Measured Pulmonary and Systemic Markers of Inflammation and Oxidative Stress Following Wildland Firefighter Simulations

Objective: A controlled human exposure study was conducted to investigate the impact of inhalational exposures to wood smoke PM2.5 on measured concentrations of airway and systemic inflammatory biomarkers.
Methods: Mimicking wildland firefighter activities, 10 participants were exposed to three doses of wood smoke PM2.5 (filtered-air, 250?μg/m3, and 500?μg/m3) while exercising on a treadmill. Exhaled breath condensate (EBC) and blood plasma samples were obtained pre-, immediately post-, and 1-hour postexposure. 8-isoprostane, pH, and myeloperoxidase were measured in EBC, while H2O2, surfactant protein D, and pentraxin-3 (PTX3) were measured in both EBC and plasma.
Results: Only pH, 8-isoprostane, and PTX3 displayed significant changes when comparing pre- and postexposures.
Conclusions: Markers of inflammation and oxidative stress, including PTX3, pH, and 8-isoprostane in EBC and/or plasma, are sensitive to wood smoke inhalation, with further investigations warranted.

Source: Ferguson, Matthew D.; Semmens, Erin O.; Dumke, Charles; Quindry, John C.; Ward, Tony J. Journal of Occupational & Environmental Medicine: April 2016, Volume 58, Issue 4, p. 407-413.
http://dx.doi.org/10.1097/JOM.0000000000000688

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