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IARC Scientific Publication No. 165: Tumour Site Concordance and Mechanisms of Carcinogenesis
The International Agency for Research on Cancer (IARC) has published a new Scientific Publication that reviews the information on cancer sites and mechanistic events for the more than 100 agents classified in Group 1 (carcinogenic to humans) by the IARC Monographs Programme. This publication is based on a systematic identification and comparison of the cancer sites observed in humans and those observed in experimental animals, as well as a compilation of mechanistic events for agents known to cause cancer in humans. Relevant information was analysed on all the agents classified in Group 1 in IARC...
Agents fibrogènes et cancérogènes dans les mines d’or et de fer du Québec - Étude exploratoire
De récentes études ont mis en évidence que les travailleurs des mines d’or du Dakota et des mines de fer du Minnesota sont exposés à des particules minérales allongées (PMA). En particulier, les mineurs du Minnesota présentent un risque plus élevé de décès par cancer du poumon, par mésothéliome et par maladies cardiaques que la population générale. Comme l’intérêt renouvelé pour l’exploration de nouveaux gisements d’or et de fer dans le Nord...
IARC evaluation of five organophosphate pesticides
A Working Group of 17 experts from 11 countries met at the International Agency for Research on Cancer (IARC), the specialized cancer agency of the World Health Organization on 3-10 March 2015 to review the available published scientific evidence and evaluate the carcinogenicity of five organophosphate insecticides and herbicides: diazinon, glyphosate, malathion, parathion, and tetrachlorvinphos. A summary of the final evaluations together with a short rationale have now been published online in The Lancet Oncology , and the detailed assessments will be published as Volume 112 of the IARC Monographs...
Risk of congenital malformations among children of construction painters in Denmark
A nationwide cohort study Objectives: Painters' occupational exposure is classified as a group 1 carcinogen by the International Agency for Research on Cancer (IARC). Previous studies have shown increased risk of congenital malformations among children of women exposed to organic solvents and paint emissions during pregnancy. In Denmark, women comprise half of those enrolled in vocational paint training. We investigated the association between maternal and paternal occupational painting, respectively, and the risk of congenital malformations among children. Methods: National register data were...
Investigation of potential exposure to carcinogens and respiratory sensitisers during thermal processing of plastics
This work was carried out in support of HSE's FIT3 Disease Reduction Programme Cancer Project's aim to develop a strategy to reduce the incidence of occupational cancer in Great Britain. As part of this strategy, HSE has initiated research that aims to deliver evidence that will help to identify carcinogens of concern, improve control of exposure to carcinogens at work and provide a baseline for evaluating strategies for intervention. Earlier, in 2005-7, HSL characterised the exposure profiles of a selected group of occupational carcinogens and determined baseline exposures with which to...
Reducing Cytotoxic Drug Exposure in Healthcare: Determinants Influencing Cleaning Effectiveness
Many cytotoxic drugs used to treat cancer and other diseases are known to be carcinogenic or mutagenic. Health care workers who handle these drugs may be at risk of developing adverse health effects such as organ toxicities, reproductive problems, tumours, and cancer. Although several guidelines for cytotoxic drug handling exist, studies have shown that contamination can occur even when proper engineering controls are in place. Using laboratory research methods, this project examined the effectiveness of the cleaning agents used to clean surfaces contaminated with the three cytotoxic drugs most...

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