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Occupational exposure to benzene, toluene, xylene and styrene and risk of prostate cancer in a population-based study
Objectives: While several monocyclic aromatic hydrocarbons are classified as definite or possible carcinogens to humans, little data exist on their role in prostate cancer (PCa). We examined occupational exposure to benzene, toluene, xylene (BTX) and styrene and PCa risk in a population-based case–control study in Montreal, Canada. Methods: Cases aged ≤75 years diagnosed with PCa in 2005–2009 (n=1920) and population controls frequency-matched on age (n=1989) provided detailed work histories. Experts evaluated the certainty, frequency and concentration of exposure to monocyclic aromatic...
Case-control investigation of occupational exposure to chlorinated solvents and non-Hodgkin’s lymphoma
Objectives: Although many studies have investigated the association between trichloroethylene (TCE) exposure and non-Hodgkin's lymphoma (NHL), less is known about other chlorinated solvents. We extended our previous analysis of occupational TCE exposure in a multicentre population-based case-control study of NHL to investigate associations with five additional chlorinated solvents: 1,1,1,-trichloroethane, carbon tetrachloride, chloroform, methylene chloride and perchloroethylene. Methods: Cases (n=1189) and controls (n=982) provided detailed information on their occupational histories and workplace...
Kidney Cancer Risk in Oil Refining in Finland
A Nested Case-Referent Study Objective: The purpose of this study was to assess whether occupational exposure to hydrocarbons in the oil-refining activity increases the risk of kidney cancer. Methods: This case-referent study was nested within the cohort of employees in the oil refinery industry in Finland in 1967 to 1982 (n = 9454). The final data included 30 cases of kidney cancer and 81 age- and sex-matched referents. Results: There was a threefold increase in the kidney cancer risk for exposure to hydrocarbons in crude oil (odds ratio, 3.1; confidence interval, 1.1 to 8.9; 11 exposed cases...
Exposure to chlorinated solvents and lung cancer
Results of the ICARE study Objective: To investigate the role of occupational exposure to chlorinated solvents in lung cancer aetiology. Methods: ICARE (Investigation of occupational and environmental CAuses of REspiratory cancers) is a French, multicentre, population-based, case–control study. Information on the lifelong work history of 2926 cases and 3555 controls was collected using standardised questionnaires. Occupational exposures were assessed using job-exposure matrices for five chlorinated solvents. Solvents were studied separately and in combinations. ORs were computed using unconditional...
L'Anses publie ses recommandations en vue de réduire l'exposition à cinq substances reprotoxiques et/ou perturbatrices endocriniennes
L'Anses a été saisie en 2009 par le ministère chargé de la santé afin d'identifier et de caractériser des situations d'exposition potentiellement à risque pour la santé liées à l'utilisation de produits de consommation courante et/ou d'articles contenant certaines substances chimiques classées reprotoxiques de catégorie 2 (selon le règlement européen dit CLP) ou considérées comme perturbatrices endocriniennes. L'Anses publie aujourd'hui plusieurs rapports d'expertise...
Occupational exposure to solvents and acute myeloid leukemia
A population-based, case–control study in four Nordic countries Objective: The aim of the current study was to assess the relation between occupational exposure to solvents and the risk of acute myeloid leukemia (AML). Methods: Altogether, this study comprises 15 332 incident cases of AML diagnosed in Finland, Norway, Sweden and Iceland from 1961–2005 and 76 660 controls matched by year of birth, sex, and country. Occupational records were linked with Nordic Occupational Cancer Study job exposure matrix (JEM) to estimate quantitative values for 26 occupational exposure factors. Hazard...

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