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The Occupational Burden of Nonmalignant Respiratory Diseases
An Official American Thoracic Society and European Respiratory Society Statement Rationale: Workplace inhalational hazards remain common worldwide, even though they are ameliorable. Previous American Thoracic Society documents have assessed the contribution of workplace exposures to asthma and chronic obstructive pulmonary disease on a population level, but not to other chronic respiratory diseases. The goal of this document is to report an in-depth literature review and data synthesis of the occupational contribution to the burden of the major nonmalignant respiratory diseases, including airway...
Heme oxygenase 1 polymorphism, occupational vapor, gas, dust, and fume exposure and chronic obstructive pulmonary disease in a Danish population-based study
Objectives: The number of dinucleotide repeats (GT)n modulate expression of heme oxygenase 1 (HMOX1), a stress response gene. Multiple repeats might affect chronic obstructive pulmonary disease (COPD) susceptibility. We aimed to investigate the association of this polymorphism with COPD and its interaction with occupational exposures (vapor, gas, dust, or fumes). Methods: This population-based cross-sectional study included 4703 Danes, aged 45–84 years. HMOX1 (GT)n was genotyped and grouped as short: ≤26, medium: 27–32 and long: ≥33 alleles. COPD was defined by the lower limit...
Study on reprotoxic chemicals
A range of legislative instruments are in place at EU level to manage and minimise the risks from occupational exposure to carcinogenic, mutagenic and reprotoxic substances. Carcinogenic chemicals can cause or promote cancers. Mutagenic chemicals can cause genetic mutations. Reprotoxic chemicals can damage the reproductive process. This study assesses a number of options for moderning the current EU legislation, in particular regarding reprotoxic chemicals Source: https://ec.europa.eu/social/main.jsp?catId=738&langId=en&pubId=8220&furtherPubs=yes
Programme national de surveillance du mésothéliome pleural (PNSM)
Vingt années de surveillance (1998-2017) des cas de mésothéliome, de leurs expositions et des processus d'indemnisation En 1998, la Direction générale du travail (DGT) et la Direction générale de la santé (DGS) des ministères respectifs ont saisi Santé publique France pour mettre en place un programme national de surveillance des effets sanitaires de l'amiante : le programme national de surveillance du mésothéliome pleural (PNSM), marqueur spécifique des expositions passées à l'amiante...
Effects of occupational exposure to respirable quartz dust on acute myocardial infarction
Objectives: The aim of this study is to investigate the effects of occupational exposure to respirable quartz (RQ) on first acute myocardial infarction (AMI). RQ causes pulmonary diseases like silicosis and has also been linked to cardiovascular diseases. Inflammation is hypothesised as the underlying pathway. Methods: We performed a 1:3 matched case–control study nested in a cohort of male uranium miners. We included cases (identified from hospital records and validated according to WHO criteria) who had suffered their first AMI while still employed and <65 years of age. Controls were...
Description par type de cancer des situations professionnelles à risque : synthèse des données du réseau RNV3P
L'ANSES (Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail) et le RNV3P (Réseau National de Vigilance et de Prévention des Pathologies Professionnelles) mettent en ligne un rapport identifiant les situations professionnelles à risque pour plusieurs types de cancers. Sont abordés les cancers broncho-pulmonaires, les cancers urothéliaux, les hémopathies lymphoïdes matures, les leucémies myéloïdes, le cancer du larynx, le cancer des fosses nasales et des sinus, le cancer...
NIOSH Reviews Scientific Literature on Infectious Diseases in the Workplace
NIOSH recently published a study conducting a review of infectious disease investigations in workplaces across the United States to better understand the range of cases, the risk factors for workers, and the ways to prevent infectious disease transmission on the job. Source : https://wwwnc.cdc.gov/eid/article/25/3/18-0708_article
Risques pour l’audition d’une exposition combinée bruit et solvants
Résultats d'étude INRS sur le disulfure de carbone et les bruits impulsionnels. Une étude de l'INRS montre que l'exposition au disulfure de carbone, solvant a priori sans effet ototoxique, et aux bruits impulsionnels (non continus) peut entraîner un risque accru de pertes auditives, ce même en dessous de la valeur limite d'exposition au bruit. D'autres effets réversibles peuvent aussi être observés, comme une augmentation de la fatigue auditive en présence de bruit continu. Ces mécanismes non identifiés...
Improved Ventilation System for Removal of Airborne Contamination in Airborne Infectious Isolation Rooms
The study discussed in this article evaluated the ventilation performance of three strategies for HVAC control for airborne infectious diseases induced by contaminated exhaled air from patients in an airborne infectious isolation room (AIIR). This article examines airflow path and airborne pollutant distribution by computational fluid dynamics modeling and field measurement. In hospitals, the risk of airborne virus diffusion mainly depends on airflow behavior and changes in direction caused by supply air and exhaust air locations. An improved isolation room ventilation strategy has been developed...
NIOSH Reviews Scientific Literature on Infectious Diseases in the Workplace
It may be obvious when people get injured at work, but it may not always be apparent when people acquire infections resulting from exposures at work. The National Institute for Occupational Safety and Health (NIOSH) recently published a study conducting a review of infectious disease investigations in U.S. workplaces to better understand the range of cases, the risk factors for workers, and the ways to prevent infectious disease transmission on the job. Source : https://wwwnc.cdc.gov/eid/article/25/3/18-0708_article
Sinistralité et repérage des cancers professionnels dans neuf pays européens
EUROGIP publie un nouveau rapport dont les données portent sur l'Allemagne, l'Autriche, la Belgique, le Danemark, la Finlande, la France, l'Italie, la Suède, la Suisse. Les cas (déclarations et reconnaissances) de cancers depuis 2005 sont relativement stables au Danemark, en Belgique, France, Italie et Suède, mais en augmentation en Autriche, Allemagne et Suisse. Pour cette dernière catégorie, les raisons sont diverses, comme l'inscription du cancer de la peau en Allemagne en 2015 sur la liste nationale des MP. Dans tous les pays à...
NIOSH Skin Notation Profiles: Atrazine
As the largest organ of the body, the skin performs multiple critical functions, such as serving as the primary barrier to the external environment. For this reason, the skin is often exposed to potentially hazardous agents, including chemicals, which may contribute to the onset of a spectrum of adverse health effects ranging from localized damage (such as irritant contact dermatitis and corrosion) to induction of immune-mediated responses (such as allergic contact dermatitis and pulmonary responses), or systemic toxicity (such as neurotoxicity and hepatotoxicity). Understanding the hazards related...
Agents fibrogènes et cancérogènes dans les mines d’or et de fer du Québec - Étude exploratoire
De récentes études ont mis en évidence que les travailleurs des mines d’or du Dakota et des mines de fer du Minnesota sont exposés à des particules minérales allongées (PMA). En particulier, les mineurs du Minnesota présentent un risque plus élevé de décès par cancer du poumon, par mésothéliome et par maladies cardiaques que la population générale. Comme l’intérêt renouvelé pour l’exploration de nouveaux gisements d’or et de fer dans le Nord...
Exposure-response relationships for silicosis and its progression in industrial sand workers
Objectives: This study aimed to characterize the relationship between radiographic silicosis and exposure to respirable quartz and determine how exposure affects disease progression. Methods: Surveillance chest radiographs from a cohort of 1902 workers were examined to identify 67 cases of radiographic silicosis and 167 matched controls. Exposures were estimated by linking work histories to a job exposure matrix (JEM) based on samples collected by the participating companies and historical estimates. Conditional logistic regression was used to examine exposure-response relationships. Sequential...
Cancer de la vessie et expositions professionnelles aux fluides de coupe
Étude épidémiologique parmi les travailleurs de la sidérurgie en France L'objectif de cette étude est de rechercher s'il existe un risque de cancer de la vessie associé à des expositions professionnelles à des brouillards d'huiles, issus de l'utilisation d'huiles entières ou de fluides aqueux. Une étude cas-témoins a été mise en place au sein d'une cohorte de 22 795 travailleurs de la sidérurgie du Nord - Pas-de-Calais. Les cas de cancer de vessie ont été diagnostiqués...
Occupational exposure to benzene, toluene, xylene and styrene and risk of prostate cancer in a population-based study
Objectives: While several monocyclic aromatic hydrocarbons are classified as definite or possible carcinogens to humans, little data exist on their role in prostate cancer (PCa). We examined occupational exposure to benzene, toluene, xylene (BTX) and styrene and PCa risk in a population-based case–control study in Montreal, Canada. Methods: Cases aged ≤75 years diagnosed with PCa in 2005–2009 (n=1920) and population controls frequency-matched on age (n=1989) provided detailed work histories. Experts evaluated the certainty, frequency and concentration of exposure to monocyclic aromatic...
Priorisation des zoonoses au Québec dans un contexte d’adaptation aux changements climatiques à l’aide d’un outil d’aide à la décision multicritère
Au Québec comme ailleurs dans le monde, les maladies transmises entre les animaux et les humains (zoonoses) sont en émergence, notamment du fait des changements climatiques. Elles représentent environ 60 % des maladies infectieuses émergentes chez l'humain. Devant les enjeux zoonotiques qui se multiplient, l'Observatoire multipartite québécois sur les zoonoses et l'adaptation aux changements climatiques (Observatoire) a initié en 2015 une démarche de priorisation des zoonoses, afin d'orienter les besoins en recherche et les...
Potential Health Risk of Endocrine Disruptors in Construction Sector and Plastics Industry
A New Paradigm in Occupational Health Endocrine disruptors (EDs) belong to large and diverse groups of agents that may cause multiple biological effects associated with, for example, hormone imbalance and infertility, chronic diseases such as diabetes, genome damage and cancer. The health risks related with the exposure to EDs are typically underestimated, less well characterized, and not regulated to the same extent as, for example, carcinogens. The increased production and utilization of identified or suspected EDs in many different technological processes raises new challenges with respect to...
Expositions professionnelles à des agents cancérogènes respiratoires chez les salariés en 2010
Introduction – Les cancers respiratoires sont les plus fréquents des cancers professionnels, mais très peu de données sont disponibles pour quantifier l'exposition professionnelle aux cancérogènes respiratoires. L'objectif de ce travail était d'évaluer en France la proportion de salariés exposés à des agents cancérogènes respiratoires et d'identifier les groupes professionnels les plus exposés, à des fins de prévention. Méthode – À partir des données...
Cleaning at Home and at Work in Relation to Lung Function Decline and Airway Obstruction
Rationale: Cleaning tasks may imply exposure to chemical agents with potential harmful effects to the respiratory system, and increased risk of asthma and respiratory symptoms among professional cleaners and in persons cleaning at home has been reported. Long-term consequences of cleaning agents on respiratory health are, however, not well described. Objectives: This study aimed to investigate long-term effects of occupational cleaning and cleaning at home on lung function decline and airway obstruction. Methods: The European Community Respiratory Health Survey (ECRHS) investigated a multicenter...
Association of Parkinson’s disease with industry sectors
A French nationwide incidence study In order to identify working environments at risk for Parkinson's disease (PD), we investigated the relation between the importance of industry sectors, used as a surrogate for occupational exposures, and PD incidence in French cantons. The number of incident PD cases (2010–2014) in 3689 cantons of metropolitan France was determined using drug claims from French National Health Insurance databases. The proportions of workers in 38 industry sectors in 2006 were calculated for each canton. Associations between the proportions of workers in industry sectors...
Treatments to prevent hand skin irritation in the workplace
Occupational irritant hand dermatitis (OIHD) is a skin disease that occurs on the hands of employees in certain jobs. The first signs are red and scaly patches in the finger webs and on the knuckle area of the hands. Itchy blisters, painful cracks, and possibly infection are common, and eventually the skin becomes thickened. Hand skin irritation can affect employees who regularly come into contact with water, detergents, chemicals, and other irritants, or who wear gloves during their working day. People at particular risk include hairdressers, nurses, cleaners, builders, and people who work in...
Case-control investigation of occupational exposure to chlorinated solvents and non-Hodgkin’s lymphoma
Objectives: Although many studies have investigated the association between trichloroethylene (TCE) exposure and non-Hodgkin's lymphoma (NHL), less is known about other chlorinated solvents. We extended our previous analysis of occupational TCE exposure in a multicentre population-based case-control study of NHL to investigate associations with five additional chlorinated solvents: 1,1,1,-trichloroethane, carbon tetrachloride, chloroform, methylene chloride and perchloroethylene. Methods: Cases (n=1189) and controls (n=982) provided detailed information on their occupational histories and workplace...
Interventions for preventing occupational irritant hand dermatitis
Background: Occupational irritant hand dermatitis (OIHD) causes significant functional impairment, disruption of work, and discomfort in the working population. Different preventive measures such as protective gloves, barrier creams and moisturisers can be used, but it is not clear how effective these are. This is an update of a Cochrane review which was previously published in 2010. Objectives: To assess the effects of primary preventive interventions and strategies (physical and behavioural) for preventing OIHD in healthy people (who have no hand dermatitis) who work in occupations where the...
Burden of lung cancer attributable to occupational diesel engine exhaust exposure in Canada
Objective: To estimate the population attributable fraction (PAF) and number of incident and fatal lung cancers in Canada from occupational exposure to diesel engine exhaust (DEE). Methods: DEE exposure prevalence and level estimates were used with Canadian Census and Labour Force Survey data to model the exposed population across the risk exposure period (REP, 1961–2001). Relative risks of lung cancer were calculated based on a meta-regression selected from the literature. PAFs were calculated using Levin's equation and applied to the 2011 lung cancer statistics obtained from the Canadian...
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