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IARC Monographs Volume 112: Some Organophosphate Insecticides and Herbicides
This volume of the IARC Monographs provides evaluations of the carcinogenicity of some organophosphate insecticides and herbicides, including diazinon, glyphosate, malathion, parathion, and tetrachlorvinphos. Diazinon acts on a wide range of insects on crops, gardens, livestock, and pets, but most uses have been restricted in the USA, Canada, and the European Union since the 1980s. Glyphosate is the most heavily used agricultural and residential herbicide in the world, and has been detected in soil, air, surface water, and groundwater, as well as in food. Malathion is one of the oldest and most...
Organophosphate Pesticide Urinary Metabolites Among Latino Immigrants
North Carolina Farmworkers and Non-farmworkers Compared Background: This analysis documents detections and concentrations of the six dialkylphosphate (DAP) urinary metabolite of organophosphorus (OP) pesticides among North Carolina Latino migrant farmworkers, with comparison to non-farmworker Latino immigrants. Methods: Participants provided up to four urine samples during the 2012 and 2013 agricultural seasons. Composite urine samples for each year were analyzed. Results: DAP urinary metabolite detections were similar in farmworkers and non-farmworker; for example, for 2012, 75.4% of farmworkers...
IARC evaluation of five organophosphate pesticides
A Working Group of 17 experts from 11 countries met at the International Agency for Research on Cancer (IARC), the specialized cancer agency of the World Health Organization on 3-10 March 2015 to review the available published scientific evidence and evaluate the carcinogenicity of five organophosphate insecticides and herbicides: diazinon, glyphosate, malathion, parathion, and tetrachlorvinphos. A summary of the final evaluations together with a short rationale have now been published online in The Lancet Oncology , and the detailed assessments will be published as Volume 112 of the IARC Monographs...
Peripheral Nervous System Function and Organophosphate Pesticide Use among Licensed Pesticide Applicators in the Agricultural Health Study
Background: Evidence is limited that long-term human exposure to organophosphate (OP) pesticides, without poisoning, is associated with adverse peripheral nervous system (PNS) function. Objective: To investigate associations between OP pesticide use and PNS function, we administered PNS tests to 701 male pesticide applicators in the Agricultural Health Study (AHS). Methods: Participants completed a neurological physical examination (NPx), electrophysiological tests, and tests of hand strength, sway speed and vibrotactile threshold. Self-reported information on lifetime use of 16 OP pesticides was...

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