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Occupational Exposure to Aluminum and Alzheimer Disease
A Meta-Analysis Objective: We conducted a meta-analysis to systematically quantify the association between occupational exposure to aluminum and risk of Alzheimer disease (AD). Methods: Electronic database searches were conducted up to March 2015 for controlled studies. Study quality was assessed using the Newcastle-Ottawa Scale. Results: Three retrospective case-control studies, involving 1056 participants, met the criteria for inclusion. All studies used surrogate informants to ascertain exposure. Occupational aluminum exposure was not associated with AD (odds ratio, 1.00; 95% confidence interval...
The Relationship Between Cognitive Impairment and Global DNA Methylation Decrease Among Aluminum Potroom Workers
Objective: To investigate the relationship between cognitive impairment and global DNA methylation in aluminum (Al) potroom workers. Methods: A total of 366 Al-exposed workers were investigated, and their cognitive functions were assessed with the Mini-Mental State Examination (MMSE). Aluminum in serum was quantified using graphite furnace atomic absorption spectrometry. Global DNA methylation was analyzed in whole blood using an enzyme-linked immunosorbent assay–like reaction. Results: Mini-Mental State Examination scores and global DNA methylation decreased with the increase of serum Al...
Time may not fully attenuate solvent-associated cognitive deficits in highly exposed workers
OBJECTIVE: To test the effects of lifetime occupational solvent exposure, as measured by dose and timing, on performance on multiple cognitive tests among retired French utility workers. METHODS: A total of 2,143 retirees in the GAZEL cohort underwent cognitive testing in 2010. Lifetime exposure to chlorinated solvents, petroleum solvents, and benzene was assessed using a job exposure matrix. We modeled effects of lifetime solvent dose, timing of last exposure, and a combination of these metrics on risk for cognitive impairment. RESULTS: Thirty-three percent of participants were exposed to chlorinated...
Cognitive Disorders and Tau-Protein Expression Among Retired Aluminum Smelting Workers
Objectives: To analyze cognitive functions and tau-protein expression in peripheral blood lymphocytes of retired aluminum (Al)-exposed workers. Methods: A total of 66 retired Al potroom workers and 70 unexposed controls were investigated. The cognitive functions were assessed with the Mini-Mental State Examination. The tau-protein expression in peripheral blood lymphocyte was analyzed with Western blot. Results: The cognitive functions of the exposed group were significantly decreased. Twelve mild cognitive impairment cases in the exposed group and four mild cognitive impairment cases in the control...
Neurobehavioral performance among agricultural workers and pesticide applicators
A meta-analytic study Chronic low level exposure of agricultural workers and applicators to pesticides has been found to be associated with different degrees of decrement in cognitive and psychomotor functions. The goal of this study was to use meta-analysis to (1) identify and quantify neurobehavioral deficits among agricultural workers and pesticide applicators, and (2) analyse the potential confounders or moderators of these neurobehavioral deficits. Seventeen studies, reporting on 21 independent cohort groups, were included in the meta-analysis. These studies involved 16 neuropsychological...

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