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Occupational exposures to solvents and metals are associated with fixed airflow obstruction
Our study is the first to investigate the associations between exposures to solvents and metals using lifetime work history calendars and fixed airflow obstruction (AO). We have shown that increasing cumulative exposure-unit years to chlorinated solvents is associated with fixed AO. We found that women were at increased risk of fixed AO with increasing cumulative exposed-unit-years to chlorinated solvents but not men. Source: Alif SM, Dharmage SC, Benke G, Dennekamp M, Burgess JL, Perret, Lodge CJ, Morrison S, Johns DP?, Giles GG, Gurrin LC, Thomas PS, Hopper JL, Wood-Baker R, Thompson BR, Feather...
Are the Associations of Cardiac Acceleration and Deceleration Capacities With Fine Metal Particulate in Welders Mediated by Inflammation?
Objective: The aim of this study was to investigate whether associations of acceleration capacity (AC) and deceleration capacity (DC) with metal-PM2.5 are mediated by inflammation. Methods: We obtained PM2.5, C-reactive protein, interleukin (IL)-6, 8, and 10, and electrocardiograms to compute AC and DC, from 45 male welders. Mediation analyses were performed using linear mixed models to assess associations between PM2.5 exposure, inflammatory mediator, and AC or DC, controlling for covariates. Results: The proportion of total effect of PM2.5 on AC or DC (indirect effect) mediated through IL-6 on...
Long-Term Metal PM2.5 Exposures Decrease Cardiac Acceleration and Deceleration Capacities in Welders
Objective: The aim of the study was to clarify whether long-term metal particulates affect cardiac acceleration capacity (AC), deceleration capacity (DC), or both. Methods: We calculated chronic exposure index (CEI) for PM2.5 over the work life of 50 boilermakers and obtained their resting AC and DC. Linear regression was used to assess the associations between CEI PM2.5 exposure and each of AC and DC, controlling for age, acute effects of welding exposure, and diurnal variation. Results: Mean (standard deviation) CEI for PM2.5 exposure was 1.6 (2.4)?mg/m3-work years and ranged from 0.001 to 14...
Risk of Pancreatic Cancer in Female Textile Workers in Shanghai, China, Exposed to Metals, Solvents, Chemicals, and Endotoxin
Follow-Up to a Nested Case-Cohort Study Objective: We studied associations between pancreatic cancer and occupational exposures to metals, solvents, chemicals, and endotoxin in a cohort of female textile workers in Shanghai, China. To assess the longer-term influences of these agents on pancreatic cancer we extended follow-up of this previously studied cohort. Methods: We utilized a job exposure matrix to assess occupational exposures for 481 pancreatic cancer cases and a randomly selected sub-cohort of 3191 non-cases. We calculated hazard ratios and 95% confidence intervals using Cox proportional...
The Relationship Between Occupational Metal Exposure and Arterial Compliance
Background: The objective of this study was to evaluate the relationship between cumulative occupational exposure to various metals and arterial compliance in welders. Methods: The observational follow-up study consisted of 25 subjects. Levels of nickel (Ni), lead, cadmium, manganese, and arsenic from toenails were assessed using mass spectrometry. Arterial compliance as reflected by augmentation index (AIx) was measured using SphygmoCor Px Pulse Wave Analysis System. Linear regression models were used to assess the associations. Results: For every 1 unit increase in log-transformed toenail Ni...
Cognitive function among sons of women who worked in dentistry
Objective Exposure to elemental mercury vapor can impair neurological function as it is neurotoxic in doses higher than usually found in dentistry. Little is known about the potential effects of fetal exposure to elemental mercury among offspring of female dental workers. We investigated cognitive function among offspring of women working in dentistry at the time of their pregnancy. Methods We compared results for cognitive function examinations taken by the majority of young men in Sweden at the time of compulsory military enlistment (age 17–18 years). Sons of female dentists (N=365) and...
Cobalt Doped Tungsten Carbide Nanoparticles and Mammalian Cells
To achieve harder metals that don't wear down quickly, manufacturers are considering the use of tungsten-carbide nanoparticles and cobalt, which is thought to increase the strength and durability of the finished product. Unfortunately, as Susanne Bastian et al's article "Toxicity of Tungsten Carbide and Cobalt-Doped Carbide Nanoparticles in Mammalian Cells in Vitro" (Supplemental Material available here), demonstrates, increased exposure to these nanoparticles will, in all likelihood, lead to increased incidences of asthma, other respritory illnesses, and lung cancer among workers...

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