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Behaviour of chemical respiratory allergens in novel predictive methods for skin sensitisation
Asthma resulting from sensitisation of the respiratory tract to chemicals is an important occupational health issue, presenting many toxicological challenges. Most importantly there are no recognised predictive methods for respiratory allergens. Nevertheless, it has been found that all known chemical respiratory allergens elicit positive responses in assays for skin sensitising chemicals. Thus, chemicals failing to induce a positive response in skin sensitisation assays such as the local lymph node assay (LLNA) lack not only skin sensitising activity, but also the potential to cause respiratory...
Thresholds in chemical respiratory sensitisation
There is a continuing interest in determining whether it is possible to identify thresholds for chemical allergy. Here allergic sensitisation of the respiratory tract by chemicals is considered in this context. This is an important occupational health problem, being associated with rhinitis and asthma, and in addition provides toxicologists and risk assessors with a number of challenges. In common with all forms of allergic disease chemical respiratory allergy develops in two phases. In the first (induction) phase exposure to a chemical allergen (by an appropriate route of exposure) causes immunological...
Allergie respiratoire professionnelle aux produits de la mer
L'exposition aéroportée aux poissons d'eau de mer, crustacés ou mollusques en milieu de travail peut entraîner une rhinite ou un asthme professionnels. Sont principalement concernés les professionnels du secteur de la pêche et de l'industrie agroalimentaire conditionnant, préparant et transformant ces denrées, mais aussi les ouvriers de l'aquaculture en mer et la conchyliculture, les employés du commerce alimentaire (poissonneries, grande distribution), les métiers de la restauration (cuisiniers, traiteurs...) voire...

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