Risk of Pancreatic Cancer in Female Textile Workers in Shanghai, China, Exposed to Metals, Solvents, Chemicals, and Endotoxin

Follow-Up to a Nested Case-Cohort Study
Objective: We studied associations between pancreatic cancer and occupational exposures to metals, solvents, chemicals, and endotoxin in a cohort of female textile workers in Shanghai, China. To assess the longer-term influences of these agents on pancreatic cancer we extended follow-up of this previously studied cohort.
Methods: We utilized a job exposure matrix to assess occupational exposures for 481 pancreatic cancer cases and a randomly selected sub-cohort of 3191 non-cases. We calculated hazard ratios and 95% confidence intervals using Cox proportional hazards modeling adapted for the case-cohort design.
Results: We observed a statistically significant trend of increasing hazard ratios associated with solvent exposure, but no associations with any of the remaining occupational exposures, including endotoxin and metals.
Conclusions: Our findings of increasing risk of pancreatic cancer with solvent exposures are consistent with published literature.

Source: Reul, Nicholas K.; Li, Wenjin; Gallagher, Lisa G.; Ray, Roberta M.; Romano, Megan E.; Gao, Daoli; Thomas, David B.; Vedal, Sverre; Checkoway, Harvey. Journal of Occupational & Environmental Medicine: February 2016, Volume 58, Issue 2, p. 195-199.

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