Evaluation of Systemic Health Effects Following Dermal Exposure to Chemicals - TR 119

Risk assessment of chemicals, including the REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) legislation, also cover assessments of dermal risk arising from exposure to chemicals. The European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) has produced this guidance consisting of a tiered approach for the risk assessment of dermal exposure to a chemical.

The process developed by the Task Force consists of three linked decision trees, i.e.:

  • Derivation of a health-based reference value;
  •  Initial risk characterisation; 
  • Refined risk characterisation.

It is designed to use existing exposure and toxicology data and identify data gaps or data inadequacies to be addressed to complete a risk assessment.  Each component of the decision trees is supported by explanation in the text and, in relevant cases, by an appendix providing additional detailed background information. This allows users with varying amounts of experience in risk assessment to access the guidance at different levels.

Source : http://www.ecetoc.org/index.php?mact=MCSoap,cntnt01,details,0&cntnt01by_category=22&cntnt01order_by=date%20Desc&cntnt01template=display_list_v2&cntnt01display_template=display_details_v2&cntnt01document_id=7081&cntnt01returnid=59

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