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Evaluation of Systemic Health Effects Following Dermal Exposure to Chemicals - TR 119
Risk assessment of chemicals, including the REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) legislation, also cover assessments of dermal risk arising from exposure to chemicals. The European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) has produced this guidance consisting of a tiered approach for the risk assessment of dermal exposure to a chemical. The process developed by the Task Force consists of three linked decision trees, i.e.: Derivation of a health-based reference value; Initial risk characterisation; Refined risk characterisation. It is...
Take a postage stamp. Stick it to your arm. You've just covered 16 million cells, 55 hairs, 8 meters of nerves, 17,000 nerve endings, 5 meters of blood vessels, 500 sweat glands, and 83 oil glands. You've also just wasted 44 cents. Your skin is marvelously complex. It is your largest organ, accounting for 10% of your body's mass. It is also the site of 15 to 20 percent of all reported work-related illnesses according to the US Bureau of Labor Statistics. Skin can suffer direct, sensitizing, or systemic effects when exposed to hazardous chemicals. Direct exposure can corrode, irritate...

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