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Surveillance biologique de l’exposition professionnelle (SBEP) aux médicaments anticancéreux au sein d’un hôpital Mauritanien
Contexte: En Mauritanie, l'activité du Centre National d'Oncologie (CNO) n'a cessé de croître, entraînant une augmentation de la manipulation de médicaments anticancéreux (MAC). Dans ce contexte, la contamination des professionnels aux MAC a été évaluée. Méthodes: L'intervention s'est déroulée en 2015, dans 2 services de soins, et a évalué des infirmiers (IDE) préparant et administrant des MAC et des agents en charge de l'hygiène (AH). Chaque participant a...
Urinary Bisphenol A (BPA) Concentrations among Workers in Industries that Manufacture and Use BPA in the USA
Background: Bisphenol A (BPA) toxicity and exposure risk to humans has been the subject of considerable scientific debate; however, published occupational exposure data for BPA are limited. Methods: In 2013-2014, 77 workers at six US companies making BPA, BPA-based resins, or BPA-filled wax provided seven urine samples over two consecutive work days (151 worker-days, 525 samples). Participant information included industry, job, tasks, personal protective equipment used, hygiene behaviors, and canned food/beverage consumption. Total (free plus conjugated) BPA, quantified in urine by mass spectrometry...
Relationship Between Urinary Nickel and Methylation of p15, p16 in Workers Exposed to Nickel
Objective: The purpose of this study was to investigate the relationship between urinary nickel and methylation of p15, p16 in workers exposed to nickel. Methods: In this study, 165 nickel-exposed workers and 67 workers without exposure were recruited. The levels of urinary nickel were analyzed using dimethylglyoxime spectrophotometric method. Methylation–specific polymerase chain reaction was used to detect the methylation of p15 and p16. Results: The median concentration of urinary nickel in the exposed group (4.58 μg/L) was significantly higher than that in the control group (1.78 μg...
Surveillance biologique de l'exposition professionnelle
Quel mode de correction urinaire choisir lors de prélèvements ponctuels? L'utilisation de prélèvements ponctuels pour la mesure de la concentration urinaire de biomarqueurs est une pratique courante dans le cadre des activités de surveillance biologique de l'exposition professionnelle. Afin de tenir compte du degré de dilution des urines, les concentrations urinaires mesurées dans ce type de prélèvements sont généralement corrigées en fonction de la créatinine ou de la densité spécifique...
Urinary S-phenylmercapturic Acid as a Key Biomarker for Measuring Occupational Exposure to Low Concentrations of Benzene in Chinese Workers
A Pilot Study Objective: This study analyzed the level of urinary S-phenylmercapturic acid (U-SPMA) for low benzene exposure in a group of Chinese shoe-making workers. Methods: Urinary samples from 55 workers exposed to benzene at levels lower than 10 parts per million (ppm) were collected at postshift. U-SPMA level was determined using high-performance liquid chromatography/mass spectrography (HPLC/MS) method. Results: Good linearity of U-SPMA was observed within the range from 10 to 320 μg/L (r = 0.9994). Concentration of airborne benzene ranged from 0.71 to 32.17 mg/m3, and three segments...

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