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Santé travail : enjeux et actions. Les cancers reconnus d'origine professionnelle. Evolution statistique, actions de prévention et d'accompagnement des salariés exposés
Sur la période 2013-2017, l'Assurance Maladie - Risques professionnels a reconnu, en moyenne 1 840 cancers d'origine professionnelle par an,soit 0,5 % des nouveaux cas de cancers recensés en France. Sur la même période, plus de 50 000 maladies professionnelles ont été reconnues par an, liées majoritairement à des troubles musculo-squelettiques. Parmi les cancers professionnels reconnus, la part liée à l'amiante est prépondérante (80 % sur la période 2013-2017). Il s'agit de cancers du poumon...
Description par type de cancer des situations professionnelles à risque : synthèse des données du réseau RNV3P
L'ANSES (Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail) et le RNV3P (Réseau National de Vigilance et de Prévention des Pathologies Professionnelles) mettent en ligne un rapport identifiant les situations professionnelles à risque pour plusieurs types de cancers. Sont abordés les cancers broncho-pulmonaires, les cancers urothéliaux, les hémopathies lymphoïdes matures, les leucémies myéloïdes, le cancer du larynx, le cancer des fosses nasales et des sinus, le cancer...
Revue de la littérature épidémiologique sur le risque de cancer chez les pompiers
Une revue des publications sur le cancer chez les pompiers parues depuis l'analyse documentaire réalisée en 2007 par le CIRC a été entreprise dans le but de mettre en évidence de nouvelles preuves de liens ou des indicateurs d'associations possibles entre la profession de pompier et le cancer. Cette revue de la littérature a porté sur 21 sièges de cancer à l'égard desquels certaines preuves de lien non concluantes étaient ressorties des revues antérieures. Plus de 600 publications sur l'exposition...
Dutch Committee On Occupational Safety Releases Report On Diesel Engine Exhaust
The Dutch Committee on Occupational Safety (DECOS) of the Health Council of the Netherlands has released a report summarizing the health effects of diesel engine exhaust. The report includes estimates of health-based occupational cancer risk values, and concludes that there is no safe exposure concentration below which no adverse health effects occur. Source : https://www.healthcouncil.nl/documents/advisory-reports/2019/03/13/diesel-engine-exhaust
IARC Scientific Publication No. 165: Tumour Site Concordance and Mechanisms of Carcinogenesis
The International Agency for Research on Cancer (IARC) has published a new Scientific Publication that reviews the information on cancer sites and mechanistic events for the more than 100 agents classified in Group 1 (carcinogenic to humans) by the IARC Monographs Programme. This publication is based on a systematic identification and comparison of the cancer sites observed in humans and those observed in experimental animals, as well as a compilation of mechanistic events for agents known to cause cancer in humans. Relevant information was analysed on all the agents classified in Group 1 in IARC...
Agents fibrogènes et cancérogènes dans les mines d’or et de fer du Québec - Étude exploratoire
De récentes études ont mis en évidence que les travailleurs des mines d’or du Dakota et des mines de fer du Minnesota sont exposés à des particules minérales allongées (PMA). En particulier, les mineurs du Minnesota présentent un risque plus élevé de décès par cancer du poumon, par mésothéliome et par maladies cardiaques que la population générale. Comme l’intérêt renouvelé pour l’exploration de nouveaux gisements d’or et de fer dans le Nord...
Asbestos: Modern Insights for Toxicology in the Era of Engineered Nanomaterials
Asbestos fibers are naturally occurring silicates that have been extensively used in the past, including house construction, but because of their toxicity, their use has been banned in 63 countries. Despite this, more than one million metric tons of asbestos are still consumed annually in countries where asbestos use has not been banned. Asbestos-related disease incidence is still increasing in several countries, including those countries that banned the use of asbestos more than 30 years ago. We highlight here recent knowledge obtained in experimental models about the mechanisms leading to tumor...
Cancer de la vessie et expositions professionnelles aux fluides de coupe
Étude épidémiologique parmi les travailleurs de la sidérurgie en France L'objectif de cette étude est de rechercher s'il existe un risque de cancer de la vessie associé à des expositions professionnelles à des brouillards d'huiles, issus de l'utilisation d'huiles entières ou de fluides aqueux. Une étude cas-témoins a été mise en place au sein d'une cohorte de 22 795 travailleurs de la sidérurgie du Nord - Pas-de-Calais. Les cas de cancer de vessie ont été diagnostiqués...
Welding, Molybdenum Trioxide, and Indium Tin Oxide
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 118 This volume of the IARC Monographs provides evaluations of the carcinogenicity of welding and welding fumes, molybdenum trioxide, and indium tin oxide. Worldwide, an estimated 11 million workers have a job title of welder, and around 110 million additional workers probably incur welding-related exposures. Welding can involve exposures to fumes, gases, ultraviolet radiation and electromagnetic fields, and co-exposures to asbestos and solvents. The extent and type of exposure can depend on the process used, the material...
Occupational exposure to benzene, toluene, xylene and styrene and risk of prostate cancer in a population-based study
Objectives: While several monocyclic aromatic hydrocarbons are classified as definite or possible carcinogens to humans, little data exist on their role in prostate cancer (PCa). We examined occupational exposure to benzene, toluene, xylene (BTX) and styrene and PCa risk in a population-based case–control study in Montreal, Canada. Methods: Cases aged ≤75 years diagnosed with PCa in 2005–2009 (n=1920) and population controls frequency-matched on age (n=1989) provided detailed work histories. Experts evaluated the certainty, frequency and concentration of exposure to monocyclic aromatic...
Expositions professionnelles à des agents cancérogènes respiratoires chez les salariés en 2010
Introduction – Les cancers respiratoires sont les plus fréquents des cancers professionnels, mais très peu de données sont disponibles pour quantifier l'exposition professionnelle aux cancérogènes respiratoires. L'objectif de ce travail était d'évaluer en France la proportion de salariés exposés à des agents cancérogènes respiratoires et d'identifier les groupes professionnels les plus exposés, à des fins de prévention. Méthode – À partir des données...
Case-control investigation of occupational exposure to chlorinated solvents and non-Hodgkin’s lymphoma
Objectives: Although many studies have investigated the association between trichloroethylene (TCE) exposure and non-Hodgkin's lymphoma (NHL), less is known about other chlorinated solvents. We extended our previous analysis of occupational TCE exposure in a multicentre population-based case-control study of NHL to investigate associations with five additional chlorinated solvents: 1,1,1,-trichloroethane, carbon tetrachloride, chloroform, methylene chloride and perchloroethylene. Methods: Cases (n=1189) and controls (n=982) provided detailed information on their occupational histories and workplace...
Burden of lung cancer attributable to occupational diesel engine exhaust exposure in Canada
Objective: To estimate the population attributable fraction (PAF) and number of incident and fatal lung cancers in Canada from occupational exposure to diesel engine exhaust (DEE). Methods: DEE exposure prevalence and level estimates were used with Canadian Census and Labour Force Survey data to model the exposed population across the risk exposure period (REP, 1961–2001). Relative risks of lung cancer were calculated based on a meta-regression selected from the literature. PAFs were calculated using Levin's equation and applied to the 2011 lung cancer statistics obtained from the Canadian...
Cas incidents des maladies à déclaration obligatoire reliées à une exposition professionnelle à l’amiante dans le Système MADO-Chimique, Québec, 2006 – 2015
L'analyse des 2 234 cas incidents de maladies à déclaration obligatoire (MADO) reliées à une exposition professionnelle à l'amiante enregistrés dans le système MADO-Chimique entre 2006 et 2015 montre que : 98 % des cas sont des hommes. Chez les femmes, les mésothéliomes sont les maladies reliées à l'exposition à l'amiante les plus fréquentes, alors que chez les hommes ce sont les amiantoses qui prédominent. Près de 60 % des cas d'amiantose, près de 50 % des cas de...
Occupational exposure to organic solvents and risk of male breast cancer
A European multicenter case-control study Objectives: The etiology of male breast cancer (MBC) is largely unknown but a causal role of exposure to organic solvents has been suggested. Previous studies on occupational risk factors of breast cancer were often restricted to women who are frequently exposed to lower levels and at a lower frequency than men. We investigated the association between MBC and occupational exposure to petroleum and oxygenated and chlorinated solvents in a multicenter case–control study of rare cancers in Europe. Methods: The study included 104 MBC cases and 1901 controls...
Investigation d'une suspicion d'un excès de cas de cancer dans un laboratoire de recherche
Une suspicion d'agrégat de cancers chez des personnels d'un laboratoire de recherche a été investiguée par Santé publique France et sa cellule d'intervention en région Rhône-Alpes (Cire), en lien avec les services de médecine de prévention concernés. Pour les neuf cas signalés, l'investigation a porté sur i) l'identification des cas, ii) la reconstitution des parcours et expositions professionnels au sein du laboratoire, iii) une recherche bibliographique des caractéristiques épidémiologiques...
State of the evidence 2017: an update on the connection between breast cancer and the environment
Singly and in combination, these toxicants may have contributed significantly to the increasing rates of breast cancer observed over the past several decades. Exposures early in development from gestation through adolescence and early adulthood are particularly of concern as they re-shape the program of genetic, epigenetic and physiological processes in the developing mammary system, leading to an increased risk for developing breast cancer. In the 8 years since we last published a comprehensive review of the relevant literature, hundreds of new papers have appeared supporting this link, and in...
Firefighters and cancer: the epidemiological evidence
It is recognised that firefighters can be exposed to many different harmful substances. In 2007 the International Agency for Research on Cancer convened a working group to assess the carcinogenicity of a variety of occupations, increased rates of testicular, prostate and non-Hodgkin's lymphoma were identified for firefighting. This report examines the research published since an IOM review for the UK Industrial Injuries Advisory Council, by carrying out a systematic review and meta-analyses of the epidemiological evidence for specific cancers in firefighters. In total 304 publications were...
Les actes du Forum sur les cancérogènes professionnels maintenant en ligne
En avril 2017, l'IRSST a organisé le Forum sur l'exposition aux cancérogènes professionnels. Ce forum a permis de faire le point sur le fardeau des cancers professionnels au Québec et sur des stratégies de prévention actuelles ou potentielles. Les actes du Forum sont maintenant disponibles en ligne. Certaines présentations PowerPoint des conférenciers peuvent également être consultées, ainsi que les fiches d'information sur les quatre substances qui ont fait l'objet de discussions soit : -l'amiante,...
Exposition des salariés à de multiples nuisances cancérogènes en 2010
Introduction – Les facteurs professionnels susceptibles d'augmenter les risques de cancer sont généralement étudiés séparément les uns des autres, alors que les expositions aux agents cancérogènes sont souvent multiples. L'objectif de ce travail était de fournir des indicateurs d'exposition des salariés à un ensemble de cancérogènes, chimiques ou non, et d'identifier des groupes de salariés particulièrement exposés à des fins de prévention. Méthode...
Lung Cancer Among Firefighters
Smoking-Adjusted Risk Estimates in a Pooled Analysis of Case-Control Studies Objectives: The aim of this study was to explore lung cancer risk among firefighters, with adjustment for smoking. Methods: We used pooled information from the SYNERGY project including 14 case-control studies conducted in Europe, Canada, New Zealand, and China, with lifetime work histories and smoking habits for 14,748 cases of lung cancer and 17,543 controls. We estimated odds ratios by unconditional logistic regression with adjustment for smoking and having ever been employed in a job known to present an excess risk...
Association Between Kidney Cancer and Occupational Exposure to Trichloroethylene
Objective: This study investigates the association between occupational exposure to trichloroethylene (TCE) and kidney cancer, as this correlation has been questioned. Methods: The incidence of cancers was studied in a dynamic cohort of 997 male workers who for many years had been occupationally exposed to TCE. Results: During a 50-year observation period, 13 cases of kidney cancer were observed (7.5 expected) with a standardized incidence ratio of 1.7 and a 95% confidence interval of 1.0 to 3.0. Four other cases, not included in the SIR analysis, were also observed. Long-term TCE exposure was...
Breast cancer incidence among female flight attendants
Exposure–response analyses In a cohort of 6093 female flight attendants, breast cancer incidence was not associated with cumulative exposure to cosmic radiation or two metrics of circadian rhythm disruption. Positive exposure–response relations were observed only in the small subset of the cohort with parity of three or more. Cautious interpretation of the findings in women with high parity is warranted. Source: Pinkerton LE, Hein MJ, Anderson JL, Little MP, Sigurdson AJ, Schubauer-Berigan MK. Scand J Work Environ Health , 2016. http://dx.doi.org/10.5271/sjweh.3586
Occupation and Risk of Bladder Cancer in Nordic Countries
Objective: The purpose of the study was to describe the variation of bladder cancer incidence according to occupational categories in the Nordic countries. Methods: The study cohort comprised 15 million individuals older than 30 years who participated in one or more population censuses in 1960, 1970, 1980/1981, and/or 1990. Standardized incidence ratios (SIRs) were estimated for 53 occupational categories. Results: Significantly increased SIRs were observed among tobacco workers (1.57; 95% confidence interval [CI] 1.24 to 1.96), chimney sweeps (1.48; 95% CI 1.21 to 1.80), waiters (1.43; 95% CI...
Professional Cleaning Activities and Lung Cancer Risk Among Women
Results From the ICARE Study Objectives: Lung cancer risk associated with occupational cleaning activities has been investigated in the population-based case–control study ICARE. Methods: Occupational history was collected by standardized interviews. Jobs were first defined according to the International Standard Classification of Occupations (ISCO) codes and then categorized according to activity sectors. Adjusted odds ratios (ORs) were estimated by unconditional logistic regression, separately for women (619 cases and 760 controls) and men (2265 and 2780). Results: Thirty percent of women...
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