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Rhinite et asthme dans l'industrie pharmaceutique
L'industrie pharmaceutique en France produit chaque année près de 2 800 substances, présentes dans 11 000 spécialités. Parmi celles-ci, les antibiotiques, les enzymes et d'autres substances végétales comme les gommes sont à l'origine de l'essentiel des cas de rhinite ou d'asthme professionnel (AP) rapportés dans la littérature. Toutefois, les données épidémiologiques sont peu nombreuses et la prévalence des cas apparaît comme faible au regard du nombre de substances mises...
Thresholds in chemical respiratory sensitisation
There is a continuing interest in determining whether it is possible to identify thresholds for chemical allergy. Here allergic sensitisation of the respiratory tract by chemicals is considered in this context. This is an important occupational health problem, being associated with rhinitis and asthma, and in addition provides toxicologists and risk assessors with a number of challenges. In common with all forms of allergic disease chemical respiratory allergy develops in two phases. In the first (induction) phase exposure to a chemical allergen (by an appropriate route of exposure) causes immunological...
Occupational rhinitis and asthma due to EDTA-containing detergents or disinfectants
Background: Detergents and disinfectants are an emerging cause of work-related rhinitis and asthma. These products may contain ethylenediamine tetraacetic acid (EDTA). The authors report 10 cases of EDTA-related asthma and/or rhinitis. Methods: Review of the medical charts of patients who presented with work-related rhinitis (alone or with asthma), with a history of exposure to aerosols of EDTA-containing products and who underwent a nasal provocation test (NPT) with tetrasodium EDTA (1–4%) in our occupational health unit. Results: Twenty-eight patients underwent a NPT with EDTA, which was...

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