Transcriptional Pathways Altered in Response to Vibration in a Model of Hand-Arm Vibration Syndrome

Objective: The aim of this study was to use an established model of vibration-induced injury to assess frequency-dependent changes in transcript expression in skin, artery, and nerve tissues.
Methods: Transcript expression in tissues from control and vibration-exposed rats (4h/day for 10 days at 62.5, 125, or 250?Hz; 49m/s2, rms) was measured. Transcripts affected by vibration were used in bioinformatics analyses to identify molecular- and disease-related pathways associated with exposure to vibration.
Results: Analyses revealed that cancer-related pathways showed frequency-dependent changes in activation or inhibition. Most notably, the breast-related cancer-1 pathway was affected. Other pathways associated with breast cancer type 1 susceptibility protein related signaling, or associated with cancer and cell cycle/cell survivability were also affected.
Conclusion: Occupational exposure to vibration may result in DNA damage and alterations in cell signaling pathways that have significant effects on cellular division.

Source: Waugh, Stacey; Kashon, Michael L.; Li, Shengqiao; Miller, Gerome R.; Johnson, Claud; Krajnak, Kristine. Journal of Occupational & Environmental Medicine: April 2016, Volume 58, Issue 4, p. 344-350.
http://dx.doi.org/10.1097/JOM.0000000000000705

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