Effects of Chemical Co-exposures at Doses Relevant for Human Safety Assessments

Chemical regulation is mainly based on single substances, but exposure is to complex mixtures, which raises the question of whether the regulatory framework is adequate and protective. There has long been an interest in the toxicology of mixtures, but most studies have been conducted at effect levels for the components of a mixture. This review focused specifically on studies where a mixture has been tested at doses which are at or below the NO(A)EL for every component of the mixture. This is the only dose region in which mixture toxicity could threaten regulatory safety margins. A thorough literature review was conducted using this selection criterion and others, for example only studies using models of mammalian systems were considered. Most studies that were examined failed to meet the selection criteria, but a total of 91 relevant papers were identified. An additional literature review identified 52 papers in which studies of real or artificial mixtures representing environmental exposures were reported, e.g. tap water.

Source : http://www.ecetoc.org/index.php?mact=MCSoap,cntnt01,details,0&cntnt01by_category=22&cntnt01order_by=date%20Desc&cntnt01template=display_list_v2&cntnt01display_template=display_details_v2&cntnt01document_id=6370&cntnt01returnid=59

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