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Survey of guidelines and current practices for safe handling of antineoplastic and other hazardous drugs used in 24 countries
Purpose A survey of guidelines and current practices was conducted to examine the safe handling procedures for antineoplastic and other hazardous drugs that are used in 24 countries including the Americas, Europe, the Mideast, Far East, and Australia. Methods Subject experts were asked to complete a brief survey regarding safe handling guidelines and practices for hazardous drugs in their countries. Questions addressed practices for handling monoclonal antibodies, the use of closed-system transfer devices, medical surveillance practices, and measurements of compliance with existing guidelines....
Soignants et médicaments cytotoxiques
Place de la biométrologie dans la maîtrise des risques dans le temps Les médicaments cytotoxiques utilisés dans les traitements des cancers présentent une toxicité intrinsèque, du fait de leurs propriétés génotoxiques, tératogènes et cancérigènes. Les professionnels de santé pouvant y être exposés, il est essentiel de garantir leur sécurité et de mettre en place des programmes d'évaluation des expositions pour documenter les expositions, juger de l'efficacité...
Prévenir les risques chimiques lors d'une chimiothérapie intrapéritonéale pressurisée par aérosolisation (CIPPA ou PIPAC)
Une équipe de la faculté de médecine de l'Université de la Ruhr, à Bochum en Allemagne, a récemment mis au point une nouvelle technique de chimiothérapie intrapéritonéale : la chimiothérapie intrapéritonéale pressurisée par aérosolisation (CIPPA, PIPAC en anglais). Cette procédure, apparentée à la chimiothérapie hyperthermique intrapéritonéale (CHIP) utilisée depuis plusieurs années, offre de nouvelles perspectives pour la prise en charge...
Adverse effects of pesticides on biochemical and haematological parameters in Tunisian agricultural workers
Biomonitoring of effects in agricultural workers is necessary to assess the individual risk of handling pesticides. In this study, biochemical and haematological parameters were measured to evaluate the effects of exposure to these compounds in agricultural workers. The study was carried out in 110 workers and 97 control subjects. Several haematological and biochemical parameters were analysed. Assessment of haematological parameters revealed that the mean cell volume and haematocrit levels were significantly lower in workers than in controls (P=0.002 and 0.013, respectively), while mean corpuscular...
Reducing Cytotoxic Drug Exposure in Healthcare: Determinants Influencing Cleaning Effectiveness
Many cytotoxic drugs used to treat cancer and other diseases are known to be carcinogenic or mutagenic. Health care workers who handle these drugs may be at risk of developing adverse health effects such as organ toxicities, reproductive problems, tumours, and cancer. Although several guidelines for cytotoxic drug handling exist, studies have shown that contamination can occur even when proper engineering controls are in place. Using laboratory research methods, this project examined the effectiveness of the cleaning agents used to clean surfaces contaminated with the three cytotoxic drugs most...

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