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Pneumococcal Vaccination Among Adults With Work-related Asthma
Introduction: Pneumococcal vaccination is recommended for all adults with asthma and a Healthy People 2020 goal aims to achieve 60% coverage among high-risk adults, including those with asthma. Adults with work-related asthma have more severe asthma symptoms than those with non−work-related asthma and are particularly vulnerable to pneumococcal pneumonia. Methods: To assess pneumococcal vaccination coverage by work-related asthma status among ever-employed adults aged 18–64 years with current asthma, data from the 2012–2013 Behavioral Risk Factor Surveillance System Asthma Call...
Rhinite et asthme dans l'industrie pharmaceutique
L'industrie pharmaceutique en France produit chaque année près de 2 800 substances, présentes dans 11 000 spécialités. Parmi celles-ci, les antibiotiques, les enzymes et d'autres substances végétales comme les gommes sont à l'origine de l'essentiel des cas de rhinite ou d'asthme professionnel (AP) rapportés dans la littérature. Toutefois, les données épidémiologiques sont peu nombreuses et la prévalence des cas apparaît comme faible au regard du nombre de substances mises...
The estimated prevalence of exposure to asthmagens in the Australian workforce, 2014
Background: There is very little information available on a national level as to the number of people exposed to specific asthmagens in workplaces. Methods: We conducted a national telephone survey in Australia to investigate the prevalence of current occupational exposure to 277 asthmagens, assembled into 27 groups. Demographic and current job information were obtained. A web-based tool, OccIDEAS, was used to collect job task information and assign exposure to each asthmagen group. Results: In the Australian Workplace Exposure Study – Asthma (AWES- Asthma) we interviewed 4878 participants...
Inflammatory Markers and Genetic Polymorphisms in Workers Exposed to Flour Dust
Objective: The aim of this study is to evaluate inflammatory markers and pro-inflammatory CD14 and Toll-like Receptor 4 (TLR4) polymorphisms in workers exposed to flour dust. Methods: Polymorphisms in TLR4 and CD14 were identified in our study population of 167 workers that included 63 healthy subjects (HS), 45 atopic subjects (A), and 59 subjects diagnosed clinically with occupational asthma/rhinitis (OAR). Endpoint measures in this study included fractional exhaled nitric oxide and serum concentrations of interleukin IL-6, IL-8, and tumor necrosis factor-alpha (TNF-α). Results: We identified...
Pulmonary illness as a consequence of occupational exposure to shrimp shell powder
OBJECTIVES: An employee with no prior history of allergy or asthma, experienced respiratory and flu-like symptoms during production of shrimp shell powder in a seafood savory factory in Norway. We aimed to clarify the diagnosis and to identify the cause of the symptoms by specific inhalation challenge (SIC) and by characterizing the powder's biocontaminants, particle size fractions and inflammatory potential. METHODS: Respiratory and immunological responses were measured the day before and after each of four challenges with 20-150g shrimp shell powder during three consecutive days. The powder...
Exposition à des agents pouvant causer l’asthme professionnel
Utilisation du test d'activation des basophiles pour l'identification précoce de la sensibilisation allergique chez les travailleurs L'asthme professionnel est un type d'asthme causé par un agent présent dans les milieux de travail. Le type principal d'asthme professionnel est celui qui est causé par le développement d'une « allergie » à certains agents présents dans le milieu de travail. La mise en évidence de cette « allergie » est une étape essentielle de l'investigation clinique...
Troubles psychiatriques chez les patients soumis à une évaluation relative à l’asthme professionnel
Prévalence et impact sur la situation d’emploi et l’utilisation des services de santé L’asthme professionnel (AP) est un important problème de santé au travail qui a un impact tant sur le secteur de l’emploi que sur les ressources en santé et l’individu lui-même. Entre 10 % et 30 % des asthmatiques qui le sont devenus à l’âge adulte mentionnent que leur asthme s’aggrave au travail et qu’il est souvent difficile à diagnostiquer et à traiter. La majorité (environ 70 %) des patients...
Asthme professionnel aux sulfites
Cette fiche d'allergologie-pneumologie professionnelle annule et remplace l'ancienne fiche du même nom (TR 17). Elle fait le point sur les sulfites, sels de l'anhydride sulfureux (SO2), qui sont utilisés dans de nombreux secteurs d'activité, notamment pour leurs propriétés antiseptiques et anti-oxydantes. Si l'intolérance aux sulfites, notamment chez les sujets asthmatiques, est bien connue lors de l'ingestion d'aliments ou de boissons, ou lors de l'administration de produits pharmaceutiques en contenant, seuls quelques cas...
L’absence d’éosinophilie bronchique est-elle un facteur de mauvais pronostic de l’asthme professionnel?
L'asthme est une maladie inflammatoire des bronches qui se traduit par une respiration sifflante, de la toux et de la difficulté à respirer. Ces symptômes s'accompagnent de changements de la fonction respiratoire qui comprennent une obstruction des bronches ainsi qu'une irritabilité anormale de celles-ci. L'inflammation présente dans l'asthme correspond la plupart du temps à la présence de cellules appelées éosinophiles. L'asthme professionnel (AP) est un asthme qui est causé par une allergie à un...
Cross-Sectional Survey of Workers Exposed to Aliphatic Diisocyanates Using Detailed Respiratory Medical History and Questions Regarding Accidental Skin and Respiratory Exposures
Objectives: To identify possible cases of occupational asthma and assess accidental skin and inhalation exposures to aliphatic diisocyanates. Methods: Seventy-three employees from two plants, manufacturing or producing aliphatic diisocyanates, were surveyed using a detailed respiratory history questionnaire with additional questions on accidental skin and inhalation exposures. Further reviews of medical records and interviews were used to determine whether any of 15 employees with questionable responses had developed occupational asthma. Results: No cases of occupational asthma were identified...
Asthma related to cleaning agents: a clinical insight
OBJECTIVE : To determine the agents causing asthmatic reactions during specific inhalation challenges (SICs) in workers with cleaning-related asthma symptoms and to assess the pattern of bronchial responses in order to identify the mechanisms involved in cleaning-related asthma. DESIGN : A retrospective case series analysis. SETTING : The study included all participants who completed an SIC procedure with the cleaning/disinfection products suspected of causing work-related asthma over the period 1992-2011 in a tertiary centre, which is the single specialised centre of the French-speaking part of...
Work-related allergic respiratory disease and asthma in spice mill workers is associated with inhalant chili pepper and garlic exposures
Objective The aim of the study was to determine the prevalence and risk factors for allergic respiratory disease in spice mill workers. Methods A cross-sectional study of 150 workers used European Community Respiratory Health Survey questionnaires, Phadiatop, serum specific IgE (garlic, chili pepper), spirometry and fractional exhaled nitric oxide (FeNO). Personal air samples (n=62) collected from eight-hour shifts were analysed for inhalable particulate mass. Novel immunological assays quantified airborne garlic and chili pepper allergen concentrations. Results Mean dust particulate mass (geometric...
Cedar Asthma – Markers of Recovery and Severity
Many workers who develop Western Red Cedar Asthma (WRCA) continue to show respiratory impairment years after exposure to Western Red Cedar has ceased. This project examined the association between continuing WRCA symptoms and biomarkers in sputum and blood serum. A positive association was found between the presence of the biomarker interferon-gamma and impairment level. A second phase of this project investigated the relationship between measures of quality of life and respiratory impairment. Results showed impairment level to be significantly associated with decreased measures of quality of life...
Occupational rhinitis and asthma due to EDTA-containing detergents or disinfectants
Background: Detergents and disinfectants are an emerging cause of work-related rhinitis and asthma. These products may contain ethylenediamine tetraacetic acid (EDTA). The authors report 10 cases of EDTA-related asthma and/or rhinitis. Methods: Review of the medical charts of patients who presented with work-related rhinitis (alone or with asthma), with a history of exposure to aerosols of EDTA-containing products and who underwent a nasal provocation test (NPT) with tetrasodium EDTA (1–4%) in our occupational health unit. Results: Twenty-eight patients underwent a NPT with EDTA, which was...

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