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Exposure-response relationships for silicosis and its progression in industrial sand workers
Objectives: This study aimed to characterize the relationship between radiographic silicosis and exposure to respirable quartz and determine how exposure affects disease progression. Methods: Surveillance chest radiographs from a cohort of 1902 workers were examined to identify 67 cases of radiographic silicosis and 167 matched controls. Exposures were estimated by linking work histories to a job exposure matrix (JEM) based on samples collected by the participating companies and historical estimates. Conditional logistic regression was used to examine exposure-response relationships. Sequential...
Assessment of nanofibre dustiness by means of vibro-fluidization
Dustiness testing probes for the propensity of a powdery material to release dust particles following agitation. For high aspect-ratio materials like nanotubes, the most important dust fraction is that of potentially carcinogenic fibres(WHO-fibres).Wedeveloped the fluidizer particularly for fibres thatmakes use of vibro-fluidization in order to effectively disentangle single fibres and agglomerates of multi-walled carbon nanotube powders. Counting rules for morphological characterization of collected particles by means of electron microscopywere established, allowing quantifying the WHO-fibre fraction...
ASTM D6877 - Standard Test Method for Monitoring Diesel Particulate Exhaust in the Workplace
This test method covers determination of organic and elemental carbon (OC and EC) in the particulate fraction of diesel engine exhaust, hereafter referred to as diesel particulate matter (DPM). Samples of workplace atmospheres are collected on quartz-fiber filters. The method also is suitable for other types of carbonaceous aerosols and has been widely applied to environmental monitoring. It is not appropriate for sampling volatile or semi-volatile components. These components require sorbents for efficient collection. Source: https://www.astm.org/Standards/D6877.htm
A Review of Workplace Risk Management Measures for Nanomaterials to Mitigate Inhalation and Dermal Exposure
This review describes an evaluation of the effectiveness of Risk Management Measures (RMM) for nanomaterials in the workplace. Our aim was to review the effectiveness of workplace RMM for nanomaterials and to determine whether established effectiveness values of conventional chemical substances applied for modelling purposes should be adopted or revised based on available evidence. A literature review was conducted to collate nano-specific data on workplace RMM. Besides the quantitative efficacy values, the library was populated with important covariables such as the study design, measurement type...
NF EN 16897 - Exposition sur les lieux de travail
Caractérisation des aérosols ultrafins/nanoaérosols - Détermination de la concentration en nombre à l'aide de compteurs de particules à condensation La présente Norme européenne fournit des lignes directrices sur le mesurage de la fraction particulaire fine de l'aérosol, notamment pour la détermination de la concentration en nombre des aérosols ultrafins et des nanoaérosols sur les lieux de travail à l'aide de compteurs de particules à condensation (CPC). Source: https://www.boutique.afnor...
Workplace exposure and release of ultrafine particles during atmospheric plasma spraying in the ceramic industry
Atmospheric plasma spraying (APS) is a frequently used technique to produce enhanced-property coatings for different materials in the ceramic industry. This work aimed to characterise and quantify the impact of APS on workplace exposure to airborne particles, with a focus on ultrafine particles (UFPs, < 100 nm) and nanoparticles (< 50 nm). Particle number, mass concentrations, alveolar lung deposited surface area concentration, and size distributions, in the range 10 nm–20 μm were simultaneously monitored at the emission source, in the potential worker breathing zone, and in outdoor...
Workplace Measurements of Ultrafine Particles
A Literature Review Workers are exposed to ultrafine particles (UFP) in a number of occupations. In order to summarize the current knowledge regarding occupational exposure to UFP (excluding engineered nanoparticles), we gathered information on UFP concentrations from published research articles. The aim of our study was to create a basis for future epidemiological studies that treat UFP as an exposure factor. The literature search found 72 publications regarding UFP measurements in work environments. These articles covered 314 measurement results and tabled concentrations. Mean concentrations...
Aérosols semi-volatils
De l'identification au prélèvement Des études récentes concernant les aérosols semi-volatils ont révélé des interactions entre les particules et les vapeurs. Encore faut-il être capable d'identifier le caractère semi-volatil d'une substance pour développer une méthode de prélèvement et d'analyse prenant en compte les deux phases, particulaire et vapeur. Cet article a pour but de donner une définition adaptée de ce qu'est un aérosol semi-volatil et d'appliquer...
IARC Monographs Volume 111: Some Nanomaterials and Some Fibres
This volume of the IARC Monographs contains evaluations of the carcinogenic hazard to humans of fluoro-edenite fibrous amphibole, silicon carbide fibres and whiskers, and carbon nanotubes. None of these agents had been evaluated previously by the Working Group. Source: http://monographs.iarc.fr/ENG/Monographs/vol111/index.php
Comparison of methods to evaluate the fungal biomass in heating, ventilation, and air-conditioning (HVAC) dust
Heating, ventilation, and air-conditioning (HVAC) systems contain dust that can be contaminated with fungal spores (molds), which may have harmful effects on the respiratory health of the occupants of a building. HVAC cleaning is often based on visual inspection of the quantity of dust, without taking the mold content into account. The purpose of this study is to propose a method to estimate fungal contamination of dust in HVAC systems. Comparisons of different analytical methods were carried out on dust deposited in a controlled-atmosphere exposure chamber. Sixty samples were analyzed using four...
Biomarkers of Human Cardiopulmonary Response After Short-Term Exposures to Medical Laser-Generated Particulate Matter From Simulated Procedures
A Pilot Study Objective: We conducted an exposure chamber study in humans using a simulated clinical procedure lasing porcine tissue to demonstrate evidence of effects of exposure to laser-generated particulate matter (LGPM). Methods: We measured pre- and post-exposure changes in exhaled nitric oxide (eNO), spirometry, heart rate variability (HRV), and blood markers of inflammation in five volunteers. Results: Change in pre- and post-exposure measurements of eNO and spirometry was unremarkable. Neutrophil and lymphocyte counts increased and fibrinogen levels decreased in four of the five subjects...
Captage des poussières de silice sur les chantiers de rabotage routier aux États-Unis
En France, pour diminuer l'exposition à la silice lors des travaux de recyclage routier, il est conseillé d'équiper les raboteuses d'un dispositif de captage des poussières. Aux États-Unis, des mesures ont été réalisées en atelier et sur le terrain sur le sujet depuis 2003 et ont fait l'objet d'une publication (NIOSH 2015-105)2. Une efficacité de captage des poussières supérieure à 90 % est préconisée. Un protocole de vérification de cette efficacité a été...
Inflammatory Markers and Genetic Polymorphisms in Workers Exposed to Flour Dust
Objective: The aim of this study is to evaluate inflammatory markers and pro-inflammatory CD14 and Toll-like Receptor 4 (TLR4) polymorphisms in workers exposed to flour dust. Methods: Polymorphisms in TLR4 and CD14 were identified in our study population of 167 workers that included 63 healthy subjects (HS), 45 atopic subjects (A), and 59 subjects diagnosed clinically with occupational asthma/rhinitis (OAR). Endpoint measures in this study included fractional exhaled nitric oxide and serum concentrations of interleukin IL-6, IL-8, and tumor necrosis factor-alpha (TNF-α). Results: We identified...
Are the Associations of Cardiac Acceleration and Deceleration Capacities With Fine Metal Particulate in Welders Mediated by Inflammation?
Objective: The aim of this study was to investigate whether associations of acceleration capacity (AC) and deceleration capacity (DC) with metal-PM2.5 are mediated by inflammation. Methods: We obtained PM2.5, C-reactive protein, interleukin (IL)-6, 8, and 10, and electrocardiograms to compute AC and DC, from 45 male welders. Mediation analyses were performed using linear mixed models to assess associations between PM2.5 exposure, inflammatory mediator, and AC or DC, controlling for covariates. Results: The proportion of total effect of PM2.5 on AC or DC (indirect effect) mediated through IL-6 on...
Long-Term Metal PM2.5 Exposures Decrease Cardiac Acceleration and Deceleration Capacities in Welders
Objective: The aim of the study was to clarify whether long-term metal particulates affect cardiac acceleration capacity (AC), deceleration capacity (DC), or both. Methods: We calculated chronic exposure index (CEI) for PM2.5 over the work life of 50 boilermakers and obtained their resting AC and DC. Linear regression was used to assess the associations between CEI PM2.5 exposure and each of AC and DC, controlling for age, acute effects of welding exposure, and diurnal variation. Results: Mean (standard deviation) CEI for PM2.5 exposure was 1.6 (2.4)?mg/m3-work years and ranged from 0.001 to 14...
Occupational exposure levels of bioaerosol components are associated with serum levels of the acute phase protein Serum Amyloid A in greenhouse workers
BACKGROUND: Occupational exposure to particles may be associated with increased inflammation of the airways. Animal experiments suggest that inhaled particles also induce a pulmonary acute phase response, leading to systemic circulation of acute phase proteins. Greenhouse workers are exposed to elevated levels of bioaerosols. The objective of this study is to assess whether greenhouse workers personal exposure to bioaerosol components was associated with serum levels of the acute phase proteins Serum Amyloid A (SAA) and C-reactive protein (CRP). METHODS: SAA and CRP levels were determined in serum...
Size-resolved characterization of particles and fibers released during abrasion of fiber-reinforced composite in a workplace influenced by ambient background sources
We demonstrate the use of high- to low-resolution microscopy and particle chemical analysis during normal vacuum and cryo-conditions to identify the nature and relative abundances of process-generated particles and fibers from sanding of a glass and carbon fiber epoxy layer-composite in a workplace influenced by both indoor and ambient background sources. The study suggests that a proper exposure characterization requires multiple techniques covering wide size ranges to reach a conclusion. Besides a rise in number concentration due to release of particles during the sanding, a significant contribution...
Occupational Exposure to Respirable Dust, Respirable Crystalline Silica and Diesel Engine Exhaust Emissions in the London Tunnelling Environment
Personal 8-h shift exposure to respirable dust, diesel engine exhaust emissions (DEEE) (as respirable elemental carbon), and respirable crystalline silica of workers involved in constructing an underground metro railway tunnel was assessed. Black carbon (BC) concentrations were also assessed using a MicroAeth AE51. During sprayed concrete lining (SCL) activities in the tunnel, the geometric mean (GM) respirable dust exposure level was 0.91mg m−3, with the highest exposure measured on a back-up sprayer (3.20mg m−3). The GM respirable crystalline silica concentration for SCL workers was...
[email protected]
Avec [email protected] , l'INRS aide les entreprises à évaluer le niveau d'empoussièrement aux fibres amiante lors de la mise en œuvre de processus sur matériaux amiantés. Évaluer a priori le risque amiante, c'est ce que propose l'outil [email protected] . Disponible en ligne, il permet aux entreprises concernées par ce risque d'évaluer le niveau d'empoussièrement émis par leur processus, selon la catégorie d'activité dans laquelle s'effectuent les opérations (dites sous-section...
Mise au point sur les risques toxiques lors de l’utilisation professionnelle des photocopieurs
Les photocopieurs sont considérés comme des outils essentiels dans les entreprises. De plus en plus de salariés se plaignent auprès de leur service de santé au travail de symptômes qu'ils attribuent à leur exposition au photocopieur. Il s'agit donc de connaître les risques liés à cette exposition. Le fonctionnement d'un photocopieur est basé sur l'électrophotographie, c'est-à-dire le transfert électrostatique de la poudre de toner vers une surface photoconductrice chargée électriquement...
Comparison of Acute Health Effects From Exposures to Diesel and Biodiesel Fuel Emissions
Objective: To investigate the comparative acute health effects associated with exposures to diesel and 75% biodiesel/25% diesel (B75) blend fuel emissions. Methods: We analyzed multiple health endpoints in 48 healthy adults before and after exposures to diesel and B75 emissions in an underground mine setting—lung function, lung and systemic inflammation, novel biomarkers of exposure, and oxidative stress were assessed. Results: B75 reduced respirable diesel particulate matter by 20%. Lung function declined significantly more after exposure to diesel emissions. Lung inflammatory cells along...
Allergies respiratoires professionnelles chez les professionnels du bois
Les professionnels du bois exercent de multiples activités allant de la sylviculture et exploitation forestière à la construction, en passant par le sciage, la manufacture du bois, le travail artisanal sur bois ou encore l'industrie du papier et du carton. Au cours de leur exercice, leurs expositions professionnelles sont multiples et peuvent occasionner des manifestations respiratoires. Les plus fréquentes sont les asthmes et rhinites, déclenchés par les poussières de bois mais aussi par des produits chimiques utilisés lors de la transformation...
Worker exposure and high time-resolution analyses of process-related submicrometre particle concentrations at mixing stations in two paint factories
The paint and coatings industry is known to have significant particulate matter (PM) emissions to the atmosphere. However, exposure levels are not studied in detail especially when considering submicrometre (PM1) and ultrafine particles (particle diameter below 100nm). The evidence is increasing that pulmonary exposures to these size fractions are potentially very harmful. This study investigates particle emissions during powder handling and paint mixing in two paint factories at two mixing stations in each factory. In each case measurements were made simultaneously at the mixing station (near...
Particulate Matter, Endotoxin, and Worker Respiratory Health on Large Californian Dairies
Objective: To assess respiratory exposures and lung function in a cross-sectional study of California dairy workers. Methods: Exposure of 205 dairy and 45 control (vegetable processing) workers to particulate matter and endotoxin was monitored. Pre- and postshift spirometry and interviews were conducted. Results: Geometric mean inhalable and PM2.5 concentrations were 812 and 35.3 μg/m3 versus 481.9 and 19.6 μg/m3, respectively, for dairy and control workers. Endotoxin concentrations were 329 EU/m3 or 1122 pmol/m3 and 13.5 EU/m3 or 110 pmol/m3, respectively, for dairy and control workers....
Testing the near field/far field model performance for prediction of particulate matter emissions in a paint factory
A Near Field/Far Field (NF/FF) model is a well-accepted tool for precautionary exposure assessment but its capability to estimate particulate matter (PM) concentrations is not well studied. The main concern is related to emission source characterization which is not as well defined for PM emitters compared to e.g. for solvents. One way to characterize PM emission source strength is by using the material dustiness index which is scaled to correspond to industrial use by using modifying factors, such as handling energy factors. In this study we investigate how well the NF/FF model predicts PM concentration...
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