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Neurotoxicity associated with exposure to 1-bromopropane in golf-club cleansing workers
BACKGROUND: 1-Bromopropane (1-BP) is an alternative to ozone-depleting solvent that is used in degreasing, dry cleaning, spray adhesives, and aerosol solvents. Occupational exposure to 1-BP is associated with adverse peripheral sensory, motor, and central nervous system (CNS) effects. We report our Health Hazard and Medical Evaluation of 6 patients with neurotoxicity associated with occupational exposure to 1-BP. Case series and environmental evaluation. Six workers, 1 male and 5 female, were exposed to high ambient 1-BP concentrations while employed in a golf club cleaning factory. 1-BP was identified...
How Does an Occupational Neurologist Assess Welders and Steelworkers for a Manganese-Induced Movement Disorder?
Part II, will present a synopsis of the evaluation including blood and urine manganese and results from one magnetic resonance image and discuss and analyze the results. Limitations and conclusions will be presented. Part I, from an earlier JOEM issue, focused on the historical background and literature supporting parkinsonism and manganese exposure, both from mining and welding. Differential diagnosis, including radiological assessment and methods were discussed. Source : Rutchik, Jonathan S., Zheng, Wei, Jiang, Yueming, Mo, Xuean, How Does an Occupational Neurologist Assess Welders and Steelworkers...
Filling the Knowledge Gaps for Safe Nanotechnology in the Workplace
A Progress Report from the NIOSH Nanotechnology Research Center, 2004–2011. This 2012 update presents the program accomplishments of the NTRC from its inception in 2004 through 2011. It includes an analysis of the progress made toward accomplishing the goals and objectives of the NIOSH Strategic Plan for Nanotechnology Research and toward addressing the goals and research needs identified in the U.S. National Nanotechnology Initiative (NNI) Environmental, Health, and Safety (EHS) research strategy. Source : http://osha.europa.eu/en/news/int-filling-the-knowledge-gaps-for-safe-nanotechnology...
Four types of inorganic nanoparticles stimulate the inflammatory reaction in brain microglia and damage neurons in vitro
Once nanoparticles enter the central nervous system (CNS), they immediately encounter a complex environment of resident microglial immune cell and neurons. In the present study, NPs of 20–60 nm in diameter (SiO2-NPs, TiO2-NPs, HAP-NPs and Fe3O4-NPs) were evaluated for their ability to induce microglia-mediated neurodegeneration. The microglia were directly exposed to NPs. The results showed that both TiO2-NPs and HAP-NPs induced significant iNOS expression, resulting in NO release from the microglia. The expression levels of MCP-1 and MIP-1α were also upregulated. These activation effects...
Neurotoxic exposures and effects: Gender and sex matter! Hänninen Lecture 2011
Donna Mergler, cofondatrice du CINBIOSE, a écrit un article portant sur l'importance du genre et du sexe dans les recherches en neurotoxicologie de l'environnement et du travail. Trop peu de recherches en tiennent compte et ne différencient pas clairement le genre et le sexe. C'est pourquoi l'auteure souligne que c'est un impératif d'en tenir compte! Source : Mergler, D. Neurotoxic exposures and effects: Gender and sex matter! Ha¨nninen Lecture 2011. Neurotoxicology. 2012. http://www.cinbiose.uqam.ca/upload/files/Mergler_2012_Neurotox_gender__sex...
Researchers: Welders May Be at Increased Risk for Brain Damage
New research suggests that workers exposed to welding fumes may be at risk for developing brain damage in an area of the brain also affected in Parkinson's disease. Fumes produced by welding contain manganese, a chemical element that, even at low levels, has been linked to neurologic problems including Parkinson's disease-like symptoms. Source : http://ehstoday.com/health/news/welders-increased-risk-brain-damage-0407/
Nanotechnologies - neurotoxic effects of nanomaterials
There are certain concerns regarding the safety for the environment and human health from the use of engineered nanoparticles (ENPs), which leads to unintended exposures, in contrast to the use of ENPs for medical purposes. Animal experiments have shown that investigated ENPs (metallic nanoparticles, quantum dots, carbon nanotubes) can translocate to the brain from different entry points (skin, blood, respiratory pathways). Source: http://osha.europa.eu/en/news/nanotechnologies-neurotoxic-effects-of-nanomaterials
Potential developmental neurotoxicity of pesticides used in Europe
Pesticides used in agriculture are designed to protect crops against unwanted species, such as weeds, insects, and fungus. Many compounds target the nervous system of insect pests. Because of the similarity in brain biochemistry, such pesticides may also be neurotoxic to humans. Concerns have been raised that the developing brain may be particularly vulnerable to adverse effects of neurotoxic pesticides. Current requirements for safety testing do not include developmental neurotoxicity. We therefore undertook a systematic evaluation of published evidence on neurotoxicity of pesticides in current...

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