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Conditions reliées à l’exposition au béryllium au Québec : 1999-2011
Les dossiers médicaux de 123 travailleurs ayant soumis une réclamation à la Commission des normes, de l'équité, de la santé et de la sécurité du travail (CNESST) pour une condition reliée à l'exposition au béryllium entre le 1er janvier 1999 et le 31 décembre 2011 ont été analysés. Trois formes distinctes de conditions reliées au béryllium ont été étudiées, soit : la sensibilisation au béryllium, la bérylliose chronique asymptomatique...
Analyse des biomarqueurs dans le condensat de l’air exhalé dans une population de salariés exposés professionnellement au béryllium et/ou ses composés
Métal incontournable dans les industries de pointe à fortes contraintes thermiques et mécaniques, le béryllium peut provoquer une bérylliose pulmonaire chronique (BPC), précédée par un état de sensibilisation au béryllium (SeBe). La valeur limite d'exposition professionnelle sur 8 heures actuellement en vigueur en France insuffisamment protectrice, l'augmentation prévisible du nombre de sujets professionnellement exposés, la latence longue d'apparition de la BPC et l'absence d'outils standardisés...
Research to Practice Implications of High-Risk Genotypes for Beryllium Sensitization and Disease
Objective: Beryllium workers may better understand their genetic susceptibility to chronic beryllium disease (CBD) expressed as population-based prevalence, rather than odds ratios from case-control studies. Methods: We calculated CBD prevalences from allele-specific DNA sequences of 853 workers for Human Leukocyte Antigen (HLA)-DPB1 genotypes and groups characterized by number of E69-containing alleles and by calculated surface electronegativity of HLA-DPB1. Results: Of 18 groups of at least 10 workers with specific genotypes, CBD prevalence was highest, 72.7%, for the HLA-DPB1*02:01:02/DPB1*17...
Exposure Factors Associated With Chronic Beryllium Disease Development in Beryllium BioBank Participants
Objective: To assess the importance of occupational history for beryllium-exposed workers. Methods: Beryllium BioBank data were analyzed for 532 subjects in the following three groups: beryllium-exposed, beryllium-sensitized, and chronic beryllium disease. Predictor variables were several questionnaire-derived exposure indices. Results: Cumulative exposure estimated from a standardized interview contributes to differentiating beryllium-exposed from chronic beryllium disease. The likelihood of progression from sensitization to disease was associated with peak-level weighted exposure hours. Conclusions...
Long-term efficacy of a program to prevent beryllium disease
Background In 2000, a manufacturer of beryllium materials and products introduced a comprehensive program to prevent beryllium sensitization and chronic beryllium disease (CBD). We assessed the program's efficacy in preventing sensitization 9 years after implementation. Methods Current and former workers hired since program implementation completed questionnaires and provided blood samples for the beryllium lymphocyte proliferation test (BeLPT). Using these data, as well as company medical surveillance data, we estimated beryllium sensitization prevalence. Results Cross-sectional prevalence...
Sensitization and chronic beryllium disease at a primary manufacturing facility
Part 1: historical exposure reconstruction Objectives : Previous epidemiologic studies of beryllium sensitization (BeS) and chronic beryllium disease (CBD) have reported inconsistent exposure–response relationships, likely due to exposure misclassification. The objective of this study was to develop historical estimates of size-selective personal exposure to beryllium for an epidemiologic study. Methods : In 1999, a cross-sectional survey of workers hired after 1 January 1994 was conducted at a beryllium production facility. Personal exposure data from two air sampling surveys conducted in...
RR873 - Beryllium: A review of the health effects and the evidence for screening or surveillance in workers exposed to beryllium
As exposure limits for beryllium have decreased, so has the incidence and severity of chronic beryllium disease. There are however an emerging number of cases of subclinical disease and beryllium sensitization (BeS) that are being detected with new immunological tests, namely the beryllium lymphocyte proliferation test (BeLPT). Almost all the recent data on screening beryllium workers relates to the BeLPT, and more traditional screening programmes such as spirometry and chest x-rays that have been in use since the 1950s have only been evaluated as secondary endpoints. Whilst the BeLPT has revolutionised...
Preventing Sensitization and Disease from Beryllium Exposure
Workers exposed to particles, fumes, mists, or solutions from beryllium-containing materials may develop beryllium sensitization or chronic beryllium disease, a potentially disabling or even fatal respiratory disease. Source : http://www.cdc.gov/niosh/docs/2011-107/
Exposition au béryllium des travailleurs de la transformation d'aluminium et du magnésium
Évaluation des paramètres de surveillance environnementale L'objectif principal de cette recherche était de vérifier si les différents indicateurs d'exposition au Be affectent la classification des travailleurs par gammes de concentration. Un objectif secondaire était de caractériser les aérosols aux sources d'émission, en déterminant leur composition chimique et leur distribution granulométrique, afin de favoriser la mise en place de moyens de maîtrise. Source : http://www.irsst.qc.ca/files/documents...
Beryllium Disease in BC Workers
A Pilot Surveillance Project Using Linked Administrative Data Beryllium – a strong, light-weight metal used in several industries – can cause a serious lung disease called Chronic Beryllium Disease (CBD), even at low exposure levels. Although beryllium is used in B.C., no cases of CBD have been diagnosed in the province to date. This could be because CBD can be easily confused with sarcoidosis, another lung disease which can only be distinguished from CBD with a specific diagnostic test. To explore whether unrecognized cases of CBD may have occurred in B.C., the study examined the incidence...
Évaluation de la toxicité du béryllium en fonction de la forme chimique et de la taille des particules
Au cours des dernières années, plusieurs auteurs ont remis en cause le niveau de protection accordé aux travailleurs par la valeur seuil reconnue pour le béryllium (Be) et ses sels (VEMP Québec, TLV (TWA) ACGIH). La prévalence des effets associés au Be suggère que les risques sont en fonction de sa spéciation. Par ailleurs, il semble que les particules fines constituent la fraction d’intérêt pour l’occurrence de tels effets. L’objectif de cette recherche est d’évaluer la toxicité du...
Proceedings of the Third International Symposium on Beryllium Particulates and Their Detection
Special Issue of Journal of Occupational and Environmental Hygiene : Volume 6 Issue 12 2009 Source : http://oeh.informaworld.com/soeh/title~db=all~content=g916671252
Le béryllium, métal discret mais dangereux
Le béryllium est un métal peu connu de ceux qui l'utilisent car il est le plus souvent « caché » dans des alliages ou des céramiques. Mais il est bien connu des spécialistes pour sa dangerosité : il est irritant, allergisant, toxique et cancérogène. On estime qu'environ 12 000 salariés en France y sont exposés. Ce chiffre pourrait aller en augmentant avec le développement du recyclage des métaux. Une démarche de prévention appropriée peut protéger les travailleurs...
Online Guide Explains Safe Uses of Beryllium
"Interactive Guide to Working Safely with Beryllium and Beryllium-containing Materials," a guide that won a 2008 National Occupational Research Agenda Partnering Award for Worker Health and Safety, is now available on the Brush Wellman Inc. Web site. Brush Wellman, the world's largest producer of beryllium and beryllium-containing materials, developed the guide in January 2008 with Axcept Media, LLC, but until now it was available only in disk form. http://ohsonline.com/articles/2009/02/16/online-guide-explains-safe-uses-of-beryllium.aspx

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