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Occupational use of high-level disinfectants and fecundity among nurses
Objective: This study aimed to examine the relationship between occupational use of high-level disinfectants (HLD) and fecundity among female nurses. Methods: Women currently employed outside the home and trying to get pregnant (N=1739) in the Nurses' Health Study 3 cohort (2010–2014) were included in this analysis. Occupational exposure to HLD used to disinfect medical instruments and use of protective equipment (PE) was self-reported on the baseline questionnaire. Every six months thereafter women reported the duration of their ongoing pregnancy attempt. Multivariable accelerated failure...
The Effects of Occupational Exposure of Carbon Disulfide on Sexual Hormones and Semen Quality of Male Workers From a Chemical Fiber Factory
Objective: This study is aimed to analyze the relationship between occupational CS2 exposure and reproductive impairments. Methods: Seventy-six CS2-exposed (9.73?±?2.76?mg/m3) male workers and 94 unexposed workers were selected for study. Worker demographics were assessed with a customized questionnaire. Sexual hormones and sperm-related parameters were measured by biochemical or morphological analysis. Results: The CS2-exposed workers had significantly higher serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and lower levels of testosterone (T). Significant...
Prostate cancer risk among French farmers in the AGRICAN cohort
Objectives: Prostate cancer is one of the most frequent cancers among men worldwide. Its etiology is largely unknown, but an increased risk has been repeatedly observed among farmers. Our aim was to identify occupational risk factors for prostate cancer among farmers in the prospective cohort study AGRICAN. Methods: Data on lifetime agricultural exposures (type of crops, livestock and tasks including pesticide use, re-entry and harvesting) were collected from the enrolment questionnaire. During the period from enrolment (2005–2007) to 31 December 2009, 1672 incident prostate cancers were...
Miscarriage Among Flight Attendants
Background: Cosmic radiation and circadian disruption are potential reproductive hazards for flight attendants. Methods: Flight attendants from 3 US airlines in 3 cities were interviewed for pregnancy histories and lifestyle, medical, and occupational covariates. We assessed cosmic radiation and circadian disruption from company records of 2 million individual flights. Using Cox regression models, we compared respondents (1) by levels of flight exposures and (2) to teachers from the same cities, to evaluate whether these exposures were associated with miscarriage. Results: Of 2654 women interviewed...
Reproductive Health Risks Associated With Occupational Exposures to Antineoplastic Drugs in Health Care Settings
A Review of the Evidence Objectives: Antineoplastic drugs are known reproductive and developmental toxicants. Our objective was to review the existing literature of reproductive health risks to workers who handle antineoplastic drugs. Methods: A structured literature review of 18 peer-reviewed, English language publications of occupational exposure and reproductive outcomes was performed. Results: Although effect sizes varied with study size and population, occupational exposure to antineoplastic drugs seems to raise the risk of both congenital malformations and miscarriage. Studies of infertility...
Two reproduction toxicity evaluations – Chloramphenicol and indium and its compounds
The Health Council of the Netherlands has reviewed chloramphenicol and indium compounds. Indium is used in bearings for cars and aircrafts, in solders and low-melting alloys, and in nuclear reactor control rods. Indium and its compounds, including indium antimonide (InSb), indium arsenide (InAs), and indium phosphide (InP), find application in semiconductor devices, transistors, and transistor materials. Indium oxide is used for colouring glass. Indium sulphate is used in electroplating, and radioisotopes of indium and indium compounds (including indium trichloride) are employed in the treatment...

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