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Current state of knowledge on the health effects of engineered nanomaterials in workers
A systematic review of human studies and epidemiological investigations Objectives: The widespread application of nano-enabled products and the increasing likelihood for workplace exposures make understanding engineered nanomaterial (ENM) effects in exposed workers a public and occupational health priority. The aim of this study was to report on the current state of knowledge on possible adverse effects induced by ENM in humans to determine the toxicological profile of each type of ENM and potential biomarkers for early detection of such effects in workers. Methods: A systematic review of human...
Investigation d’un syndrome collectif inexpliqué parmi le personnel d’un centre de recherche dans l’Hérault
En février 2017, Santé publique France (région Occitanie) est contactée pour un signalement concernant un problème d'odeur dans un centre de recherche. Depuis le mois d'avril 2016, des épisodes d'odeurs (décrites comme des odeurs de solvants ou d'éther) incommodent fortement les personnels travaillant dans le bâtiment de l'animalerie. La plupart de ces personnels décrit des symptômes tels que maux de tête, nausées, vomissement, irritations des voies aériennes… Une réunion...
Agents fibrogènes et cancérogènes dans les mines d’or et de fer du Québec - Étude exploratoire
De récentes études ont mis en évidence que les travailleurs des mines d’or du Dakota et des mines de fer du Minnesota sont exposés à des particules minérales allongées (PMA). En particulier, les mineurs du Minnesota présentent un risque plus élevé de décès par cancer du poumon, par mésothéliome et par maladies cardiaques que la population générale. Comme l’intérêt renouvelé pour l’exploration de nouveaux gisements d’or et de fer dans le Nord...
Cancer de la vessie et expositions professionnelles aux fluides de coupe
Étude épidémiologique parmi les travailleurs de la sidérurgie en France L'objectif de cette étude est de rechercher s'il existe un risque de cancer de la vessie associé à des expositions professionnelles à des brouillards d'huiles, issus de l'utilisation d'huiles entières ou de fluides aqueux. Une étude cas-témoins a été mise en place au sein d'une cohorte de 22 795 travailleurs de la sidérurgie du Nord - Pas-de-Calais. Les cas de cancer de vessie ont été diagnostiqués...
Association of Parkinson’s disease with industry sectors
A French nationwide incidence study In order to identify working environments at risk for Parkinson's disease (PD), we investigated the relation between the importance of industry sectors, used as a surrogate for occupational exposures, and PD incidence in French cantons. The number of incident PD cases (2010–2014) in 3689 cantons of metropolitan France was determined using drug claims from French National Health Insurance databases. The proportions of workers in 38 industry sectors in 2006 were calculated for each canton. Associations between the proportions of workers in industry sectors...
Firefighters and cancer: the epidemiological evidence
It is recognised that firefighters can be exposed to many different harmful substances. In 2007 the International Agency for Research on Cancer convened a working group to assess the carcinogenicity of a variety of occupations, increased rates of testicular, prostate and non-Hodgkin's lymphoma were identified for firefighting. This report examines the research published since an IOM review for the UK Industrial Injuries Advisory Council, by carrying out a systematic review and meta-analyses of the epidemiological evidence for specific cancers in firefighters. In total 304 publications were...
Diesel Emissions and Lung Cancer
An Evaluation of Recent Epidemiological Evidence for Quantitative Risk Assessment This report contains the intensive review and analysis of the newest studies of mine and truck workers exposed to older diesel engine exhaust conducted by an Expert Panel appointed by the HEI Board of Directors. In its report, HEI's Diesel Epidemiology Panel concluded that the studies are well prepared and are useful for applying the data to calculate the cancer risk due to exposure to diesel exhaust. The Panel noted, however, that efforts to apply these studies to estimate human risk at today's ambient levels...
Occupation and environmental heat-associated deaths in Maricopa County, Arizona: a case-control study
Background Prior research shows that work in agriculture and construction/extraction occupations increases the risk of environmental heat-associated death. Purpose To assess the risk of environmental heat-associated death by occupation. Methods This was a case-control study. Cases were heat-caused and heat-related deaths occurring from May-October during the period 2002–2009 in Maricopa County, Arizona. Controls were selected at random from non-heat-associated deaths during the same period in Maricopa County. Information on occupation, age, sex, and race-ethnicity was obtained from death...
Association between heat stress and occupational injury among Thai workers
Global warming will increase heat stress at home and at work. Few studies have addressed the health consequences in tropical low and middle income settings such as Thailand. We report on the association between heat stress and workplace injury among workers enrolled in the large national Thai Cohort Study in 2005 (N=58,495). We used logistic regression to relate heat stress and occupational injury separately for males and females, adjusting for covariate effects of age, income, education, alcohol, smoking, Body Mass Index, job location, job type, sleeping hours, existing illness, and having to...
A Road Map Toward a Globally Harmonized Approach for Occupational Health Surveillance and Epidemiology in Nanomaterial Workers
Objective: Few epidemiological studies have addressed the health of workers exposed to novel manufactured nanomaterials. The small current workforce will necessitate pooling international cohorts. Method : A road map was defined for a globally harmonized framework for the careful choice of materials, exposure characterization, identification of study populations, definition of health endpoints, evaluation of appropriateness of study designs, data collection and analysis, and interpretation of the results.Results: We propose a road map to reach global consensus on these issues. The proposed strategy...
Mesothelioma mortality in Great Britain: The revised risk and two-stage clonal expansion models
Asbestos is a known carcinogen that is the cause of the majority of mesothelioma cases worldwide. Various models have been used to describe the increase and likely future pattern of mesothelioma rates seen in many western countries - a legacy of past heavy industrial asbestos use. Following on from previous work (Tan and Warren, 2009), we analysed female mesothelioma mortality using the same risk model that was assumed for males. We also analysed mesothelioma mortality in males in Great Britain using two alternative risk models; the first is based on asbestos import data where the population is...
Revue des études épidémiologiques sur les maladies reliées à l'exposition à l'amiante ajouté aux enrobés bitumineux
L'Institut national de santé publique du Québec a reçu du ministère de la Santé et des Services sociaux le mandat de rédiger un avis sanitaire portant sur les enrobés bitumineux contenant de l'amiante chrysotile. Pour aider à préparer cet avis, le présent document résume la littérature épidémiologique publiée sur les maladies reliées à l'exposition à l'amiante survenues chez les travailleurs exposés à l'amiante ajouté au bitume pour...
The burden of occupational cancer in Great Britain
The aim of this project was to produce an updated estimate of the current burden of occupational cancer specifically for Great Britain. The primary measure of the burden of cancer used in this project was the attributable fraction (AF) i.e. the proportion of cases that would not have occurred in the absence of exposure; this was then used to estimate the attributable numbers. This involved obtaining data on the risk of the disease due to the exposure of interest, taking into account confounding factors and overlapping exposures, and the proportion of the target population exposed over the period...
Projection of mesothelioma mortality in Great Britain
There has been an increase in mesothelioma mortality in Great Britain, with 1705 deaths recorded in 2006. In 2005, a statistical model was developed based on a simple birth-cohort model, which assumes that the risk of mesothelioma depends on age and years of exposure and that an individual's asbestos exposure depends on the year of exposure. An optimisation technique was used to fit the model and a profile of the population exposure was estimated. Projections of the future burden of mesothelioma mortality were calculated, however statistical uncertainties in the formulation of the model could...

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