Occupational exposure to particles and incidence of stroke

Objectives This paper aims to investigate the relation between occupational exposure to particles, particle size, and the incidence of ischemic and hemorrhagic stroke.
Methods The cohort included all manual workers identified from the Swedish National Census in 1980, who were alive as of 1 January 1987. First time events of ischemic or hemorrhagic stroke during the period 1987–2005 were identified through linkage to the Hospital Discharge Register and the National Cause of Death Register. A job-exposure matrix for exposure to small (1 µm) particles was developed and applied. Hazard ratios (HR) were estimated by Cox regression with adjustment for age, socioeconomic group, and residential area.
Results Increased HR of ischemic as well as hemorrhagic stroke were found among both women and men occupationally exposed to small as well as large particles. The risks were higher for workers exposed for ≥5 years compared to “ever exposed” participants indicating a dose–response relationship, but no trend with exposure intensity was observed. The risks were generally higher for women than men. <> Conclusions Occupational exposure to small and large particles was associated with increased risks of ischemic and hemorrhagic stroke. Further studies are needed to explore the relationships between exposure to different types of particles and various doses and the occurrence of stroke among women as well as men.

Source : http://www.sjweh.fi/show_abstract.php?abstract_id=3271

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