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Description par type de cancer des situations professionnelles à risque : synthèse des données du réseau RNV3P
L'ANSES (Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail) et le RNV3P (Réseau National de Vigilance et de Prévention des Pathologies Professionnelles) mettent en ligne un rapport identifiant les situations professionnelles à risque pour plusieurs types de cancers. Sont abordés les cancers broncho-pulmonaires, les cancers urothéliaux, les hémopathies lymphoïdes matures, les leucémies myéloïdes, le cancer du larynx, le cancer des fosses nasales et des sinus, le cancer...
Sinistralité et repérage des cancers professionnels dans neuf pays européens
EUROGIP publie un nouveau rapport dont les données portent sur l'Allemagne, l'Autriche, la Belgique, le Danemark, la Finlande, la France, l'Italie, la Suède, la Suisse. Les cas (déclarations et reconnaissances) de cancers depuis 2005 sont relativement stables au Danemark, en Belgique, France, Italie et Suède, mais en augmentation en Autriche, Allemagne et Suisse. Pour cette dernière catégorie, les raisons sont diverses, comme l'inscription du cancer de la peau en Allemagne en 2015 sur la liste nationale des MP. Dans tous les pays à...
Agents fibrogènes et cancérogènes dans les mines d’or et de fer du Québec - Étude exploratoire
De récentes études ont mis en évidence que les travailleurs des mines d’or du Dakota et des mines de fer du Minnesota sont exposés à des particules minérales allongées (PMA). En particulier, les mineurs du Minnesota présentent un risque plus élevé de décès par cancer du poumon, par mésothéliome et par maladies cardiaques que la population générale. Comme l’intérêt renouvelé pour l’exploration de nouveaux gisements d’or et de fer dans le Nord...
Cancer de la vessie et expositions professionnelles aux fluides de coupe
Étude épidémiologique parmi les travailleurs de la sidérurgie en France L'objectif de cette étude est de rechercher s'il existe un risque de cancer de la vessie associé à des expositions professionnelles à des brouillards d'huiles, issus de l'utilisation d'huiles entières ou de fluides aqueux. Une étude cas-témoins a été mise en place au sein d'une cohorte de 22 795 travailleurs de la sidérurgie du Nord - Pas-de-Calais. Les cas de cancer de vessie ont été diagnostiqués...
Occupational exposure to benzene, toluene, xylene and styrene and risk of prostate cancer in a population-based study
Objectives: While several monocyclic aromatic hydrocarbons are classified as definite or possible carcinogens to humans, little data exist on their role in prostate cancer (PCa). We examined occupational exposure to benzene, toluene, xylene (BTX) and styrene and PCa risk in a population-based case–control study in Montreal, Canada. Methods: Cases aged ≤75 years diagnosed with PCa in 2005–2009 (n=1920) and population controls frequency-matched on age (n=1989) provided detailed work histories. Experts evaluated the certainty, frequency and concentration of exposure to monocyclic aromatic...
Expositions professionnelles à des agents cancérogènes respiratoires chez les salariés en 2010
Introduction – Les cancers respiratoires sont les plus fréquents des cancers professionnels, mais très peu de données sont disponibles pour quantifier l'exposition professionnelle aux cancérogènes respiratoires. L'objectif de ce travail était d'évaluer en France la proportion de salariés exposés à des agents cancérogènes respiratoires et d'identifier les groupes professionnels les plus exposés, à des fins de prévention. Méthode – À partir des données...
Case-control investigation of occupational exposure to chlorinated solvents and non-Hodgkin’s lymphoma
Objectives: Although many studies have investigated the association between trichloroethylene (TCE) exposure and non-Hodgkin's lymphoma (NHL), less is known about other chlorinated solvents. We extended our previous analysis of occupational TCE exposure in a multicentre population-based case-control study of NHL to investigate associations with five additional chlorinated solvents: 1,1,1,-trichloroethane, carbon tetrachloride, chloroform, methylene chloride and perchloroethylene. Methods: Cases (n=1189) and controls (n=982) provided detailed information on their occupational histories and workplace...
Burden of lung cancer attributable to occupational diesel engine exhaust exposure in Canada
Objective: To estimate the population attributable fraction (PAF) and number of incident and fatal lung cancers in Canada from occupational exposure to diesel engine exhaust (DEE). Methods: DEE exposure prevalence and level estimates were used with Canadian Census and Labour Force Survey data to model the exposed population across the risk exposure period (REP, 1961–2001). Relative risks of lung cancer were calculated based on a meta-regression selected from the literature. PAFs were calculated using Levin's equation and applied to the 2011 lung cancer statistics obtained from the Canadian...
Cas incidents des maladies à déclaration obligatoire reliées à une exposition professionnelle à l’amiante dans le Système MADO-Chimique, Québec, 2006 – 2015
L'analyse des 2 234 cas incidents de maladies à déclaration obligatoire (MADO) reliées à une exposition professionnelle à l'amiante enregistrés dans le système MADO-Chimique entre 2006 et 2015 montre que : 98 % des cas sont des hommes. Chez les femmes, les mésothéliomes sont les maladies reliées à l'exposition à l'amiante les plus fréquentes, alors que chez les hommes ce sont les amiantoses qui prédominent. Près de 60 % des cas d'amiantose, près de 50 % des cas de...
Occupational exposure to organic solvents and risk of male breast cancer
A European multicenter case-control study Objectives: The etiology of male breast cancer (MBC) is largely unknown but a causal role of exposure to organic solvents has been suggested. Previous studies on occupational risk factors of breast cancer were often restricted to women who are frequently exposed to lower levels and at a lower frequency than men. We investigated the association between MBC and occupational exposure to petroleum and oxygenated and chlorinated solvents in a multicenter case–control study of rare cancers in Europe. Methods: The study included 104 MBC cases and 1901 controls...
State of the evidence 2017: an update on the connection between breast cancer and the environment
Singly and in combination, these toxicants may have contributed significantly to the increasing rates of breast cancer observed over the past several decades. Exposures early in development from gestation through adolescence and early adulthood are particularly of concern as they re-shape the program of genetic, epigenetic and physiological processes in the developing mammary system, leading to an increased risk for developing breast cancer. In the 8 years since we last published a comprehensive review of the relevant literature, hundreds of new papers have appeared supporting this link, and in...
Exposition des salariés à de multiples nuisances cancérogènes en 2010
Introduction – Les facteurs professionnels susceptibles d'augmenter les risques de cancer sont généralement étudiés séparément les uns des autres, alors que les expositions aux agents cancérogènes sont souvent multiples. L'objectif de ce travail était de fournir des indicateurs d'exposition des salariés à un ensemble de cancérogènes, chimiques ou non, et d'identifier des groupes de salariés particulièrement exposés à des fins de prévention. Méthode...
Establishing a policy framework for the primary prevention of occupational cancer
A proposal based on a prospective health policy analysis Background: Despite our knowledge of the causes of cancer, millions of workers are involuntarily exposed to a wide range of known and suspected carcinogens in the workplace. To address this issue from a policy perspective, we developed a policy framework based on a prospective health policy analysis. Use of the framework was demonstrated for developing policies to prevent cancers associated with diesel engine exhaust (DEE), asbestos, and shift work, three occupational carcinogens with global reach and large cancer impact. Methods: An environmental...
Lung Cancer Among Firefighters
Smoking-Adjusted Risk Estimates in a Pooled Analysis of Case-Control Studies Objectives: The aim of this study was to explore lung cancer risk among firefighters, with adjustment for smoking. Methods: We used pooled information from the SYNERGY project including 14 case-control studies conducted in Europe, Canada, New Zealand, and China, with lifetime work histories and smoking habits for 14,748 cases of lung cancer and 17,543 controls. We estimated odds ratios by unconditional logistic regression with adjustment for smoking and having ever been employed in a job known to present an excess risk...
Association Between Kidney Cancer and Occupational Exposure to Trichloroethylene
Objective: This study investigates the association between occupational exposure to trichloroethylene (TCE) and kidney cancer, as this correlation has been questioned. Methods: The incidence of cancers was studied in a dynamic cohort of 997 male workers who for many years had been occupationally exposed to TCE. Results: During a 50-year observation period, 13 cases of kidney cancer were observed (7.5 expected) with a standardized incidence ratio of 1.7 and a 95% confidence interval of 1.0 to 3.0. Four other cases, not included in the SIR analysis, were also observed. Long-term TCE exposure was...
Breast cancer incidence among female flight attendants
Exposure–response analyses In a cohort of 6093 female flight attendants, breast cancer incidence was not associated with cumulative exposure to cosmic radiation or two metrics of circadian rhythm disruption. Positive exposure–response relations were observed only in the small subset of the cohort with parity of three or more. Cautious interpretation of the findings in women with high parity is warranted. Source: Pinkerton LE, Hein MJ, Anderson JL, Little MP, Sigurdson AJ, Schubauer-Berigan MK. Scand J Work Environ Health , 2016. http://dx.doi.org/10.5271/sjweh.3586
Occupation and Risk of Bladder Cancer in Nordic Countries
Objective: The purpose of the study was to describe the variation of bladder cancer incidence according to occupational categories in the Nordic countries. Methods: The study cohort comprised 15 million individuals older than 30 years who participated in one or more population censuses in 1960, 1970, 1980/1981, and/or 1990. Standardized incidence ratios (SIRs) were estimated for 53 occupational categories. Results: Significantly increased SIRs were observed among tobacco workers (1.57; 95% confidence interval [CI] 1.24 to 1.96), chimney sweeps (1.48; 95% CI 1.21 to 1.80), waiters (1.43; 95% CI...
Professional Cleaning Activities and Lung Cancer Risk Among Women
Results From the ICARE Study Objectives: Lung cancer risk associated with occupational cleaning activities has been investigated in the population-based case–control study ICARE. Methods: Occupational history was collected by standardized interviews. Jobs were first defined according to the International Standard Classification of Occupations (ISCO) codes and then categorized according to activity sectors. Adjusted odds ratios (ORs) were estimated by unconditional logistic regression, separately for women (619 cases and 760 controls) and men (2265 and 2780). Results: Thirty percent of women...
Evaluation of Acute Nonlymphocytic Leukemia and Its Subtypes With Updated Benzene Exposure and Mortality Estimates
A Lifetable Analysis of the Pliofilm Cohort Objective: US Environmental Protection Agency (EPA) based its benzene carcinogenicity assessment on the Pliofilm cohort. We evaluated associations between benzene exposure and acute nonlymphocytic leukemia (ANLL) and acute myelocytic leukemia (AML) risks using this cohort's updated exposure estimates and mortality data. Methods: We calculated standardized mortality ratios (SMRs) for ANLL/AML using lifetable analyses, with various exposure quantile categories and lag times. Results: Workers in the highest exposure categories had significantly elevated...
Australian Work Exposure Study (AWES) - Carcinogen Exposures Construction Industry
A random, population-based sample of 5528 Australian workers participated in the Australian Work Exposure Study (AWES). Workers answered questions about the tasks they completed and the controls used at work. Based on their responses to those questions, the likelihood of exposure to 38 known or suspected carcinogens was estimated. The AWES focused on the most common tasks performed at work. Workers were not asked directly about their exposures to carcinogens and exposure levels were not measured in the workplace. This report describes the responses provided by 459 AWES participants categorised...
Australian Work Exposures Study (AWES) - Carcinogen Exposures Manufacturing Industry
A random, population-based sample of 5528 Australian workers participated in the Australian Work Exposure Study (AWES). Workers answered questions about the tasks they completed and the controls used at work. Based on their responses to those questions, the likelihood of exposure to 38 known or suspected carcinogens was estimated. The AWES focused on the most common tasks performed at work. Workers were not asked directly about their exposures to carcinogens and exposure levels were not measured in the workplace. This report describes the responses provided by 281 AWES participants categorised...
Australian Work Exposures Study (AWES) - Carcinogen Exposures Agricultural Industry
A random, population-based sample of 5528 Australian workers participated in the Australian Work Exposure Study (AWES). Workers answered questions about the tasks they completed and the controls used at work. Based on their responses to those questions, the likelihood of exposure to 38 known or suspected carcinogens was estimated. The AWES focused on the most common tasks performed at work. Workers were not asked directly about their exposures to carcinogens and exposure levels were not measured in the workplace. This report describes the responses provided by 156 AWES participants categorised...
Épidémiologie des maladies reliées à l’exposition à l’amiante de 1981 à 2012
Incidence et mortalité Cette étude dresse le portrait épidémiologique descriptif des principales maladies reliées à l'exposition à l'amiante, soit l'amiantose, les cancers et les mésothéliomes de la plèvre et du péritoine, à l'exception du cancer du poumon. Elle met à jour les analyses antérieures de l'Institut national de santé publique du Québec sur ces maladies et elle ajoute une description des maladies nouvellement reconnues reliées à une exposition...
Surveillance médico-professionnelle des travailleurs exposés ou ayant été exposés à des agents cancérogènes pulmonaires
Ces recommandations de bonnes pratiques ont pour objectif de définir la surveillance médicoprofessionnelle des travailleurs exposés ou ayant été exposés à des agents cancérogènes pulmonaires, en répondant notamment aux interrogations des professionnels de santé et des travailleurs sur l'opportunité de les faire bénéficier d'un dépistage du cancer broncho-pulmonaire. Élaborées à la demande de la Direction générale du travail par la Société...
Occupation and Thyroid Cancer
A Population-Based, Case-Control Study in Connecticut Objective: The study aims to explore the associations between various occupations and thyroid cancer risk. Methods: A population-based, case-control study involving 462 histologically confirmed incident cases and 498 controls was conducted in Connecticut in 2010 to 2011. Results: A significantly increased risk of thyroid cancer, particularly papillary microcarcinoma, was observed for those working as the health care practitioners and technical workers, health diagnosing and treating practitioners, and registered nurses. Those working in building...
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