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Study on reprotoxic chemicals
A range of legislative instruments are in place at EU level to manage and minimise the risks from occupational exposure to carcinogenic, mutagenic and reprotoxic substances. Carcinogenic chemicals can cause or promote cancers. Mutagenic chemicals can cause genetic mutations. Reprotoxic chemicals can damage the reproductive process. This study assesses a number of options for moderning the current EU legislation, in particular regarding reprotoxic chemicals Source: https://ec.europa.eu/social/main.jsp?catId=738&langId=en&pubId=8220&furtherPubs=yes
IARC Scientific Publication No. 165: Tumour Site Concordance and Mechanisms of Carcinogenesis
The International Agency for Research on Cancer (IARC) has published a new Scientific Publication that reviews the information on cancer sites and mechanistic events for the more than 100 agents classified in Group 1 (carcinogenic to humans) by the IARC Monographs Programme. This publication is based on a systematic identification and comparison of the cancer sites observed in humans and those observed in experimental animals, as well as a compilation of mechanistic events for agents known to cause cancer in humans. Relevant information was analysed on all the agents classified in Group 1 in IARC...
Agents fibrogènes et cancérogènes dans les mines d’or et de fer du Québec - Étude exploratoire
De récentes études ont mis en évidence que les travailleurs des mines d’or du Dakota et des mines de fer du Minnesota sont exposés à des particules minérales allongées (PMA). En particulier, les mineurs du Minnesota présentent un risque plus élevé de décès par cancer du poumon, par mésothéliome et par maladies cardiaques que la population générale. Comme l’intérêt renouvelé pour l’exploration de nouveaux gisements d’or et de fer dans le Nord...
Carcinogenicity of some nitrobenzenes and other industrial chemicals
In October, 2018, 14 experts from six countries met at the International Agency for Research on Cancer (IARC) in Lyon, France, to finalise their evaluation of the carcinogenicity of ortho-phenylenediamine and its dihydrochloride salt, 2-chloronitrobenzene, 4-chloronitrobenzene, 1,4-dichloro-2-nitrobenzene, 2,4-dichloro-1-nitrobenzene, 2-amino-4-chlorophenol, para-nitroanisole, and N,N-dimethylacetamide. These assessments will be published in Volume 123 of the IARC Monographs. Source: (2018). The Lancet Oncology . https://doi.org/10.1016/S1470-2045(18)30823-4
Welding, Molybdenum Trioxide, and Indium Tin Oxide
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 118 This volume of the IARC Monographs provides evaluations of the carcinogenicity of welding and welding fumes, molybdenum trioxide, and indium tin oxide. Worldwide, an estimated 11 million workers have a job title of welder, and around 110 million additional workers probably incur welding-related exposures. Welding can involve exposures to fumes, gases, ultraviolet radiation and electromagnetic fields, and co-exposures to asbestos and solvents. The extent and type of exposure can depend on the process used, the material...
Recent trends in the industrial use and emission of known and suspected carcinogens in Ontario, Canada
BACKGROUND: In 2010, Ontario, Canada's most populous province, implemented its Toxics Reduction Act, Ontario Regulation 455/09 (TRA), which requires four major manufacturing and mineral processing industry groups that already report releases of pollutants federally to the National Pollutant Release Inventory to additionally track, account and report their use and creation. The TRA was modeled after the Massachusetts Toxics Use Reduction Act of 1989, which has been very successful and reported significant reduction in toxic use and carcinogen release. METHODS: Data from the TRA were retrieved...
IARC Monographs Volume 112: Some Organophosphate Insecticides and Herbicides
This volume of the IARC Monographs provides evaluations of the carcinogenicity of some organophosphate insecticides and herbicides, including diazinon, glyphosate, malathion, parathion, and tetrachlorvinphos. Diazinon acts on a wide range of insects on crops, gardens, livestock, and pets, but most uses have been restricted in the USA, Canada, and the European Union since the 1980s. Glyphosate is the most heavily used agricultural and residential herbicide in the world, and has been detected in soil, air, surface water, and groundwater, as well as in food. Malathion is one of the oldest and most...
Exposition des salariés à de multiples nuisances cancérogènes en 2010
Introduction – Les facteurs professionnels susceptibles d'augmenter les risques de cancer sont généralement étudiés séparément les uns des autres, alors que les expositions aux agents cancérogènes sont souvent multiples. L'objectif de ce travail était de fournir des indicateurs d'exposition des salariés à un ensemble de cancérogènes, chimiques ou non, et d'identifier des groupes de salariés particulièrement exposés à des fins de prévention. Méthode...
Exposition des travailleurs québécois à des cancérogènes
Industries et groupes professionnels Les substances étudiées sont classées comme cancérogène « démontré » ou « soupçonné » chez l'humain (notations C1 et C2, respectivement) ou « démontré » chez l'animal (C3), selon l'annexe 1 du Règlement sur la santé et la sécurité du travail, ou encore comme cancérogène « avéré » ou « probable » pour l'humain (groupes 1 et 2A, respectivement), selon le...
IARC Monographs Volume 111: Some Nanomaterials and Some Fibres
This volume of the IARC Monographs contains evaluations of the carcinogenic hazard to humans of fluoro-edenite fibrous amphibole, silicon carbide fibres and whiskers, and carbon nanotubes. None of these agents had been evaluated previously by the Working Group. Source: http://monographs.iarc.fr/ENG/Monographs/vol111/index.php
Surveillance médico-professionnelle des travailleurs exposés ou ayant été exposés à des agents cancérogènes pulmonaires
Ces recommandations de bonnes pratiques ont pour objectif de définir la surveillance médicoprofessionnelle des travailleurs exposés ou ayant été exposés à des agents cancérogènes pulmonaires, en répondant notamment aux interrogations des professionnels de santé et des travailleurs sur l'opportunité de les faire bénéficier d'un dépistage du cancer broncho-pulmonaire. Élaborées à la demande de la Direction générale du travail par la Société...
Carcinogens that should be subject to binding limits on workers’ exposure
The objective of this publication is the identification of at least 70 carcinogens that are relevant for workers’ exposure via inhalation at a considerable number of workplaces in Europe and thus, for which a Binding Occupational Exposure Limits (BOEL) under the Carcinogens and Mutagens Directive (CMD) might be suggested. Source: http://www.etui.org/Publications2/Reports/Carcinogens-that-should-be-subject-to-binding-limits-on-workers-exposure
Carcinogenicity of some industrial chemicals
In February 2016, 24 experts from eight countries met at the International Agency for Research on Cancer (IARC), Lyon, France, to assess the carcinogenicity of seven industrial chemicals (appendix). These assessments will be published as volume 115 of the IARC Monographs. Source: Yann Grosse, Dana Loomis, Kathryn Z Guyton, Fatiha El Ghissassi, Véronique Bouvard, Lamia Benbrahim-Tallaa, Heidi Mattock, Kurt Straif. The Lancet Oncology , 2016. http://dx.doi.org/10.1016/S1470-2045(16)00137-6
Les expositions aux cancérogènes, mutagènes et reprotoxiques
Un zoom sur huit produits chimiques Les améliorations sont cependant hétérogènes. L'analyse des huit agents CMR qui touchent le plus de salariés montre que l'exposition au formaldéhyde, au plomb, à l'amiante et aux poussières de bois a fortement diminué tandis que celles à d'autres produits comme la silice cristalline ou les phtalates, important reprotoxique, a plutôt augmenté. Les mesures de protections efficaces contre les produits comme les gaz d'échappement diesel ou les huiles minérales...
Exposure to carcinogens and work-related cancer
A review of assessment methods Estimates of the recent and future burden of occupational diseases indicate that occupational cancer is still a major problem and will remain so in the future as a result of exposure of workers to carcinogens. That's why occupational cancer is a problem that needs to be tackled across the European Union. This summary provides a short overview of assessment tools for the exposure to cancer risk factors and looks into relevant occupational factors: chemical, physical and biological exposures, as well as other possibly carcinogenic working environment conditions...
IARC evaluation of five organophosphate pesticides
A Working Group of 17 experts from 11 countries met at the International Agency for Research on Cancer (IARC), the specialized cancer agency of the World Health Organization on 3-10 March 2015 to review the available published scientific evidence and evaluate the carcinogenicity of five organophosphate insecticides and herbicides: diazinon, glyphosate, malathion, parathion, and tetrachlorvinphos. A summary of the final evaluations together with a short rationale have now been published online in The Lancet Oncology , and the detailed assessments will be published as Volume 112 of the IARC Monographs...
Exposure to carcinogens and work-related cancer
A review of assessment methods Occupational cancer is a problem that needs to be tackled across the European Union (EU). Estimates of the recent and future burden of occupational diseases indicate that occupational cancer is still a problem and will remain so in the future as a result of exposure of workers to carcinogens. The goals to which this review aims to contribute are to: - describe occupational exposure to carcinogens and cancer-causing or -promoting working conditions at European, national and workplace levels; - evaluate existing sources of information, identify major knowledge gaps...
Risk of congenital malformations among children of construction painters in Denmark
A nationwide cohort study Objectives: Painters' occupational exposure is classified as a group 1 carcinogen by the International Agency for Research on Cancer (IARC). Previous studies have shown increased risk of congenital malformations among children of women exposed to organic solvents and paint emissions during pregnancy. In Denmark, women comprise half of those enrolled in vocational paint training. We investigated the association between maternal and paternal occupational painting, respectively, and the risk of congenital malformations among children. Methods: National register data were...
Australian Work Exposures Study (AWES) - Polycyclic aromatic hydrocarbons (PAHs)
The Australian Work Health and Safety Strategy 2012-2022 (the Strategy) describes work-related cancer as a priority disorder and understanding current hazardous exposures and the effectiveness of controls as a research priority. The Australian Work Exposures Study (AWES) was a national survey that investigated work-related exposures among Australian workers to 38 agents classified by the International Agency for Research on Cancer (IARC) as known or suspected carcinogens. Some polycyclic aromatic hydrocarbons (PAHs) are classified as a known or suspected human carcinogens by the IARC and the work...
Australian Work Exposures Study (AWES) - Formaldehyde
The Australian Work Health and Safety Strategy 2012-2022 (the Strategy) describes work-related cancer as a priority disorder and understanding current hazardous exposures and the effectiveness of controls as a research priority. The Australian Work Exposures Study (AWES) was a national survey that investigated work-related exposures among Australian workers to 38 agents classified by the International Agency for Research on Cancer (IARC) as known or suspected carcinogens. Formaldehyde is classified as a known human carcinogen by the IARC and the work described in this report uses AWES data to:...
Australian Work Exposures Study (AWES) - Lead and lead compounds
The Australian Work Health and Safety Strategy 2012-2022 (the Strategy) describes work-related cancer as a priority disorder and understanding current hazardous exposures and the effectiveness of controls as a research priority. The Australian Work Exposures Study (AWES) was a national survey that investigated work-related exposures among Australian workers to 38 agents classified by the International Agency for Research on Cancer (IARC) as known or suspected carcinogens. Some forms of lead are considered to be probable carcinogens and the work described in this report uses AWES data to: •...
Nouvelle fiche pour repérer les cancérogènes
Une nouvelle fiche d'aide au repérage (FAR) de produits cancérogènes vient d'être publiée, concernant l'entretien des espaces verts. Par ailleurs, 15 fiches FAR et une fiche FAS existantes viennent d'être mises à jour. La liste complète des 87 fiches actuellement disponibles dans la collection des FAR ou des FAS (aide à la substitution) est également proposée. Source: http://www.inrs.fr/accueil/header/actualites/nouvelles-far-fas.html
The association of the original OSHA chemical hazard communication standard with reductions in acute work injuries/illnesses in private industry and the industrial releases of chemical carcinogens
OSHA predicted the original chemical Hazard Communication Standard (HCS) would cumulatively reduce the lost workday acute injury/illness rate for exposure events by 20% over 20 years and reduce exposure to chemical carcinogens. METHODS: JoinPoint trend software identified changes in the rate of change of BLS rates for days away from work for acute injuries/illnesses during 1992-2009 for manufacturing and nonmanufacturing industries for both chemical, noxious or allergenic injury exposure events and All other exposure events. The annual percent change in the rates was used to adjust observed numbers...
Opportunities for cancer prevention: trends in the use and release of carcinogens in Massachusetts
The report draws on 20 years of data collected from industries reporting to the Massachusetts Toxic Use Reduction Act program to assess trends in the use and release of chemicals associated with cancer. The analysis shows that reported use and releases of carcinogens among Massachusetts companies have decreased dramatically over time. Reported use declined 32% from 1990 to 2010, and reported releases declined 93% from 1991 to 2010. The report also groups the chemicals by their links with eleven specific types of cancer: bladder; brain and central nervous system; breast; kidney; leukemia; liver;...
Nouvelles fiches pour repérer et substituer les cancérogènes
3 nouvelles fiches d'aide au repérage ou à la substitution d’agents cancérogènes sont actuellement disponibles. Par ailleurs, 19 fiches existantes viennent d’être mises à jour (dont 3 refondues, notamment celle concernant la substitution du perchloroéthylène). Source : http://www.inrs.fr/accueil/header/actualites/nouvelles-far-fas.html
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