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Study on reprotoxic chemicals
A range of legislative instruments are in place at EU level to manage and minimise the risks from occupational exposure to carcinogenic, mutagenic and reprotoxic substances. Carcinogenic chemicals can cause or promote cancers. Mutagenic chemicals can cause genetic mutations. Reprotoxic chemicals can damage the reproductive process. This study assesses a number of options for moderning the current EU legislation, in particular regarding reprotoxic chemicals Source: https://ec.europa.eu/social/main.jsp?catId=738&langId=en&pubId=8220&furtherPubs=yes
State-of-the-art report on reproductive toxicants
Summary Workers' reproductive health can be put at risk by hazardous chemicals, such as pesticides and pharmaceuticals, as well as biological, physical, organisational and psychosocial factors. The issue of reproductive OSH risks has largely been focused on women, and mostly pregnant women, but reprotoxic risks can in fact affect both women's and men's reproductive health. Reprotoxicants can also affect foetal and human development and effects include miscarriages, malformations and functional deficits. The summary presents in short the results of a report that examines the current...
Occupational use of high-level disinfectants and fecundity among nurses
Objective: This study aimed to examine the relationship between occupational use of high-level disinfectants (HLD) and fecundity among female nurses. Methods: Women currently employed outside the home and trying to get pregnant (N=1739) in the Nurses' Health Study 3 cohort (2010–2014) were included in this analysis. Occupational exposure to HLD used to disinfect medical instruments and use of protective equipment (PE) was self-reported on the baseline questionnaire. Every six months thereafter women reported the duration of their ongoing pregnancy attempt. Multivariable accelerated failure...
Perturbateurs endocriniens
Contexte, dangers, sources d'exposition et prévention des risques en milieu professionnel Les perturbateurs endocriniens (PE) sont des substances chimiques ou des mélanges, d'origine naturelle ou artificielle, susceptibles de modifier le fonctionnement du système endocrinien. Les PE avérés ou suspectés tels que bisphénols, phtalates, parabènes, polychlorobiphényles, polybromés, perfluorés, pesticides... sont retrouvés dans de nombreux secteurs d'activité. Ils sont caractérisés par...
Perturbateurs endocriniens: un risque professionnel à (re)connaître
Ce guide s'adresse aux représentants de travailleurs, en particulier aux élus des comités de santé, de sécurité et d'hygiène, potentiellement exposés aux perturbateurs endocriniens sur leur lieu de travail. Il a pour objectif de dresser un état des lieux des connaissances scientifiques sur les conséquences sanitaires de l'exposition des travailleurs aux substances chimiques ayant des effets sur le système endocrinien. Source: http://www.etui.org/fr/Publications2/Guides/Perturbateurs-endocriniens-un-risque-professionnel...
The Effects of Occupational Exposure of Carbon Disulfide on Sexual Hormones and Semen Quality of Male Workers From a Chemical Fiber Factory
Objective: This study is aimed to analyze the relationship between occupational CS2 exposure and reproductive impairments. Methods: Seventy-six CS2-exposed (9.73?±?2.76?mg/m3) male workers and 94 unexposed workers were selected for study. Worker demographics were assessed with a customized questionnaire. Sexual hormones and sperm-related parameters were measured by biochemical or morphological analysis. Results: The CS2-exposed workers had significantly higher serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and lower levels of testosterone (T). Significant...
Perturbateurs endocriniens
Le colloque INRS/AISS 2016 « Perturbateurs endocriniens et agents sensibilisants : quels risques au travail ? quelle prévention ? » s'est tenu début juin à Paris. Les perturbateurs endocriniens, qui ont la capacité d'interférer avec le système hormonal, sont susceptibles de provoquer des effets nocifs tant chez les individus exposés que sur leur descendance. Ils constituent à la fois un sujet de santé publique et une problématique de santé au travail. En milieu professionnel, les salariés peuvent...
Prostate cancer risk among French farmers in the AGRICAN cohort
Objectives: Prostate cancer is one of the most frequent cancers among men worldwide. Its etiology is largely unknown, but an increased risk has been repeatedly observed among farmers. Our aim was to identify occupational risk factors for prostate cancer among farmers in the prospective cohort study AGRICAN. Methods: Data on lifetime agricultural exposures (type of crops, livestock and tasks including pesticide use, re-entry and harvesting) were collected from the enrolment questionnaire. During the period from enrolment (2005–2007) to 31 December 2009, 1672 incident prostate cancers were...
DEMETER : 14 nouvelles fiches publiées
14 nouvelles fiches ont été publiées dans le guide DEMETER (Documents pour l'évaluation médicale des produits toxiques vis-à-vis de la reproduction), qui en contient désormais près de 150. Destiné en particulier aux médecins du travail, ce guide a pour but de fournir une aide à l'évaluation du risque pour la reproduction lors d'exposition d'hommes ou de femmes en milieu professionnel à des produits chimiques. Chaque fiche contient des informations sur les dangers vis-à-vis de la reproduction...
Les expositions aux cancérogènes, mutagènes et reprotoxiques
Un zoom sur huit produits chimiques Les améliorations sont cependant hétérogènes. L'analyse des huit agents CMR qui touchent le plus de salariés montre que l'exposition au formaldéhyde, au plomb, à l'amiante et aux poussières de bois a fortement diminué tandis que celles à d'autres produits comme la silice cristalline ou les phtalates, important reprotoxique, a plutôt augmenté. Les mesures de protections efficaces contre les produits comme les gaz d'échappement diesel ou les huiles minérales...
Reproductive and developmental toxicity of carbon-based nanomaterials
A literature review We summarized the findings of reproductive and developmental toxicity studies on carbon-based nanomaterials (CNMs). Placental transfer of fullerenes in rats and single-walled (SW) and multi-walled (MW) CNTs in mice was shown after intravenous injection. SWCNTs appeared to be embryolethal and teratogenic in mice when given by intravenous injection and induced death and growth retardation in chicken embryos. In mice-administered MWCNTs, fetal malformations after intravenous and intraperitoneal injections and intratracheal instillation, fetal loss after intravenous injection, behavioral...
Miscarriage Among Flight Attendants
Background: Cosmic radiation and circadian disruption are potential reproductive hazards for flight attendants. Methods: Flight attendants from 3 US airlines in 3 cities were interviewed for pregnancy histories and lifestyle, medical, and occupational covariates. We assessed cosmic radiation and circadian disruption from company records of 2 million individual flights. Using Cox regression models, we compared respondents (1) by levels of flight exposures and (2) to teachers from the same cities, to evaluate whether these exposures were associated with miscarriage. Results: Of 2654 women interviewed...
Reproductive Health Risks Associated With Occupational Exposures to Antineoplastic Drugs in Health Care Settings
A Review of the Evidence Objectives: Antineoplastic drugs are known reproductive and developmental toxicants. Our objective was to review the existing literature of reproductive health risks to workers who handle antineoplastic drugs. Methods: A structured literature review of 18 peer-reviewed, English language publications of occupational exposure and reproductive outcomes was performed. Results: Although effect sizes varied with study size and population, occupational exposure to antineoplastic drugs seems to raise the risk of both congenital malformations and miscarriage. Studies of infertility...
Workplace Exposures and the National Action Plan for Infertility
Infertility is a significant health issue in the U.S. as well as globally. In addition to the large health and fiscal impacts of infertility, the inability to conceive can be devastating to individuals or couples. Research suggest that between 12% and 18% of couples struggle with infertility,[1] which may be caused by a wide variety of factors including genetic abnormalities, aging, acute and chronic diseases, treatments for certain conditions, behavioral factors, and exposure to environmental, occupational, and infectious hazards. However, many questions about infertility remain unanswered. Today...
EU-OSHA stimulates debate on workplace risks to reproductivity
Various reproductive hazards can be found at the workplace, not only from chemicals, but also from physical, biological, ergonomic or other factors. While the issue of reproductive risks has largely been stigmatised on women, and mostly pregnant women, these risk factors can in fact affect both women's and men's reproductive health and some may also have effects on their children, even on the long term. Awareness at the workplace level is low and targeted information limited. A workshop organised by EU OSHA in cooperation with the French Agency for Food, Environmental and Occupational Health...
De nouveaux éclairages sur les pesticides
Une expertise collective de l'Inserm apporte de nouveaux éclairages sur les risques liés aux produits pesticides. L'analyse de la littérature scientifique internationale met en évidence des liens entre l'exposition professionnelle aux pesticides et la survenue de certaines pathologies chez l'adulte : maladie de Parkinson, cancer de la prostate, lymphomes, myélomes. L'étude montre également que les expositions intervenant au cours de la grossesse peuvent perturber le développement de l'enfant à naître. Source...
23 nouvelles fiches sur les effets des produits chimiques sur la reproduction : nouveautés de la base Demeter
La base de données Demeter de l’Institut national de recherche et de sécurité (INRS) intègre 23 nouvelles fiches concernant des produits chimiques et leurs effets sur la reproduction, portant à plus de 130 le nombre de références qu’elle contient. La base de données Demeter (Documents pour l’évaluation médicale des produits toxiques vis-à-vis de la reproduction) fournit une synthèse de l’état des connaissances sur les dangers de plus de 130 produits chimiques. Ces fiches sont destinées...
Effects of Paternal Occupation Exposure to Formaldehyde on Reproductive Outcomes
Objective: To investigate whether paternal occupational exposure to formaldehyde (FA) affects the reproductive outcomes. Methods: Data were collected from 302 male workers occupationally exposed to FA and 305 referent controls through interview questionnaires. Formaldehyde exposure level was measured and calculated for every subject. Different reproductive outcomes were compared for two groups by logistic regression analyses. Results: A significant increased risk of prolonged time to pregnancy (P = 0.034; odds ratio, 2.828; 95% confidence interval, 1.081 to 7.406) and significant elevated risk...
Pregnancy Outcomes After Paternal Radiofrequency Field Exposure Aboard Fast Patrol Boats
Objectives: To investigate adverse reproductive outcomes among male employees in the Royal Norwegian Navy exposed to radiofrequency electromagnetic fields aboard fast patrol boats. Methods: Cohort study of Royal Norwegian Navy servicemen linked to the Medical Birth Registry of Norway, including singleton offspring born between 1967 and 2008 (n = 37,920). Exposure during the last 3 months before conception (acute) and exposure more than 3 months before conception (nonacute) were analyzed. Results: Perinatal mortality and preeclampsia increased after service aboard fast patrol boats during an acute...
Relation entre exposition professionnelle, anomalies de la fertilité et troubles de l’appareil reproducteur
Revue de la littérature récente Une revue de la littérature des études publiées depuis janvier 2000 concernant la relation entre l'exposition professionnelle masculine ou féminine et la survenue d'anomalies de la fertilité ou de troubles de l'appareil reproducteur a été réalisée. Ces études rapportent des associations avec les expositions professionnelles masculines ou féminines au plomb et au cadmium à des niveaux d'exposition interne jusque-là considérés comme...
France : les perturbateurs endocriniens dans la ligne de mire du sénat
Cancer du sein ou de la prostate, problèmes d'infertilité, l'augmentation importante des maladies liées au dysfonctionnement du système hormonal inquiète les parlementaires français. Dans un rapport publié le 13 juillet, l'Office parlementaire d'évaluation des choix scientifiques et technologiques (OPECST) rappelle que l'incidence du cancer du sein a doublé en France depuis les années 1980 et que le cancer des testicules a fait de même depuis les années 1970 dans les pays développés...
ECHA adds eight substances to the Candidate List for authorisation
The European Chemicals Agency has added 8 chemical substances to the Candidate List of Substances of Very High Concern (SVHC) for authorisation. Following the unanimous agreement of the Member State Committee, ECHA is adding 8 substances on the Candidate List, which now contains 38 substances in total. The 8 substances, which are carcinogenic, mutagenic or reprotoxic (CMR) substances, are listed below. As foreseen by REACH, a specific procedure will be followed to decide whether the substances should also be included in the authorisation list. Source : http://osha.europa.eu/en/news/eu-echa-adds...
Exploratory survey of Occupational Exposure Limits (OELs)
Exploratory survey of Occupational Exposure Limits (OELs) for Carcinogens, Mutagens and Reprotoxic substances (CMRs) at EU Member States level This report is based on a one-off survey carried out late 2007-early 2008 among EU-OSHA's network partners at the request of the European Commission. Rather than presenting an in-depth study of the systems in place for setting occupational exposure limits (OELs) for carcinogenic, mutagenic and reprotoxic substances, this report provides a general overview of the situation in 21 Member States. In recent years, all Member States have made available their...
Site AFSSET en matière de substitution des agents chimiques « cancérogènes-mutagènes mutagènes reprotoxiques »
Destiné à tous les professionnels et acteurs de la prévention qui souhaitent engager une démarche de substitution des substances chimiques cancérogènes, mutagènes ou toxiques pour la reproduction (CMR) dans leur établissement, ce site a pour objectif de faire connaître les actions réalisées, les travaux en cours et l'avancée de la recherche dans le domaine de la substitution. En offrant plusieurs niveaux d'information, il doit permettre d'aider ces différents acteurs à rechercher des solutions...

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