not asked directly about their exposures to carcinogens and exposure levels were not measured in the workplace. This report describes the responses provided by 281 AWES participants categorised...
Reproductive and developmental toxicity of carbon-based nanomaterials
A literature review We summarized the findings of reproductive and developmental toxicity studies on carbon-based nanomaterials (CNMs). Placental transfer of fullerenes in rats and single-walled (SW) and multi-walled (MW) CNTs in mice was shown after intravenous injection. SWCNTs appeared to be embryolethal and teratogenic in mice when given by intravenous injection and induced death and growth retardation in chicken embryos. In mice-administered MWCNTs, fetal malformations after intravenous and intraperitoneal injections and intratracheal instillation, fetal loss after intravenous injection, behavioral...
Neurotoxicity associated with exposure to 1-bromopropane in golf-club cleansing workers
BACKGROUND: 1-Bromopropane (1-BP) is an alternative to ozone-depleting solvent that is used in degreasing, dry cleaning, spray adhesives, and aerosol solvents. Occupational exposure to 1-BP is associated with adverse peripheral sensory, motor, and central nervous system (CNS) effects. We report our Health Hazard and Medical Evaluation of 6 patients with neurotoxicity associated with occupational exposure to 1-BP. Case series and environmental evaluation. Six workers, 1 male and 5 female, were exposed to high ambient 1-BP concentrations while employed in a golf club cleaning factory. 1-BP was identified...
IARC evaluation of five organophosphate pesticides
A Working Group of 17 experts from 11 countries met at the International Agency for Research on Cancer (IARC), the specialized cancer agency of the World Health Organization on 3-10 March 2015 to review the available published scientific evidence and evaluate the carcinogenicity of five organophosphate insecticides and herbicides: diazinon, glyphosate, malathion, parathion, and tetrachlorvinphos. A summary of the final evaluations together with a short rationale have now been published online in The Lancet Oncology , and the detailed assessments will be published as Volume 112 of the IARC Monographs...
Australian Work Exposures Study (AWES) - Polycyclic aromatic hydrocarbons (PAHs)
The Australian Work Health and Safety Strategy 2012-2022 (the Strategy) describes work-related cancer as a priority disorder and understanding current hazardous exposures and the effectiveness of controls as a research priority. The Australian Work Exposures Study (AWES) was a national survey that investigated work-related exposures among Australian workers to 38 agents classified by the International Agency for Research on Cancer (IARC) as known or suspected carcinogens. Some polycyclic aromatic hydrocarbons (PAHs) are classified as a known or suspected human carcinogens by the IARC and the work...
Australian Work Exposures Study (AWES) - Formaldehyde
The Australian Work Health and Safety Strategy 2012-2022 (the Strategy) describes work-related cancer as a priority disorder and understanding current hazardous exposures and the effectiveness of controls as a research priority. The Australian Work Exposures Study (AWES) was a national survey that investigated work-related exposures among Australian workers to 38 agents classified by the International Agency for Research on Cancer (IARC) as known or suspected carcinogens. Formaldehyde is classified as a known human carcinogen by the IARC and the work described in this report uses AWES data to:...
Australian Work Exposures Study (AWES) - Lead and lead compounds
The Australian Work Health and Safety Strategy 2012-2022 (the Strategy) describes work-related cancer as a priority disorder and understanding current hazardous exposures and the effectiveness of controls as a research priority. The Australian Work Exposures Study (AWES) was a national survey that investigated work-related exposures among Australian workers to 38 agents classified by the International Agency for Research on Cancer (IARC) as known or suspected carcinogens. Some forms of lead are considered to be probable carcinogens and the work described in this report uses AWES data to: •...
List of MAK and BAT Values 2014
Maximum Concentrations and Biological Tolerance Values at the Workplace MAK values (Maximum Concentrations at the Workplace) and BAT values (Biological Tolerance Values) promote the protection of health at the workplace. They are an efficient indicator for the toxic potential of chemical compounds. This book contains a list of scientifically recommended threshold limit values for more than 1000 chemical compounds. Carcinogens, germ cell mutagens, embryotoxicants, sensitizing substances and those potentially bearing a risk to pregnancy are treated separately. Of particular value are the lists of...
Exposition aux mélanges de substances chimiques
Quels défis pour la recherche et l'évaluation des risques ? L'agence sanitaire française -Anses- et les instituts allemand -BfR- et danois -DTU- ont organisé conjointement, les 10 et 11 décembre 2013, une conférence internationale sur les effets de l'exposition aux mélanges de substances chimiques et l'évaluation des risques, une préoccupation majeure pour de nombreux pays dans le monde et un véritable défi scientifique à relever. L'objectif de ces deux jours était de promouvoir les échanges...
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