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Dioxyde de titane sous forme nanoparticulaire : l’Anses définit une Valeur Toxicologique de Référence (VTR) pour l’exposition chronique par inhalation
Le dioxyde de titane sous forme nanoparticulaire est utilisé dans de nombreuses applications industrielles et commerciales. Dans le cadre de sa mission nationale d'élaboration de valeurs sanitaires de référence, l'Anses a été chargée de définir une Valeur Toxicologique de Référence (VTR) pour le dioxyde de titane sous forme nanoparticulaire (TiO 2 -NP). Suite à une analyse approfondie de l'ensemble des données de toxicité disponibles, l'Agence recommande une VTR chronique par inhalation pour...
New reports on alternatives assessment and substitution of harmful chemicals
A Cross Country Analysis of Approaches to Support Alternatives Assessment and Substitution of Chemicals of Concern that describes and gives a list of approaches developed across countries and by different stakeholders to support alternatives assessment and substitution of chemicals of concern. Source : http://www.oecd.org/fr/securitechimique/substitution-of-hazardous-chemicals.htm
Projet Amiante-Meta: bilan et perspectives
Quel bilan peut-on tirer du projet Amiante-Meta, lancé en 2012, pour accompagner les entreprises dans la mise en place d'actions de prévention des risques liés à l'amiante ? Cet article fait le point sur tous les aspects abordés dans ce projet (métrologie, mutualisation des données, vérification des facteurs de protection, nouveaux matériels) et dessine les perspectives d'actions à mettre en oeuvre pour poursuivre l'amélioration de la gestion du risque amiante. Source: http://www.inrs.fr/media.html?refINRS...
Are Operating Room Nurses at Higher Risk of Severe Persistent Asthma? The Nurses' Health Study
Objective : To assess the associations between operating room (OR) nursing, a category of health care workers at high risk of exposure to various inhaled agents, and asthma severity/control among women with asthma. Methods : The level of severity/control in nurses with prevalent doctor-diagnosed asthma in 1998/2000 was compared, using nominal logistic regression, in OR nursing (n = 69) and administrative nursing (n = 546) from the US Nurses' Health Study for whom detailed information on asthma and nursing employment status was available. Results : We observed a significant association between...
ChemView – A web-based tool
The U.S. Environmental Protection Agency (EPA) has launched a web-based tool, called ChemView, to significantly improve access to chemical specific regulatory information developed by EPA and data submitted under the Toxic Substances Control Act (TSCA). “This online tool will improve access to chemical health and safety information, increase public dialogue and awareness, and help viewers choose safer ingredients used in everyday products,” said James Jones, assistant administrator for the Office of Chemical Safety and Pollution Prevention. “The tool will make chemical information...
Guidance for manufactured nanomaterials from the Committee
The German Committee on Hazardous Substances (AGS) has issued Announcement 527 “Manufactured Nanomaterials”. The objective of the Announcement is to give recommendations for the protection of the safety and health of workers handling substances, mixtures, or articles consisting of, or containing, manufactured nanomaterials. The basis is the 2012 European Commission recommendation on the definition of the term ‘nanomaterial‘. Natural and incidental nanomaterials are not considered. Likewise, it does not address use by consumers. Though the announcement is indicative and complements...
Nanoparticules : Efficacité des filtres de protection respiratoire
Afin de minimiser l'exposition de travailleurs aux nanoparticules, une équipe de chercheurs a conçu une méthodologie permettant d'évaluer l'efficacité des appareils de protection respiratoire (APR) en reproduisant en laboratoire les conditions d'exposition à des particules de différentes tailles. À l'aide d'un banc d'essai expérimental, équipé d'un dispositif d'épuration d'air, les scientifiques ont analysé le rendement des filtres N95, soit ceux le plus couramment...
WHO Launches Chemical Risk Assessment Network
Chemicals play a vital part in our daily life. Chemicals can also cause unintended harm to human health. More than 25% of the global burden of disease is linked to environmental factors, including chemicals exposures. The production and use of chemicals continues to increase worldwide, particularly in rapidly developing economies. Enhanced global efforts are needed to share expertise, to assess, and to manage the risks associated with exposure to hazardous chemicals. There is a need to identify knowledge gaps and emerging issues, and to provide a forum for scientific exchange and collaboration...
Guidance document on developing and assessing adverse outcome pathways
The Adverse Outcome Pathway (AOP) methodology is an approach which provides a framework to collect, organise and evaluate relevant information on chemical, biological and toxicological effect of chemicals. This approach supports the use of a mode (and/or mechanism) of action basis for understanding adverse effects of chemicals. This guidance document intends to provide an insight into which pieces of information are necessary to identify and document an AOP and how to present them. It also provides initial assistance on how to undertake the assessment of an AOP in terms of its relevance and adequacy...
Evaluation of Systemic Health Effects Following Dermal Exposure to Chemicals - TR 119
Risk assessment of chemicals, including the REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) legislation, also cover assessments of dermal risk arising from exposure to chemicals. The European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) has produced this guidance consisting of a tiered approach for the risk assessment of dermal exposure to a chemical. The process developed by the Task Force consists of three linked decision trees, i.e.: Derivation of a health-based reference value; Initial risk characterisation; Refined risk characterisation. It is...
Occupational exposure to lead and lung cancer: results from two case-control studies in Montreal, Canada
Objectives We investigated the association between workplace lead exposure and lung cancer risk, separately for organic lead and for inorganic lead, from either engine emissions or from other sources. Methods Two population-based case-control studies were carried out in Montreal (1979–1986 and 1996–2002) to investigate occupational factors in relation to lung cancer among 1593 men with histologically confirmed incident lung cancer, and 1426 controls from the general population. Interviews elicited information on sociodemographic characteristics, lifetime smoking and occupational history...
Identification of Workers Exposed Concomitantly to Heat Stress and Chemicals
In the context of climate change, concomitant exposure to heat stress and chemicals takes on great importance. However, little information is available in this regard. The purpose of this research, therefore, was to develop an approach aimed at identifying worker groups that would be potentially most at risk. The approach comprises 5 consecutive steps: – Establishment of a list of occupations for all industry sectors – Determination of heat stress parameters – Identification of occupations at risk of heat stress – Determination of exposure to chemicals – Identification...
TR 116 : Category approaches, read-across, (Q)SAR
An accepted practice for the assessment of human health and environmental safety of chemicals is the use of models and analogues to fill data gaps for specific endpoints either for single or multiple chemicals that share structural similarities, and/or comparable reactivity or similarities in metabolism in mammals, fish and other organisms. For example, this approach is acceptable, with limitations, in preparing dossiers for REACH, and it supports efforts for reducing animal testing. The OECD has published guidance on the formation and use of chemical categories for data gap filling. An ECETOC...
Silver Nanoparticles: NIOSH Seeks Information and Comment
Federal Register carried a notice from the National Institute for Occupational Health and Safety (NIOSH) requesting information and comments regarding silver nanoparticles. NIOSH has initiated an evaluation of the scientific data on silver nanoparticles (AgNPs) to ascertain the potential health risks to workers and to identify gaps in knowledge so that appropriate laboratory and field research studies can be conducted. . . . Source : http://www.nanolawreport.com/2012/12/articles/silver-nanoparticles-niosh-seeks-information-and-comment/#axzz2FWeaNAg8 http://www.nanolawreport.com/uploads/file/77...
Shale gas extraction in the UK: A review of hydraulic fracturing
The health, safety and environmental risks associated with hydraulic fracturing (often termed 'fracking') as a means to extract shale gas can be managed effectively in the UK as long as operational best practices are implemented and enforced through regulation. Source : Source : http://www.raeng.org.uk/news/publications/list/reports/Shale_Gas.pdf
Banding the world together; the global growth of control banding and qualitative occupational risk management
Control Banding (CB) strategies to prevent work-related illness and injury for 2.5 billion workers without access to health and safety professionals has grown exponentially this last decade. CB originates from the pharmaceutical industry to control active pharmaceutical ingredients without a complete toxicological basis and therefore no occupational exposure limits. CB applications have broadened into chemicals in general - including new emerging risks like nanomaterials and recently into ergonomics and injury prevention. CB is an action-oriented qualitative risk assessment strategy offering solutions...
Chemical hazards in the organisation
The use of hazardous chemicals in organisations represents a substantial risk to occupational health, safety and the environment (OHSE). Organisational directors and managers have a responsibility to provide and maintain organisational management systems that manage these risks. The risk management approach of establishing organisational considerations, identifying chemical hazards (health and environmental), assessing and controlling risks and evaluating management activities has become the de facto means of managing organisational hazards in general and may be satisfactorily applied to the management...
Nanotech dangers outlined
It has been known for some time that inhaling tiny fibres made by the nanotechnology industry could cause similar health problems to asbestos. This is borne out by new research by the University of Edinburgh published in Toxicology Sciences. Research on mice, suggests the longer nanofibres are even more dangerous. Some of these fibres are similar in shape to asbestos fibres, which cause lung cancers such as mesothelioma. Nanofibres, which can be made from a range of materials including carbon, are about 1,000 times smaller than the width of a human hair and can reach the lung cavity when inhaled...
Workshop on Combined Exposure to Chemicals
In the last 10 years, there has been a significant amount of research into the toxicology of mixtures and co-exposure, which has genuinely increased our understanding. Participants at the workshop generally agreed that the WHO/IPCS framework provides a useful tool for risk assessment of combined exposure to multiple chemicals from multiple sources. A suitable problem formulation at the outset of any risk assessment of combined exposures to multiple chemicals was thought to be a fundamental first step. Source : http://www.ecetoc.org/index.php?mact=MCSoap,cntnt01,details,0&cntnt01by_category...
Travail et produits chimiques, liaisons dangereuses : DIRECCTE Pays-de-la-Loire
Sans viser à l’exhaustivité, cette publication passe en revue les problématiques les plus courantes concernant les agents chimiques dangereux et les CMR , par le biais de 121 questions-réponses, simples et directes, renvoyant le plus souvent à des situations de terrain ce qui en fait un document à la fois accessible et dynamique. Ce livret permet d’accéder aisément à toute une série d’informations pratiques, techniques et juridiques assortie de nombreux conseils et explications, citons à titre d’exemples...
EPA publishing IRIS review of Amphibole Asbestos
The US Environmental ProtectionAgency (EPA) published in the Federal Register, August 25, 2011, Draft Toxicological Review of Libby Amphibole Asbestos: In Support of the Summary Information on the Integrated Risk Information System. The deadline for comments is October 24, 2011. EPA is conducting a peer review of the scientific basis supporting the human health hazard of a specific type of asbestos resulting from the processing of vermiculite in Libby, Montana. Access the Federal Register notice: Source : http://www.gpo.gov/fdsys/pkg/FR-2011-08-25/pdf/2011-21722.pdf Access related EPA website for...
A new version of ECHA's chemical safety and report tool Chesar is now available-EU
Chesar is designed to help companies carry out their Chemical Safety Assessments (CSA) and preparing their Chemical Safety Reports (CSR). The tool developed by the European Chemicals Agency (ECHA) is a plug-in to IUCLID 5. Chesar version 1.2 can now be downloaded from the Chesar website. Chesar 1.2 enables the users to generate the exposure scenarios for communication to downstream users. These exposure scenarios can then be annexed to the extended Safety Data Sheet. Chesar also enables the registrant to create a full Chemical Safety Report (CSR), once the hazard assessment and (if required) the...
Control banding of chemicals exposure – Conference presentations now available - Europe
The EU-conference "Perspectives of Control Banding" took place in Dortmund on 21. / 22. June 2011 with more than 50 experts. Since December 2010 the extended provisions on safety data sheets (acc. to regulation no. 453/2010 from 20 may 2010) in the EU chemicals regulation REACH allows the use of control banding approaches to recommend risk management measures. This was the first European Workshop organised by the Federal Institute for Occupational Safety and Health (BAuA) in Germany with support by the ITG following six international (ICBW) and regional control banding workshops in Asia...
Véhicules industriels équipés au gaz naturel. Mesures de prévention contre le risque explosion
L'exploitation d'un parc de véhicules équipés au gaz naturel (GNV) est une activité dans laquelle le risque d'explosion est susceptible de se présenter du fait de la présence permanente d'un gaz combustible et de son stockage sous pression élevée de 20 MPa (200 bars). La mise en place des moyens de prévention et des mesures de protection est nécessaire et requiert une étude approfondie qui, outre la prise en compte du GNV sous pression élevée, se penchera sur la présence éventuelle...
Good control practice for workers' exposure to gases in landfill - Sampling and measurement report-RR870
Gases generated by decomposition of landfill contain, principally, methane and carbon dioxide, but may also contain hazardous concentrations of trace components. This project gathered information on the potential exposure of workers to these trace components during specific types of tasks, to provide evidence to develop guidance on good practice for the control of exposure. The study was conducted at six land fill sites identified as having the potential to generate high concentrations of three representative trace components, vinyl chloride, hydrogen sulphide and benzene. Comparisons of personal...
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