2018-02-01 12:00 - Messages

Associations Between Disinfection By-Product Exposures and Craniofacial Birth Defects

Objective: The aim of this study was to examine associations between craniofacial birth defects (CFDs) and disinfection by-product (DBP) exposures, including the sum of four trihalomethanes (THM4) and five haloacetic acids (HAA5) (ie, DBP9).
Methods: We calculated first trimester adjusted odds ratios (aORs) for different DBPs in a matched case–control study of 366 CFD cases in Massachusetts towns with complete 1999 to 2004 THM and HAA data.
Results: We detected elevated aORs for cleft palate with DBP9 (highest quintile aOR = 3.52; 95% CI: 1.07, 11.60), HAA5, trichloroacetic acid (TCAA), and dichloroacetic acid. We detected elevated aORs for eye defects with TCAA and chloroform.
Conclusion: This is the first epidemiological study of DBPs to examine eye and ear defects, as well as HAAs and CFDs. The associations for cleft palate and eye defects highlight the importance of examining specific defects and DBPs beyond THM4.

Source: Kaufman, J. A., Wright, J. M., Evans, A., Rivera-Núñez, Z., Meyer, A. et Narotsky, M. G. (2017). Journal of occupational and environmental medicine.

Occupational exposure to organic solvents and risk of male breast cancer

A European multicenter case-control study
Objectives: The etiology of male breast cancer (MBC) is largely unknown but a causal role of exposure to organic solvents has been suggested. Previous studies on occupational risk factors of breast cancer were often restricted to women who are frequently exposed to lower levels and at a lower frequency than men. We investigated the association between MBC and occupational exposure to petroleum and oxygenated and chlorinated solvents in a multicenter case–control study of rare cancers in Europe.
Methods: The study included 104 MBC cases and 1901 controls. Detailed lifetime work history was obtained during interviews, together with sociodemographic characteristics, medical history and lifestyle factors. Occupational exposures to solvents were estimated from a job-exposure matrix. Odds ratios (OR) and their 95% confidence intervals (CI) were calculated using unconditional logistic regression models.
Results: Lifetime cumulative exposure to trichloroethylene >23.9 ppm years was associated with an increased MBC risk, compared to non-exposure [OR (95% CI): 2.1 (1.2–4.0); P trend <0.01). This increase in risk persisted when only exposures that occurred ≥10 years before diagnosis were considered. In addition, a possible role for benzene and ethylene glycol in MBC risk was suggested, but no exposure–response trend was observed.
Conclusions: These findings add to the evidence of an increased risk of breast cancer among men professionally exposed to trichloroethylene and possibly to benzene or ethylene glycol. Further studies should be conducted in populations with high level of exposure to confirm our results.

Source: Laouali N, Pilorget C, Cyr D, Neri M, Kaerlev L, Sabroe S, Gorini G, Richiardi L, Morales-Suárez-Varela M, Llopis-Gonzalez A, Ahrens W, Jöckel K-H, Afonso N, Eriksson M, Merletti F, Olsen J, Lynge E, Guénel P. (2018). Scand J Work Environ Health.

Conditions reliées à l’exposition au béryllium au Québec : 1999-2011

Les dossiers médicaux de 123 travailleurs ayant soumis une réclamation à la Commission des normes, de l'équité, de la santé et de la sécurité du travail (CNESST) pour une condition reliée à l'exposition au béryllium entre le 1er janvier 1999 et le 31 décembre 2011 ont été analysés. Trois formes distinctes de conditions reliées au béryllium ont été étudiées, soit : la sensibilisation au béryllium, la bérylliose chronique asymptomatique et la bérylliose chronique.
Parallèlement à l'analyse des dossiers médicaux, les données concernant la profession et le secteur d'activité économique ont été extraites du Fichier des lésions professionnelles de la CNESST.

Source: https://www.inspq.qc.ca/publications/2337

Environmental and biological measurements of isoflurane and sevoflurane in operating room personnel

Purpose: The present study aimed to compare the concentration of isoflurane and sevoflurane in the individual's breathing zone and ambient air of operating rooms (ORs), to investigate the correlation between breathing zone levels and urinary concentrations, and to evaluate the ORs pollution in the different working hours and weeks.
Methods: Environmental and biological concentrations of isoflurane and sevoflurane were evaluated at 9ORs. Air samples were collected by active sampling method and urine samples were collected from each subject at the end of the work shift. All samples were analyzed using gas chromatography.
Results: The geometric mean ± GSD concentration of isoflurane and sevoflurane in breathing zone air were 1.41 ± 2.27 and 0.005 ± 1.74 ppm, respectively, while in post-shift urine were 2.42 ± 2.86 and 0.006 ± 3.83 µg/lurine, respectively. A significant positive correlation was found between the urinary and environmental concentration of isoflurane (r 2 = 0.724, P < 0.0001). The geometric mean ± GSD values of isoflurane and sevoflurane in ambient air were 2.30 ± 2.43 and 0.004 ± 1.56 ppm, respectively. The isoflurane concentration was different for three studied weeks and significantly increased over time in the ambient air of ORs.
Conclusions: The occupational exposure of OR personnel to isoflurane and sevoflurane was lower than national recommended exposure limits. The urinary isoflurane could be a good internal dose biomarker for monitoring of occupational isoflurane exposure. Considering the accumulation of anesthetic waste gases in the studied ORs, real-time air monitoring is better to be done at the end of the work shift.

Source: Jafari, A., Bargeshadi, R., Jafari, F., Mohebbi, I. et Hajaghazadeh, M. (2017). International archives of occupational and environmental health.

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