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Valeur toxicologique de référence pour le chlorure de vinyle : Avis de l’Anses Rapport d’expertise collective
Dans le cadre du programme de travail de l'Anses sur les VTRs cancérogènes, une phase pilote a été organisée afin de s'assurer de la mise en pratique de la méthode de construction proposée. Des profils toxicologiques et des VTRs ont été construits sous formes de prestation pour le benzène, le cadmium, l'éthanol, le naphtalène et le chlorure de vinyle. Source : http://www.anses.fr/Documents/CHIM2009sa0348Ra.pdf
IARC: Diesel engine exhaust carcinogenic
After a week-long meeting of international experts, the International Agency for Research on Cancer (IARC), which is part of the World Health Organization (WHO), classified diesel engine exhaust as carcinogenic to humans (Group 1), based on sufficient evidence that exposure is associated with an increased risk for lung cancer. Source : http://www.iarc.fr/en/media-centre/iarcnews/2012/mono105-info.php
Substances cancérogènes
Portrait de l’exposition des travailleurs québécois La liste des substances et conditions de travail associées à un risque élevé de cancer en milieu de travail ne cesse d’augmenter et la CSST a placé les substances cancérogènes parmi les priorités de son plan de mise en œuvre 2008-2010. L’IRSST travaille depuis des années sur certains cancérogènes avérés (selon le Centre international de recherche sur le cancer), tels que le béryllium et la silice. Cependant, afin...
Nouvelles fiches pour repérer et substituer les cancérogènes. Enrichissement de la collection des fiches FAR FAS
10 nouvelles fiches d'aide au repérage ou à la substitution d'agents cancérogènes sont actuellement disponibles. Par ailleurs, 4 fiches existantes viennent d'être mises à jour. La prévention du risque cancérogène passe par 2 phases incontournables, un repérage préalable et une recherche de solutions de substitution (lorsqu'un risque d'exposition à un agent cancérogène a été mis en évidence). Afin d'aider les entreprises dans ces 2 étapes, des fiches...
L'ANSES demande que l’Agence européenne des substances chimiques classe le formaldéhyde comme cancérogène
L'ANSES a déposé, auprès de l'Agence européenne des substances chimiques (ECHA), une proposition de révision du classement du formaldéhyde en vue d'un classement cancérogène plus sévère au niveau européen. Cette dernière consulte actuellement les autres états-membres sur cette proposition de la France. Deux textes réglementaires européens régissent actuellement les substances chimiques : •le règlement Reach : fixe les règles d'enregistrement, d'évaluation...
Mesothelioma mortality in Great Britain: The revised risk and two-stage clonal expansion models
Asbestos is a known carcinogen that is the cause of the majority of mesothelioma cases worldwide. Various models have been used to describe the increase and likely future pattern of mesothelioma rates seen in many western countries - a legacy of past heavy industrial asbestos use. Following on from previous work (Tan and Warren, 2009), we analysed female mesothelioma mortality using the same risk model that was assumed for males. We also analysed mesothelioma mortality in males in Great Britain using two alternative risk models; the first is based on asbestos import data where the population is...
US adds formaldehyde to list of carcinogens
As reported by Reuters, the U.S. government has added formaldehyde, a substance found in plastics and other commonly used products, to a list of known carcinogens and warned that the chemical styrene might cause cancer. In a report prepared for the Secretary of the Department of Health and Human Services (HHS), scientists warned that people with higher exposure to formaldehyde were more at risk for nasopharyngeal cancer, myeloid leukaemia and other cancers. Source : http://www.hazmatmag.com/news/us-adds-formaldehyde-to-list-of-carcinogens/1000473080/
New Substances Added to HHS Report on Carcinogens
The Department of Health and Human Services (HHS) has added eight substances to its Report on Carcinogens, a science-based document that identifies chemicals and biological agents that may put people at increased risk for cancer. The Report on Carcinogens now includes 240 listings Source : http://www.nih.gov/news/health/jun2011/niehs-10.htm
Work exposure to diesel fumes tied to lung cancer
The study has a number of key limitations, one being a lack of data on the subjects' actual exposure to diesel exhaust. Moreover, case-control studies can offer only limited evidence of an association between two variables (in this case, diesel-exhaust exposure and lung cancer risk). And they cannot establish the extent to which diesel exhaust might affect any one worker's absolute risk of developing lung cancer. Studies that follow a population of initially healthy people over time offer stronger evidence of whether a particular exposure is related to a disease risk. Straif noted that...
Revue sélective de la littérature (1995 à 2009) sur la cancérogénicité du trichloroéthylène (TCE)
En 1995, un groupe de travail du Centre international de recherche sur le cancer (CIRC – International Agency for Research in Cancer – IARC) a conclu que le trichloroéthylène (trichloroéthène; TCE; numéro d'enregistrement CAS : 79-01-6) pouvait causer le cancer chez les rongeurs de laboratoire, et qu'il était probablement cancérogène pour les humains (IARC, 1995). Afin de déterminer si ces conclusions ont été modifiées de façon notable par les publications scientifiques plus récentes...
Identification of research needs to resolve the carcinogenicity of high-priority IARC carcinogens
The purpose was two-fold: (1) identify research needs to address the information needs and gaps for a more definitive classification, and (2) Create a report that will be of value to funding agencies in determining possible projects to support. For each agent, a common reporting template was used. All templates had the following categories : • Summary • Citation for most recent IARC review • Current evaluation • Exposure and biomonitoring • Cancer in humans • Cancer in experimental animals bull; Mechanisms of carcinogenicity • Research needs and recommendations...
Research Recommendations for Selected IARC-Classified Agents
There are some common occupational agents and exposure circumstances where evidence of carcinogenicity is substantial but not yet conclusive for humans. The objectives are to identify research gaps and needs for twenty agents prioritized for review based on evidence of widespread human exposures and potential carcinogenicity in animals or humans. Source : http://ehp03.niehs.nih.gov/article/fetchArticle.action?articleURI=info%3Adoi%2F10.1289%2Fehp.0901828#top
ECHA adds eight substances to the Candidate List for authorisation
The European Chemicals Agency has added 8 chemical substances to the Candidate List of Substances of Very High Concern (SVHC) for authorisation. Following the unanimous agreement of the Member State Committee, ECHA is adding 8 substances on the Candidate List, which now contains 38 substances in total. The 8 substances, which are carcinogenic, mutagenic or reprotoxic (CMR) substances, are listed below. As foreseen by REACH, a specific procedure will be followed to decide whether the substances should also be included in the authorisation list. Source : http://osha.europa.eu/en/news/eu-echa-adds...
Investigation of potential exposure to carcinogens and respiratory sensitisers during thermal processing of plastics
This work was carried out in support of HSE's FIT3 Disease Reduction Programme Cancer Project's aim to develop a strategy to reduce the incidence of occupational cancer in Great Britain. As part of this strategy, HSE has initiated research that aims to deliver evidence that will help to identify carcinogens of concern, improve control of exposure to carcinogens at work and provide a baseline for evaluating strategies for intervention. Earlier, in 2005-7, HSL characterised the exposure profiles of a selected group of occupational carcinogens and determined baseline exposures with which to...
Guidance for the classification of carcinogens under the Globally Harmonised System of Classification and Labelling of Chemicals (GHS)
The United Nations Conference on Environment and Development (UNCED) has developed criteria for a globally harmonised system of classification and labelling of chemicals (GHS). With regard to carcinogenicity, GHS distinguishes between Category 1 (‘known or presumed human carcinogens') and Category 2 (‘suspected human carcinogens'). Category 1 carcinogens are divided into Category 1A (‘known to have carcinogenic potential for humans'), based largely on human evidence, and 1B (‘presumed to have carcinogenic potential for humans'), based largely on experimental...
A review of human carcinogens
Chemical agents and related occupations In October 2009, 23 scientists from 6 countries met at the International Agency for Research on Cancer (IARC) to re-assess the carcinogenicity of a number of chemical compounds, complex mixtures and occupational exposures previously classified as carcinogenic to humans (Group 1) and to identify additional tumour sites and mechanisms of carcinogenesis. Highlights : http://monographs.iarc.fr/ENG/Monographs/vol100fintro/100F-introduction.pdf Summary : http://monographs.iarc.fr/ENG/Monographs/vol100f/Summary%20of%20Evaluations%20-%20Master%20set%20posted%20online...
Exploratory survey of Occupational Exposure Limits (OELs)
Exploratory survey of Occupational Exposure Limits (OELs) for Carcinogens, Mutagens and Reprotoxic substances (CMRs) at EU Member States level This report is based on a one-off survey carried out late 2007-early 2008 among EU-OSHA's network partners at the request of the European Commission. Rather than presenting an in-depth study of the systems in place for setting occupational exposure limits (OELs) for carcinogenic, mutagenic and reprotoxic substances, this report provides a general overview of the situation in 21 Member States. In recent years, all Member States have made available their...
Dangerous chemicals putting workers' lives at risk says TUC
Employers who risk the future health of their employees by exposing them to cancer-causing chemicals at work should be prosecuted under UK safety laws, says the TUC today (Thursday) as it produces a new guide for unions. Launching a campaign to raise awareness of the toxic chemicals and substances such as wood dust and diesel particles that can make workers ill sometimes years after leaving their jobs, the TUC guide aims to help union safety reps keep up the pressure on employers to make workplaces safer, and stop them from taking unnecessary risks with their employees' lives. http://www.tuc...
Reducing Cytotoxic Drug Exposure in Healthcare: Determinants Influencing Cleaning Effectiveness
Many cytotoxic drugs used to treat cancer and other diseases are known to be carcinogenic or mutagenic. Health care workers who handle these drugs may be at risk of developing adverse health effects such as organ toxicities, reproductive problems, tumours, and cancer. Although several guidelines for cytotoxic drug handling exist, studies have shown that contamination can occur even when proper engineering controls are in place. Using laboratory research methods, this project examined the effectiveness of the cleaning agents used to clean surfaces contaminated with the three cytotoxic drugs most...
American Experts Say Cancer Prevention Efforts Currently Lacking
The United States federal government has done surprisingly little to assess and reduce workplace exposures to carcinogens, according to a former chief regulatory official with the American Occupational Safety and Health Administration (OSHA). http://www.whsc.on.ca/whatnews2.cfm?autoid=489
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